Type I and Type II error rates in the last observation carried forward method under informative dropout

Dropout is a persistent problem for a longitudinal study. We exhibit the shortcomings of the last observation carried forward method. It produces biased estimates of change in an outcome from baseline to study endpoint under informative dropout. We developed a theoretical quantification of the effect of such bias on type I and type II error rates. We present results for a setup where a subject either completes the study or drops out during one particular interval, and also under the setup in which subjects could drop out at any time during the study. The type I error rate steadily increases when time to dropout decreases or the common sample size increases. The inflation in type I error rate can be substantially high when reasons for dropout in the two groups differ; when there is a large difference in dropout rates between the control and treatment groups and when the common sample size is large; even when dropout subjects have one or two fewer observations than the completers. Similar results are also observed for type II error rates. A study can have very low power when early recovered patients in the treatment group and worsening patients in the control group drop out even near the end of the study.     

Identifying Factors Influencing Perceived Quality of Life (QoL) of Indian Elderly: Case Study of Kolkata,India

Social Indicators Research - Well-being of the Indian elderly is presently a concern in the urban Indian society due to the gradual decline in the capacity of the family to serve as care-givers for...     

BALANCED ARRAYS AND WEIGHING DESIGNS

Dey (19711, Saha (1975), Kageyama & Saha (1983) and others have shown how optimum chemical balance weighing designs can be constructed from the incidence matrices of balanced incomplete block (BIB) designs. In this paper, it is shown that weighing designs can be constructed from some suitably chosen two-symbol balanced arrays of strength two, which need not always be incidence matrices of BIB designs. The findings lead us to construct new optimum chemical balance weighing designs from incidence matrices of BIB designs.     

A modified unrelated question randomized response device for complex surveys

Singh et al. (Stat Trans 6(4):515–522, 2003) proposed a modified unrelated question procedure and they also demonstrated that the modified procedure is capable of producing a more efficient estimator of the population parameter π _A , namely, the proportion of persons in a community bearing a sensitive character A when π _A  < 0.50. The development of Singh et al. (Stat Trans 6(4):515–522, 2003) is based on simple random samples with replacement and on the assumption that π _B , namely, the proportion of individuals bearing an unrelated innocuous character B is known. Due to these limitations, Singh et al.’s (Stat Trans 6(4):515–522, 2003) procedure cannot be used in practical surveys where usually the sample units are chosen with varying selection probabilities. In this article, following Singh et al. (Stat Trans 6(4):515–522, 2003) we propose an alternative RR procedure assuming that the population units are sampled with unequal selection probabilities and that the value of π _B is unknown. A numerical example comparing the performance of the proposed RR procedure under alternative sampling designs is also reported.     

A trajectory analysis of body mass index for Finnish children

The aim of this study is to investigate the early development of body mass index (BMI), a standard tool for assessing the body shape and average level of adiposity for children and adults. The main aim of the study is to identify the primary trajectories of BMI development and to investigate the changes of certain growth characteristics over time. Based on our longitudinal data of 4223 Finnish children, we took anthropometric measurements from birth up to 15 years of age for birth years 1974, 1981, 1991 and 1995, but only up to 11 years of age for the birth year 2001. As a statistical method, we utilized trajectory analysis with the methods of nonparametric regression. We identified four main trajectories of BMI growth. Two of these trajectories do not seem to follow the normal growth pattern. The highest growth track appears to yield to a track that may yield to overweight and the low birth BMI track shows that the girls’ track differs that of boys on the same track, and on the normal tracks. The so-called adiposity rebound time decreased over time and started earlier for those on the overweight track. According to our study, this kind of acceleration of growth might be more of a general phenomenon that also relates to the other phases of BMI development. The major change seems to occur especially for those children on high growth tracks.     

Profile likelihood-based confidence interval for the dispersion parameter in count data

The importance of the dispersion parameter in counts occurring in toxicology, biology, clinical medicine, epidemiology, and other similar studies is well known. A couple of procedures for the construction of confidence intervals (CIs) of the dispersion parameter have been investigated, but little attention has been paid to the accuracy of its CIs. In this paper, we introduce the profile likelihood (PL) approach and the hybrid profile variance (HPV) approach for constructing the CIs of the dispersion parameter for counts based on the negative binomial model. The non-parametric bootstrap (NPB) approach based on the maximum likelihood (ML) estimates of the dispersion parameter is also considered. We then compare our proposed approaches with an asymptotic approach based on the ML and the restricted ML (REML) estimates of the dispersion parameter as well as the parametric bootstrap (PB) approach based on the ML estimates of the dispersion parameter. As assessed by Monte Carlo simulations, the PL approach has the best small-sample performance, followed by the REML, HPV, NPB, and PB approaches. Three examples to biological count data are presented.     

AIDS KNOWLEDGE AND ATTITUDES AMONG CANBERRA SECONDARY SCHOOL STUDENTS

This paper reports findings from a study of 1,014 Canberra secondary school students in 15 government and private schools. Open-ended responses concerning students' understanding of AIDS, and their views regarding prevention, are presented and discussed. Data on source of AIDS information are also investigated. In general, students understand AIDS as sex-linked, that it involves transmission through the blood, and that there is no cure for it. They espouse more research and education as the main preventive measures, although males also propose homophobic solutions. Teachers and television are the primary sources of AIDS information. Differences by sex of respondent and school type are reported and implications for school-based AIDS education policies are suggested.     

Analysis of one-way layout of count data in the presence of over or under dispersion

This article develops test statistics for the homogeneity of the means of several treatment groups of count data in the presence of over-dispersion or under-dispersion when there is no likelihood available. The C(α)$C(\alpha )$ or score type tests based on the models that are specified by only the first two moments of the counts are obtained using quasi-likelihood, extended quasi-likelihood, and double extended quasi-likelihood. Monte Carlo simulations are then used to study the comparative behavior of these C(α)$C(\alpha )$ statistics compared to the C(α)$C(\alpha )$ statistic based on a parametric model, namely, the negative binomial model, in terms of the following: size; power; robustness for departures from the data distribution as well as dispersion homogeneity. These simulations demonstrate that the C(α)$C(\alpha )$ statistic based on the double extended quasi-likelihood holds the nominal size at the 5% level well in all data situations, and it shows some edge in power over the other statistics, and, in particular, it performs much better than the commonly used statistic based on the quasi-likelihood. This C(α)$C(\alpha )$ statistic also shows robustness for moderate heterogeneity due to dispersion. Finally, applications to ecological, toxicological and biological data are given.     

Analysis of proportions for clustered binary data in the presence of unequal dispersions

This paper investigates the test procedures for testing the homogeneity of the proportions in the analysis of clustered binary data in the context of unequal dispersions across the treatment groups. We introduce a simple test procedure based on adjusted proportions using a sandwich estimator of the variance of the proportion estimators obtained by the generalized estimating equations approach of Zeger and Liang (1986) [Biometrics 42, 121-130]. We also extend the exiting test procedures of testing the hypothesis of proportions in this context. These test procedures are then compared, by simulations, in terms of size and power. Moreover, we derive the score test for testing the homogeneity of the dispersion parameters among several groups of clustered binary data. An illustrative application of the recommended test procedures is also presented.