Negative variance components for non-negative hierarchical data with correlation,over-, and/or underdispersion

The concept of negative variance components in linear mixed-effects models, while confusing at first sight, has received considerable attention in the literature, for well over half a century, following the early work of Chernoff [7 H. Chernoff, On the distribution of the likelihood ratio, Ann. Math. Statist. 25 (1954), pp. 573–578.[Crossref] , [Google Scholar]] and Nelder [21 J.A. Nelder, The interpretation of negative components of variance, Biometrika 41 (1954), pp. 544–548.[Crossref], [Web of Science ®] , [Google Scholar]]. Broadly, negative variance components in linear mixed models are allowable if inferences are restricted to the implied marginal model. When a hierarchical view-point is adopted, in the sense that outcomes are specified conditionally upon random effects, the variance–covariance matrix of the random effects must be positive-definite (positive-semi-definite is also possible, but raises issues of degenerate distributions). Many contemporary software packages allow for this distinction. Less work has been done for generalized linear mixed models. Here, we study such models, with extension to allow for overdispersion, for non-negative outcomes (counts). Using a study of trichomes counts on tomato plants, it is illustrated how such negative variance components play a natural role in modeling both the correlation between repeated measures on the same experimental unit and over- or underdispersion.     

Multiple imputation for ordinal longitudinal data with monotone missing data patterns

Missing data often complicate the analysis of scientific data. Multiple imputation is a general purpose technique for analysis of datasets with missing values. The approach is applicable to a variety of missing data patterns but often complicated by some restrictions like the type of variables to be imputed and the mechanism underlying the missing data. In this paper, the authors compare the performance of two multiple imputation methods, namely fully conditional specification and multivariate normal imputation in the presence of ordinal outcomes with monotone missing data patterns. Through a simulation study and an empirical example, the authors show that the two methods are indeed comparable meaning any of the two may be used when faced with scenarios, at least, as the ones presented here.     

A shared parameter model of longitudinal measurements and survival time with heterogeneous random-effects distribution

Typical joint modeling of longitudinal measurements and time to event data assumes that two models share a common set of random effects with a normal distribution assumption. But, sometimes the underlying population that the sample is extracted from is a heterogeneous population and detecting homogeneous subsamples of it is an important scientific question. In this paper, a finite mixture of normal distributions for the shared random effects is proposed for considering the heterogeneity in the population. For detecting whether the unobserved heterogeneity exits or not, we use a simple graphical exploratory diagnostic tool proposed by Verbeke and Molenberghs [34] to assess whether the traditional normality assumption for the random effects in the mixed model is adequate. In the joint modeling setting, in the case of evidence against normality (homogeneity), a finite mixture of normals is used for the shared random-effects distribution. A Bayesian MCMC procedure is developed for parameter estimation and inference. The methodology is illustrated using some simulation studies. Also, the proposed approach is used for analyzing a real HIV data set, using the heterogeneous joint model for this data set, the individuals are classified into two groups: a group with high risk and a group with moderate risk.     

A comparative study on estimation methods to deal with the endogeneity in linear random-intercept models with an extension

In this paper, we investigate estimation methods to deal with situations where random intercepts are associated to time-varying covariates in the context of linear mixed models. First, a review of previous ways to deal with this so-called endogeneity issue is presented, then a new method based on shared random effects is proposed. Simulation studies and an empirical example are utilized to assess the performance of our proposed method. It is shown that our new approach is more efficient than most competitors and is robust to the misspecification of the random-effects distributions.     

Quality of Life Measurement in the Field of Intellectual Disabilities: Eight Principles for Assessing Quality of Life-Related Personal Outcomes

As the concept of quality of life (QOL) has evolved from a theoretical concept to both a measurable construct and an action-oriented change agent in the field of intellectual disabilities, there has emerged a corresponding need to develop, implement, and use a systematic approach to the assessment of domain-referenced quality of life outcomes. The purpose of this article is to suggest eight principles based on published literature and the authors’ experiences that should underlie the assessment of QOL-related personal outcomes in the field of intellectual disabilities. Data from the development of the personal outcomes scale are used to exemplify each principle. The article’s premise is that model development and test construction should work in tandem, and that a ‘quality of life assessment instrument’ should be based on an empirically derived QOL conceptual and measurement framework/model.     

