Replenishing the pipeline: A quantitative approach to optimising the sourcing of new projects

Large pharmaceutical companies maintain a portfolio of assets, some of which are projects under development while others are on the market and generating revenue. The budget allocated to R&D may not always be sufficient to fund all the available projects for development. Much attention has been paid to the selection of optimal subsets of available projects to fit within the available budget. In this paper, we argue the need for a forward-looking approach to portfolio decision-making. We develop a quantitative model that allows the portfolio management to evaluate the need for future inflow of new projects to achieve revenue at desired levels, often aspiring to a certain annual revenue growth. Optimisation methods are developed for the presented model, allowing an optimal choice of number, timing and type of projects to be added to the portfolio. The proposed methodology allows for a proactive approach to portfolio management, prioritisation, and optimisation. It provides a quantitatively based support for strategic decisions regarding the efforts needed to secure the future development pipeline and revenue stream of the company.     

Feminization of refugee: Intersectionality,solidarity, resistance

This work aims to examine a possible change of feminist civil society pertaining to inclusivity with a particular interest in violence. It evaluates state-civil society relations, coping mechanisms with domestic violence and solidarity patterns with female refugees. It proposes a novel theoretical contribution, ‘feminization of refugee’ suggesting a positive shift in the empowerment of refugee women through bidirectional solidarity, intersectionality and resistance which consequently diversifies and invigorates the civil society itself. The findings suggest that the manifestation of a resistant civil society in Turkey inclined to withhold a strong feminist stance with a rights-based approach. The findings further manifest a growing need towards shelters in the pandemic experience which recalls capacity building requirements of civil society for refugee women against violence.     

A copula-based multivariate hidden Markov model for modelling momentum in football

AStA Advances in Statistical Analysis - We investigate the potential occurrence of change points—commonly referred to as “momentum shifts”—in the dynamics of football...