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51.
A Bayesian approach, implemented using Markov Chain Monte Carlo (MCMC) analysis, was applied with a physiologically‐based pharmacokinetic (PBPK) model of methylmercury (MeHg) to evaluate the variability of MeHg exposure in women of childbearing age in the U.S. population. The analysis made use of the newly available National Health and Nutrition Survey (NHANES) blood and hair mercury concentration data for women of age 16–49 years (sample size, 1,582). Bayesian analysis was performed to estimate the population variability in MeHg exposure (daily ingestion rate) implied by the variation in blood and hair concentrations of mercury in the NHANES database. The measured variability in the NHANES blood and hair data represents the result of a process that includes interindividual variation in exposure to MeHg and interindividual variation in the pharmacokinetics (distribution, clearance) of MeHg. The PBPK model includes a number of pharmacokinetic parameters (e.g., tissue volumes, partition coefficients, rate constants for metabolism and elimination) that can vary from individual to individual within the subpopulation of interest. Using MCMC analysis, it was possible to combine prior distributions of the PBPK model parameters with the NHANES blood and hair data, as well as with kinetic data from controlled human exposures to MeHg, to derive posterior distributions that refine the estimates of both the population exposure distribution and the pharmacokinetic parameters. In general, based on the populations surveyed by NHANES, the results of the MCMC analysis indicate that a small fraction, less than 1%, of the U.S. population of women of childbearing age may have mercury exposures greater than the EPA RfD for MeHg of 0.1 μg/kgg/day, and that there are few, if any, exposures greater than the ATSDR MRL of 0.3 μgg/kgg/day. The analysis also indicates that typical exposures may be greater than previously estimated from food consumption surveys, but that the variability in exposure within the population of U.S. women of childbearing age may be less than previously assumed. 相似文献
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Yazan A. Al-Ajlouni Su Hyun Park Eric W. Schrimshaw William C. Goedel 《Journal of gay & lesbian social services》2019,31(3):358-369
It has been demonstrated that sexual minority men (SMM) participate in sexting. While research has shown that engagement in the exchange of sexually explicit media is associated with poor health outcomes, no previous research has investigated its association with sleep health outcomes. This study sought to examine the association between sexually explicit media and sleep health among SMM, a population that suffers from poor sleep health. A popular geosocial networking application was used to recruit SMM individuals (N?=?580) in the Paris, France, metropolitan area. Multivariate analyses, adjusting for sociodemographics, were used to test the association between the frequency of sexually explicit messaging and three dimensions of sleep health: (1) sleep quality, (2) sleep duration, and (3) two aspects of sleep problems. In multivariate analyses, those who reported engaging in sexually explicit messaging more were more likely to report getting less than seven?hours of sleep (aRR = 1.24; 95% CI = 1.08, 1.43) compared with those who reported engaging in sexually explicit messaging less. No significant associations were found between sexting and sleep quality or reporting sleep problems. Sexually explicit messaging was associated with shorter sleep duration. Intervention targeted at individuals who sext could potentially improve sleep health outcomes. 相似文献
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As a masculinist space, ‘the streets’ present a variety of dangers to homeless women, a fact that has received too little attention within the social science literature. This study utilizes data drawn from interviews with homeless women and service providers in Edinburgh, San Francisco, Vancouver, Montreal and Ottawa, to explore the complex survival strategies that homeless women develop to prevent criminal victimization. Through women's words, we see that gender is understood strategically as performance. Four gender performances are identified and discussed: the ‘femininity simulacrum’, the ‘masculinity simulacrum’, ‘genderlessness’ and ‘passing’. We discussed how each of these performances is employed in the pursuit of safety and security in frequently violent and chaotic social spaces. 相似文献
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Les systèmes nationaux et internationaux de régulation du travail, loin de s'opposer, sont largement imbriqués. De hautes juridictions nationales ont utilisé les normes de l'OIT dans de récentes décisions. Les auteurs décryptent les conditions et les conséquences de cet usage en examinant deux décisions de la Cour suprême du Canada (liberté syndicale) et une de la Cour d'appel de Paris (contrat de travail). Outre que ces affaires ont fait l'objet de procédures tant nationales qu'internationales, le choix de pays aux cultures juridiques différentes permet de discuter l'appropriation du droit international du travail par les juridictions nationales. 相似文献
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John Eric Baugher 《Symbolic Interaction》2008,31(3):259-284
This article draws on ethnographic data to examine how moral person‐hood, emotions, and social relationships are constructed quite differently within two organizations with the similar goal of holistically caring for the dying. The analysis shows how the moral rhetoric and related practices at a mainstream hospice encourage volunteers to esteem a static conception of the self‐as‐character, whereas the Buddhist approach requires volunteers to engage in a process of transcending a self that is continually being worked on. The analysis points to paradoxes in the hospice conceptions of a “good death” and offers critical reflection on the assumption that Western and Buddhist approaches to hospice care are largely equivalent. Organizational, structural, and phenomenological strands of symbolic interactionist thought are drawn on to interpret these findings. 相似文献