One size fits all? The social construction of dis-employ-abled women

This article is based on an evaluation of a labour-market training programme for women with ‘mental health problems’ in a social workplace in Belgium. The research team explored the retrospective insider perspectives on the work aspirations of the women involved in the programme to identify critical dynamics in their high drop-out from the social workplace. The central findings provide evidence of a prevalent one-size-fits-all discourse in these practices wherein complex and interrelated processes of discrimination take place that are based on both disability and gender. The findings demonstrate that the social workplace functions as a male bastion, in which the oversized overalls that women are forced to wear are symbolically relevant. In conclusion, we discuss and challenge the dominance of the neo-liberal norm of economic productivity and employability.     

Limits to Concurrency*

In the global race to bring new products to market, many firms have adopted concurrent engineering as a technique to shrink development lead time. Due to the many concurrent engineering success stories in the business and engineering literature, a common misconception has grown that more concurrency is always better. The major contribution of this paper is a rigorous demonstration that limits to concurrency exist even in the simplified situation in which concurrency is modeled as the number of design modules to be executed in parallel. As complexities such as communication linkages between modules are layered onto our basic model, we show that the expected project completion time is minimized at a finite number of modules, a number that decreases with increasing problem complexity. In general, the more complex the project, the stricter the limits to concurrency. This strongly suggests that project managers should be cognizant of the potentially adverse effects of pushing concurrency too far.     

Is the Pendulum Swinging Back? Patterns of Skill Change in the Machine-Tool Industry

In this paper, we focus on the results of the Belgian Trend Study. The intention of this study was to examine the prevalence of new production concepts within the widest possible range of Belgian companies in the automobile, machine tool, chemical and clothing industries. The Trend-study aimed to answer the following questions: is the Taylorist division of labour a thing of the past ? What are the alternatives? Are shifts in the division of labour accompanied by another type of personnel policy, and do traditional industrial relations have to make way for this new approach? The methodological concept used had to guarantee that the findings at the level of each industry could be generalized. In this paper, we examine the penetration of new production concepts in the main processing fields of the machine tool industry.     

Efficient Estimation of Average Treatment Effects Using the Estimated Propensity Score

We are interested in estimating the average effect of a binary treatment on a scalar outcome. If assignment to the treatment is exogenous or unconfounded, that is, independent of the potential outcomes given covariates, biases associated with simple treatment‐control average comparisons can be removed by adjusting for differences in the covariates. Rosenbaum and Rubin (1983) show that adjusting solely for differences between treated and control units in the propensity score removes all biases associated with differences in covariates. Although adjusting for differences in the propensity score removes all the bias, this can come at the expense of efficiency, as shown by Hahn (1998), Heckman, Ichimura, and Todd (1998), and Robins, Mark, and Newey (1992). We show that weighting by the inverse of a nonparametric estimate of the propensity score, rather than the true propensity score, leads to an efficient estimate of the average treatment effect. We provide intuition for this result by showing that this estimator can be interpreted as an empirical likelihood estimator that efficiently incorporates the information about the propensity score.     

Marginal Correlation from Logit- and Probit-Beta-Normal Models for Hierarchical Binary Data

In hierarchical data settings, be it of a longitudinal, spatial, multi-level, clustered, or otherwise repeated nature, often the association between repeated measurements attracts at least part of the scientific interest. Quantifying the association frequently takes the form of a correlation function, including but not limited to intraclass correlation. Vangeneugden et al. (2010 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C., Sotto, C. (2010). Marginal correlation in longitudinal binary data based on generalized linear mixed models. Communi. Stati. Theory &; Methods. 39:3542–3557. [Google Scholar]) derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models. Here, we consider the extended model family proposed by Molenberghs et al. (2010 Molenberghs, G., Verbeke, G., Demétrio, C., Vieira, A. (2010). A family of generalized linear models for repeated measures with normal and conjugate random effects. Stat. Sci. 25:325–347.[Crossref], [Web of Science ®] , [Google Scholar]). This family flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. The family allows for closed-form means, variance functions, and correlation function, for a variety of outcome types and link functions. Unfortunately, for binary data with logit link, closed forms cannot be obtained. This is in contrast with the probit link, for which such closed forms can be derived. It is therefore that we concentrate on the probit case. It is of interest, not only in its own right, but also as an instrument to approximate the logit case, thanks to the well-known probit-logit ‘conversion.’ Next to the general situation, some important special cases such as exchangeable clustered outcomes receive attention because they produce insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. (2010 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C., Sotto, C. (2010). Marginal correlation in longitudinal binary data based on generalized linear mixed models. Communi. Stati. Theory &; Methods. 39:3542–3557. [Google Scholar]) and with approximations derived for the so-called logistic-beta-normal combined model. A simulation study explores performance of the method proposed. Data from a schizophrenia trial are analyzed and correlation functions derived.