A scientist's viewpoint on promoting effective use of experimental design: Ten things a scientist wants to know about experimental design

This paper tackles the practical application of statistical tools. Chemical development is a rich area for collaboration between statisticians and chemists, but most statisticians encounter difficulties in promoting the tools to this client group. This paper, presented from a chemist's perspective, is intended to help bridge the gap between the two professions. The paper explores differences in uptake and attitudes towards adopting these techniques and suggests what has hindered or helped the process of effective application of experimental design. Copyright © 2003 John Wiley & Sons, Ltd.     

Consideration of Background Exposures in the Management of Hazardous Waste Sites: A New Approach to Risk Assessment

The current approach to health risk assessment of toxic waste sites in the U.S. may lead to considerable expenditure of resources without any meaningful reduction in population exposure. Risk assessment methods used generally ignore background exposures and consider only incremental risk estimates for maximally exposed individuals. Such risk estimates do not address true public health risks to which background exposures also contribute. The purpose of this paper is to recommend a new approach to risk assessment and risk management concerning toxic waste sites. Under this new approach, which we have called public health risk assessment, chemical substances would be classified into a level of concern based on the potential health risks associated with typical national and regional background exposures. Site assessment would then be based on the level of concern for the particular pollutants involved and the potential contribution of site contaminants to typical background human exposures. While various problems can be foreseen with this approach, the key advantage is that resources would be allocated to reduce the most important sources of human exposure, and site remediation decisions could be simplified by focussing on exposure assessment rather than questionable risk extrapolations.     

Interrelationships between fertility and marital dissolution: Results of a simultaneous logit model

Previous studies have failed to examine (a) the simultaneity of decisions to bear children and to dissolve a marriage and (b) the effects of the childbearing in the period just before dissolution on the likelihood of disruption. We attempted to resolve both problems by developing a simultaneous logit model of the interrelationship between the probability of separation and of having a birth during this period (when dissolution presumably is being considered). The model was estimated at successive durations of first marriage, using data for white women in the 1970 National Fertility Survey. The results indicate that childbearing patterns— number of children and age of youngest child at the beginning of the marital interval being studied and fertility during the interval—did not influence the likelihood of separation in simple or consistent ways over the marital life course, nor did marital strife (as indicated by separation) seem to affect childbearing throughout marriage.     

School-based interventions with depressed minority adolescents

School-based approaches to intervention with depressed minority adolescents is discussed within a preventive framework. The symptomatology and epidemiology of depression is presented as it pertains to minority group adolescents. Specific suggestions for school-based services, the uses of school-based mental health professionals, and for coordination with mental health agencies are provided.