Modelling and simulation to improve decision‐making in clinical development

Modelling and simulation are buzz words in clinical drug development. But is clinical trial simulation (CTS) really a revolutionary technique? There is not much more to CTS than applying standard methods of modelling, statistics and decision theory. However, doing this in a systematic way can mean a significant improvement in pharmaceutical research. This paper describes in simple examples how modelling could be used in clinical development. Four steps are identified: gathering relevant information about a drug and the disease; building a mathematical model; predicting the results of potential future trials; and optimizing clinical trials and the entire clinical programme. We discuss these steps and give a number of examples of model components, demonstrating that relatively unsophisticated models may also prove useful. We stress that modelling and simulation are decision tools and point out the benefits of integrating them with decision analysis. Copyright © 2005 John Wiley & Sons, Ltd.     

A review of outsourcing from the resource‐based view of the firm

The phenomenon of outsourcing is becoming increasingly widespread among organizations and is now one of the strategic decisions that attract the greatest interest from professionals and organizational scholars. The primary purpose of the paper is to contribute with a review of the principal works that address outsourcing from the resource‐based view of the firm (RBV). The paper begins by setting out the main premises of outsourcing and then presents the different concepts of outsourcing and proposes a concept that is more in line with the theoretical framework used. This is followed by an analysis of the principal differences and similarities of the treatments of outsourcing from the traditional perspective of the transaction costs economics theory (TCE) and from the more strategic and up‐to‐date RBV. The next section contains a review of the most significant theoretical and empirical works on outsourcing that address outsourcing from the RBV. The contributions are classified into two categories, depending on the objectives: works that study the propensity to outsource and works that study the relationship between the outsourcing decision and organizational performance. Finally, a framework is proposed that is based on the resource and capability view with the aim of contributing to a better understanding of outsourcing and facilitating future empirical works from the RBV that are complementary and examine issues of greater interest that have been less developed in the literature to date.     

Untersuchung der autoritären Einstellung bei ungarischen StudentInnen

We asked daytime university and college students to complete the survey, which aimed at examining the authoritarian attitude of those questioned, and the factors in connection to it. The questionnaire was made up of 23 statements, and those questioned had to express how far they agree on a five grade scale (N = 349). On the basis of the answers it could be stated that the different groups of those planning to work in different fields differ from each other also from the point of view of accepting authority: from those groups which were examined in greater numbers the physical education teachers and the theologians were the most authoritarian, while the social workers and students of human studies were the least. Those answering differed also in terms of religiousness: those considering themselves religious and close to the church seemed to be the most authoritarian and those who are not religious the least. The results were interestingly coloured by the fact that in assessing specific social situations the social workers and the convinced non-religious ones showed signs of more authoritarian attitude. Results also proved that the own opinion about authoritarianism is related to the opinion of the parents. Beside many other questions we also examined whether authoritarianism is related to the situation when someone is stricter to him/herself and to those emotionally closer than to others.     

Selfishness of the affluent? stateless nationalist and regionalist parties and immigration

ABSTRACT

This paper examines stateless nationalist and regionalist party (SNRP) discourses on immigration through an exploration of the economic dimensions of the centre-periphery cleavage. Using qualitative document analysis, the Republican Left in Catalonia (ERC) and the Scottish National Party (SNP) in Scotland are studied in order to see whether and how the relative economic position of a region shapes SNRP discourses on immigration. The period of analysis encompasses the last three terms of office for both parties, during which immigration and decentralisation have been very salient issues in Catalonia and Scotland. Results suggest that the relative economic situations and the economic crisis do not seem to affect general stances, which are positive in both regions. However, the economic contexts have an influence on how each party selects its main issues for debate, and the ways in which these are managed.     

Improving Social Work Education in Vietnam Through International Cooperation: The ‘Social Work Education Enhancement Program’

This paper describes an initiative to improve social work education in Vietnam through a three-year international collaborative, including US Aid for International Development, San José State University, eight universities in Vietnam, Vietnam's government ministries, and Cisco Systems, Inc. The social work profession was officially recognized by the Vietnamese government in 2010. Despite the rapid expansion of social work education programs, there are significant limitations in the universities' ability to provide social work education. The goal of the Social Work Education Enhancement Program (SWEEP) is to strengthen the capacity of Vietnam's undergraduate social work programs to deliver quality education and prepare trained, job-ready social workers. The SWEEP project aims to improve the administration of social work education, the professional capacity of faculty, social work curriculum, and networking technology to enable centers for excellence in learning and scholarship. To ensure that the SWEEP team targeted training and technical assistance activities that were culturally congruent, a comprehensive needs assessment and frequent mid-course evaluations were conducted, showing many shared and unique contextual issues facing universities. The collaborative process of developing social work education which fits the local context can be replicated in other countries that are in the early stages of social work development.     

Employee and Volunteer

The purpose of this research is to analyze the different factors that determine the level of time devoted to volunteer activity involving employed people. To this end, we applied a logistic regression model to a sample of 5,067 employees, considering four categories of factors: family and personal, on the one hand, and contextual factors, on the other. This second group involves three factor categories: occupational, organizational, and community involvement factors. The findings of this work are especially relevant to two areas: first, to design a policy of corporate social responsibility that effectively integrates the figure of corporate volunteering, considering its pertinent factors; and second, to broaden the perspective of the third‐sector organizations beyond the traditional profile with which volunteers are commonly associated.     

Identifying students’ intercultural communicative competence at the beginning of their placement: towards the enhancement of study abroad programmes

A pre-placement questionnaire was completed by a cohort of 30 students participating in the Erasmus exchange programmes from the University of Salamanca, placed in British universities, and by a group of 25 Nottingham Trent University students hosted by diverse Spanish universities. The questionnaire was then analysed with the aim of providing a profile of their intercultural communicative competence (ICC), based on data about their self-perceived motivation and their intercultural awareness, knowledge, attitudes and skills, prior to their stay abroad. Despite the fact that their previous experience abroad, level of language proficiency and home university requirements for the placement differed, both groups shared a positive attitude towards the host country, considered themselves ready to adapt to new cultural environments, regarded misperceptions and solving conflicts as their greater challenge and expressed a willingness to grow personally and professionally. These data will inform a larger research project seeking to identify the factors that promote the acquisition of intercultural competences, as a basis for universities to equip students with tools aimed at overcoming obstacles that may pose an educational challenge for them and hinder the development of their ICC while on placement abroad.     

Analyzing and clustering students' application preferences in higher education

We present a framework based on a higher education application preference list that allows a different type of flexible aggregation and, hence, the analysis and clustering of application data. Preference lists are converted into scores. The proposed approach is demonstrated in the context of higher education applications in Hungary over the period of 2006–2015. Our method reveals that efforts to leverage center-periphery differences do not fulfill expectations. Furthermore, the student''s top preference is very hard to influence, and recruiters may build their strategy on information about the first and second choices.     

Residualization: justification,properties and application

Although it is usual to find collinearity in econometric models, it is commonly disregarded. An extended solution is to eliminate the variable causing the problem but, in some cases, this decision can affect the goal of the research. Alternatively, residualization not only allows mitigation of collinearity, but it also provides an alternative interpretation of the coefficients isolating the effect of the residualized variable. This paper fully develops the residualization procedure and justifies its application not only for dealing with multicollinearity but also for separating the individual effects of the regressor variables. This contribution is illustrated by two econometric models with financial and ecological data, although it can also be extended to many different fields.