Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'

In 2008, this group published a paper on approaches for two‐stage crossover bioequivalence (BE) studies that allowed for the reestimation of the second‐stage sample size based on the variance estimated from the first‐stage results. The sequential methods considered used an assumed GMR of 0.95 as part of the method for determining power and sample size. This note adds results for an assumed GMR = 0.90. Two of the methods recommended for GMR = 0.95 in the earlier paper have some unacceptable increases in Type I error rate when the GMR is changed to 0.90. If a sponsor wants to assume 0.90 for the GMR, Method D is recommended. Copyright © 2011 John Wiley & Sons, Ltd.     

Using Daydreams in Psychodynamic Psychotherapy

Daydreams, long recognized as containers of unarticulated, unrecognized and/or unconscious material, can be subtle but powerful tools for introducing clients to the process of exploring internal experience. They offer a crucial, relatively non-threatening path to self-understanding for individuals who come into therapy without the capacity for introspection, tolerance of affect, and sense of agency that are requisite for the process of psychodynamic psychotherapy. In part because they are often available to conscious awareness, they are an amazingly useful medium through which to help many of these clients gain access to their internal world. They encourage the development of the capacity to symbolize, to play, and eventually to embrace the potential space of internal experience that makes it possible to have a rich and fulfilling life in the external world. In this article, the author introduces the use of daydreams in psychodynamic psychotherapy, focusing specifically on three specific areas: resistance, somatization, and transference.     

Work value orientations and patterns: A comparison of future managers with manager and non-manager groups

This study uses the Values for Working questionnaire to classify the primary value systems and value patterns of 501 senior business school students (future managers). The students' scores on six value systems measured by the questionnaire are compared to national data on blue collar and clerical workers and on managerial and professional workers. The business students scored in the average range for four of the six value systems when compared to the manager group, but for only one of the value systems when compared to the non-manager group. Of the business students who had a primary value system, 82 percent wereexistential ormanipulative. There were significant differences in the value systems scores by sex but not by business major.     

Infants' Sensitivity to Manipulations of Maternal Touch During Face-to-Face Interactions*

Forty-eight mothers and their 5.5-month-olds participated in a series of face-to-face interactions consisting of a Normal plus three still-face (SF) periods where mothers could touch their infants (SF with touch). The primary objective was to determine whether young infants are sensitive to subtle changes in maternal touch. Variations in infants' affective and attentional responses were revealed as a function of the different periods; infants smiled more when mothers were requested to maximize their smiling using touch alone, and gaze shifted from mothers' faces in the Normal period to their hands in the SF with touch periods. Results imply that: (1) infants are sensitive to subtle changes in their mothers' touching, (2) mothers are effective in using touch to elicit specific infant responses, (3) touch-only interactions are positive, as reflected in infants' gaze and affective displays, (4) mothers use consistent types of touch when touching specific areas of their infants' bodies during brief interactions.     

Household Composition and Poverty among Female‐Headed Households with Children: Differences by Race and Residence*

Abstract We examine race and residential variation in the prevalence of female‐headed households with children and how household composition is associated with several key economic well‐being outcomes using data from the 2000 5% Public Use Microdata Sample of the U.S. Census. Special attention is paid to cohabiting female‐headed households with children and those that are headed by a single grandmother caring for at least one grandchild, because these are becoming more common living arrangements among female‐headed households with children. We find that in 2000: (1) cohabiting and grandmother female‐headed households with children comprised over one‐fourth of all female‐headed households with children, (2) household poverty is highest for female‐headed households with children that do not have other adult household earners, (3) earned income from other household members lifts many cohabiting and grandparental female‐headed households out of poverty, as does retirement and Social Security income for grandmother headed households, and (4) poverty is highest among racial/ethnic minorities and for female‐headed households with children in nonmetro compared to central cities and suburban areas.     

Legitimacy and the Role of UK Third Sector Organizations in the Policy Process

This paper explores the legitimacy of third sector organizations in the policy process in the United Kingdom. It draws on empirical research to examine how legitimacy is defined, both by third sector organizations and by those they target within government. The paper argues that while many third sector organizations give high priority to political forms of legitimacy—in the sense of participatory structures and accountability to members and beneficiaries—government is generally more likely to give priority to technical forms of legitimacy, e.g., the quality of research and the ability to implement policy. Nonetheless, political legitimacy is still important, first because this is the form of legitimacy that third sector organizations claim for themselves and second because, as government gives way to governance with an increase in partnerships and collaboration, the dilemmas faced by third sector organizations in achieving political legitimacy are being faced on a broader canvas.     

Optimal adaptive sequential designs for crossover bioequivalence studies

In prior works, this group demonstrated the feasibility of valid adaptive sequential designs for crossover bioequivalence studies. In this paper, we extend the prior work to optimize adaptive sequential designs over a range of geometric mean test/reference ratios (GMRs) of 70–143% within each of two ranges of intra‐subject coefficient of variation (10–30% and 30–55%). These designs also introduce a futility decision for stopping the study after the first stage if there is sufficiently low likelihood of meeting bioequivalence criteria if the second stage were completed, as well as an upper limit on total study size. The optimized designs exhibited substantially improved performance characteristics over our previous adaptive sequential designs. Even though the optimized designs avoided undue inflation of type I error and maintained power at 80%, their average sample sizes were similar to or less than those of conventional single stage designs. Copyright © 2015 John Wiley & Sons, Ltd.     

The Relationship Between Maternal Education and Children's Academic Outcomes: A Theoretical Framework

The importance of maternal education for children's academic outcomes is widely recognized, and yet the multiple potential mechanisms that explain this relationship are underexplored. The authors integrate theories of human, cultural, and social capital with 2 developmental psychology theories—bioecological theory and developmental niche theory—to draw attention to how maternal education may influence children's academic outcomes through a range of parenting mechanisms, some of which have been largely neglected in research. This framework provides a more complete picture of how maternal education shapes proximal and distal influences on children's academic outcomes and the ways in which these mechanisms interact and reinforce one another across time and context. The implications of this framework for future family research are then discussed.     

Using collaboration to maximize outcomes for a John A. Hartford Foundation geriatric enrichment project

Two institutions representing two BSW and one MSW program and a geriatric education center collaborated in a John A. Hartford geriatric enrichment project. Sharing the risks and benefits of a collaborative model, 75 percent of faculty participated in mini faculty fellowships, and bi-monthly dinner meetings with colleagues from each of the three programs, and actively engaged in the curricula revisions. Faculty report pervasive geriatric enrichment in each program's foundation content areas, and increases in students placed in geriatric enriched field practicum settings, from pre-project levels of 8.1 percent to a high of 24 percent. The features of the collaborative project include: respecting each program's autonomy while actively sharing ideas, resources and partnering with community's aging experts; and strengthening mutually reciprocal relationships among faculty and the gerontologic practice community. This model of shared risks and benefits also provides opportunities for innovation, diverse thinking, and shared decision making.