Point estimation after early stopping in a repeated measures trial

When the individual measurements are statistically independent, the maximum likelihood estimator calculated at the end of a sequential procedure overestimates the underlying effect. There are many clinical trials in which we are interested in comparing changes in responses between two treatment groups sequentially. Lee and DeMets (1991, JASA 86, 757–762) proposed a group sequential method for comparing rates of change when a response variable is measured for eaeh patient at successive follow-up visits. They assumed that the response follows the linear mixed effects model and derived the asymptotic joint distribution of the sequentially computed statistics. In this article, we consider the maximum likelihood estimator (MLE), the median unbiased estimator (MUE) and the midpoint of a 100(1-α)% confidence interval as point estimators for the rate of change in the linear mixed effects model, and investigate their properties by Monte Carlo simulation.     

A New Control Scheme Always Better Than X-Bar Chart

A new control scheme is proposed by borrowing the idea of the Benjamini–Hochberg procedure for controlling the false discovery rate in multiple testing. It is shown theoretically that the proposed 2-span control scheme outperforms the Shewhart X-bar chart in terms of the average run length under any size of mean shifts. Some simulations are carried out to demonstrate that the proposed scheme having various span sizes always outperforms the X-bar chart in terms of the average run lengths.     

A Design of s Control Charts with a Combined Double Sampling and Variable Sampling Interval Scheme

In this paper, we propose new estimation techniques in connection with the system of S-distributions. Besides “exact” maximum likelihood (ML), we propose simulated ML and a characteristic function-based procedure. The “exact” and simulated likelihoods can be used to provide numerical, MCMC-based Bayesian inferences.     

A new generalized normal distribution: Properties and applications

Abstract

The most commonly studied generalized normal distribution is the well-known skew-normal by Azzalini. In this paper, a new generalized normal distribution is defined and studied. The distribution is unimodal and it can be skewed right or left. The relationships between the parameters and the mean, variance, skewness, and kurtosis are discussed. It is observed that the new distribution has a much wider range of skewness and kurtosis than the skew-normal distribution. The method of maximum likelihood is proposed to estimate the distribution parameters. Two real data sets are applied to illustrate the flexibility of the distribution.     

Graphical methods for comparing confounding in two or more designs

In many circumstances it is necessary to design an experiment with partial confounding of parameter estimates. In this situation, one would like to have tools to assess and compare candidate designs graphically. In this paper we discuss two graphical representations of design properties, and illustrate their application with two examples.     

Test for Parameter Change in Linear Processes Based on Whittle's Estimator

In this article, we develop a cusum test for testing for parameter changes in linear processes based on Whittle's estimator. It is shown that under regularity conditions, the test statistic converges to the sup of a Brownian bridge. The result is particularly useful in handling the change point test in stationary ARMA processes. A simulation result is provided for illustration.     

A review of model selection procedures relevant to the weibull distribution

A number of goodness-of-fit and model selection procedures related to the Weibull distribution are reviewed. These procedures include probability plotting, correlation type goodness-of-fit tests, and chi-square goodness-of-fit tests. Also the Kolmogorow-Smirniv, Kuiper, and Cramer-Von Mises test statistics for completely specified hypothesis based on censored data are reviewed, and these test statistics based on complete samples for the unspecified parameters case are considered. Goodness-of-fit tests based on sample spacings, and a goodness-of-fit test for the Weibull process, is also discussed.

Model selection procedures for selecting between a Weibull and gamma model, a Weibull and lognormal model, and for selecting from among all three models are considered. Also tests of exponential versus Weibull and Weibull versus generalized gamma are mentioned.     

A note on the satterthwaite confidence interval for a variance

When using a Satterthwaite chi-squared approximation, it is generally thought that the approximation is satisfactory when it is applied to a positive linear combination of mean squares. In this note, we describe how the Williams - Tukey idea for getting a confidence interval for the among groups variance in a random one-way model can be incorporated into Satterthwaite’s procedure for getting a confidence interval for a variance. This adjusted Satterthwaite procedure insures that his chi-squared approximation is always applied to positive linear combinations of mean squares. A small simulation is included which suggests that the adjustment to the Satterthwaite procedure is effective.     

Estimating the discovery rate in a continuous time recapture model

We consider a family of marked Poisson process models for the discovery of distinct errors in a computer program and also for sampling, in continu-ous time, a population containing an unknown number of distinct biological species. Captures (selections or discoveries) are assumed to occur at a con-stant rate, each event consisting of the discovery of a distinct process (error or species) or the recurrence of a previously discovered process. Using a generalization of Nayak’s (1988) model we derive confidence limits for the discovery rate. The limits are based on the asymptotic distribution of a scaled logarithmic function of the maximum likelihood estimator.