To develop a quantitative exposure‐response relationship between concentrations and durations of inhaled diesel engine exhaust (DEE) and increases in lung cancer risks, we examined the role of temporal factors in modifying the estimated effects of exposure to DEE on lung cancer mortality and characterized risk by mine type in the Diesel Exhaust in Miners Study (DEMS) cohort, which followed 12,315 workers through December 1997. We analyzed the data using parametric functions based on concepts of multistage carcinogenesis to directly estimate the hazard functions associated with estimated exposure to a surrogate marker of DEE, respirable elemental carbon (REC). The REC‐associated risk of lung cancer mortality in DEMS is driven by increased risk in only one of four mine types (limestone), with statistically significant heterogeneity by mine type and no significant exposure‐response relationship after removal of the limestone mine workers. Temporal factors, such as duration of exposure, play an important role in determining the risk of lung cancer mortality following exposure to REC, and the relative risk declines after exposure to REC stops. There is evidence of effect modification of risk by attained age. The modifying impact of temporal factors and effect modification by age should be addressed in any quantitative risk assessment (QRA) of DEE. Until there is a better understanding of why the risk appears to be confined to a single mine type, data from DEMS cannot reliably be used for QRA. 相似文献
A two-mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time-dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors. 相似文献
This paper analyzes the coordination challenge a partial cartel faces when payoff asymmetries between potential cartel insiders and potential cartel outsiders are large. We introduce two experimental treatments: a standard treatment where a complete cartel can be supported in a Nash equilibrium and a modified treatment where a complete cartel and a partial cartel can both be supported in a Nash equilibrium. To assess the role of communication both treatments are additionally run with a “chat option,” yielding four treatments in total. Our results show that subjects frequently reject the formation of partial cartels in the modified treatments. In all treatments with communication subjects are more likely to form complete cartels than partial cartels. The implications of these results are important for antitrust: payoff asymmetries between cartel members and outsiders may jeopardize the formation of partial cartels. Yet complete cartels may be formed instead, if institutional mechanisms with frequent communication are used to form cartels.
The autoregressive conditional intensity model proposed by Russell (1998) is a promising option for fitting multivariate high frequency irregularly spaced data. The authors acknowledge the validity of this model by showing the independence of its generalized residuals, a crucial assumption of the model formulation not readily recognized by researchers. The authors derive the large‐sample distribution of the autocorrelations of the generalized residual series and use it to construct a goodness‐of‐fit test for the model. Empirical results compare the performance of their test with other off‐the‐shelf tests such as the Ljung–Box test. They illustrate the use of their test with transaction records of the HSBC stock. 相似文献
Symmetry and separability of a covariance function are common assumptions to simplify the modeling effort of spatial–temporal processes. However, many studies in environmental sciences show that real data have complex spatial–temporal dependency structures resulting from lack of symmetry or violation of other standard assumptions of the covariance function. In this study, we propose new formal tests for lack of symmetry by using spectral representations of the spatial–temporal covariance functions of regularly spaced spatial–temporal data. The advantage of the proposed tests is that classical analysis of variance (ANOVA) models can be used for detecting lack of symmetry inherent in spatial–temporal processes. We evaluate the performance of the tests with simulation studies and we apply them to air pollution data. 相似文献