The relationship between circulating testosterone and inflammatory cytokines in men

Testosterone is the predominant gonadal androgen in men. Low testosterone levels are found to be associated with an increased in metabolic risk and systematic inflammation. Since adipose tissue is a source of inflammatory cytokines, testosterone may regulate inflammation by acting on adipose tissue. This review aimed to explore the role of testosterone in inflammation and its mechanism of action. Both animal studies and human studies showed that (1) testosterone deficiency was associated with an increase in pro-inflammatory cytokines; (2) testosterone substitution reduced pro-inflammatory cytokines. The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Despite these, some studies also reported a non-significant relationship. In conclusion, testosterone may possess anti-inflammatory properties but its magnitude is debatable. More evidence is needed to validate the use of testosterone as a marker and in the management of chronic inflammatory diseases.     

Financial crises and bank failures: A review of prediction methods

In this article we provide a summary of empirical results obtained in several economics and operations research papers that attempt to explain, predict, or suggest remedies for financial crises or banking defaults; we also outline the methodologies used in them. We analyze financial and economic circumstances associated with the US subprime mortgage crisis and the global financial turmoil that has led to severe crises in many countries. The intent of this article is to promote future empirical research for preventing bank failures and financial crises.     

Ethics in context: essential flexibility in an international photo-elicitation project with children and young people

ABSTRACT

Existing literatures have discussed both ethical issues in visual research with young people, and the problems associated with applying ‘universal’ ethical guidelines across varied cultural contexts. There has been little consideration, however, of specific issues raised in projects where visual research is being conducted with young people simultaneously in multiple national contexts. This paper contributes to knowledge in this area. We reflect on our experiences of planning and conducting the International CYCLES project involving photo elicitation with young people in Bangladesh, Brazil, India, Japan, New Zealand, South Africa and the UK. While some issues such as varying access to technology for taking and sharing photos and diverse cultural sensitivities around the use of photography were anticipated in advance, others were more unexpected. Balancing the need for methods to be appropriate, ethical and feasible within each setting with the desire for sufficient consistency across the project is challenging. We argue that an ‘ethics in context’ approach and an attitude of ‘methodological immaturity’ is critical in international visual research projects with young people.     

Functioning of self‐help groups in India: Members’ perceptions of key issues

Self‐help group‐bank linkage program is considered a powerful tool for eradicating poverty in many poor and developing countries, especially in Asia. The number of these groups has increased rapidly during the last few years; however, their efficacy to achieve long‐term poverty alleviation has been questioned by many researchers. Previous studies have focused mainly on objective indicators to understand the program's impact on the lives of its members, such as changes in the economic condition and the development of conceptual frameworks. The present study primarily focuses on member perceptions of the overall functioning of the self‐help group. A questionnaire survey was administered to 15 presidents and 75 group members belonging to 15 self‐help groups with active bank accounts in Chandigarh, a union territory of India. Drawing on their responses and perceptions, the five major problems faced by these groups were identified as: (i) ineffective group meetings, (ii) absence of income‐generating activities, (iii) lack of cooperation among members, (iv) lack of awareness, and (v) minimal savings. Our key recommendations include: (i) increased organizational support, (ii) focus on skill development, (iii) training and motivation, (iv) effective leadership, and (v) regular meetings.     

Kyrgyzstan’s Dordoi and Kara-Suu Bazaars: Mobility,Globalization and Survival in Two Central Asian Markets

Despite modest economic indicators, Kyrgyzstan boasts two of Eurasia’s largest bazaars: Dordoi bazaar in the capital city Bishkek, and Kara-Suu bazaar in southern Kyrgyzstan. Combined, the 2 bazaars provide employment to approximately 75,000 people and serve as entrepôts for foreign merchandise into Central Asia and Russia. This paper makes three arguments: (i) mobility of people, merchandise, capital, and information became a defining feature of the two bazaars after the collapse of the Soviet Union; (ii) Dordoi and Kara-Suu are not static institutions, as bazaars were frequently considered by post-war social sciences. Instead, Dordoi and Kara-Suu are illustrative of Kyrgyzstan’s adaptation to globalization through a transnational commercial web extending between Dubai, Guangzhou, Istanbul, Moscow, Urumchi, and smaller localities in between, making the bazaars uniquely globalized spaces; and (iii) bazaar-based trade was, and remains a critical survival mechanism given the dearth of other vocational opportunities after the collapse of the Soviet Union.     

Assessing Euro 2020 Strategy Using Multi-criteria Decision Making Methods: VIKOR and TOPSIS

Social Indicators Research - The European Union (EU) 2020 Strategy aims at forming the conditions for smart, sustainable and inclusive growth targets. Assessment of the EU countries’...     

Discerning self‐interested behaviour in attitudes towards welfare state responsibilities across Europe

Baslevent C, Kirmanoglu H. Discerning self‐interested behaviour in attitudes towards welfare state responsibilities across Europe Int J Soc Welfare 2011: 20: 344–352 © 2010 The Author(s), International Journal of Social Welfare © 2010 Blackwell Publishing Ltd and the International Journal of Social Welfare. This article reports on an investigation into the influence of individual characteristics on attitudes to government responsibility for welfare‐related tasks using data from the European Social Survey. The main finding of this investigation was that socio‐demographic characteristics, basic personal values, a left–right ideological position and religious affiliation were all associated with attitudes towards welfare policies. An item‐by‐item examination of the six issues enquired about in the survey revealed that people tended to hold the government responsible for tasks that would benefit them more directly. Taken as a whole, the empirical findings were interpreted to mean that individuals' tastes for welfare state policies were driven, at least partially, by self‐interest, but it was also noted that further work was needed to disentangle the potential role of group loyalty effects.     

Confidence intervals for the mean and a percentile based on zero-inflated lognormal data

The problems of estimating the mean and an upper percentile of a lognormal population with nonnegative values are considered. For estimating the mean of a such population based on data that include zeros, a simple confidence interval (CI) that is obtained by modifying Tian's [Inferences on the mean of zero-inflated lognormal data: the generalized variable approach. Stat Med. 2005;24:3223—3232] generalized CI, is proposed. A fiducial upper confidence limit (UCL) and a closed-form approximate UCL for an upper percentile are developed. Our simulation studies indicate that the proposed methods are very satisfactory in terms of coverage probability and precision, and better than existing methods for maintaining balanced tail error rates. The proposed CI and the UCL are simple and easy to calculate. All the methods considered are illustrated using samples of data involving airborne chlorine concentrations and data on diagnostic test costs.