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291.
This article deals with a semisupervised learning based on naive Bayes assumption. A univariate Gaussian mixture density is used for continuous input variables whereas a histogram type density is adopted for discrete input variables. The EM algorithm is used for the computation of maximum likelihood estimators of parameters in the model when we fix the number of mixing components for each continuous input variable. We carry out a model selection for choosing a parsimonious model among various fitted models based on an information criterion. A common density method is proposed for the selection of significant input variables. Simulated and real datasets are used to illustrate the performance of the proposed method. 相似文献
292.
Inferences are made concerning population proportions when data are not missing at random.Both one sample and two sample situations are considered with examples in clinical trials.The one samplesituation involves the existence of response related incomplete data in a study conducted to make inferences involving the proportion. The two sample problem involves comparing two treatments in clinical trials when there exists dropouts due to both the treatment and the response to the treatment.Bayes procedures are used in estimating parameters of interest and testing hypotheses of interest in these two situations. An ad-hoc approach to the classical inference is presented for each ofthe two situations and compared with the Bayesian approach discussed. To illustrate the theory developed, data from clinical trials of severe head trauma patients at the Medical College of Virginia Head Injury Center from 1984 to 1987 is considered 相似文献
293.
ByoungSeon Choi 《统计学通讯:理论与方法》2013,42(8):2815-2827
It is shown that the inverse of a block Toeplitz matrix can be factored into a product of an upper block triangular, a block diagonal and a lower block triangular matrices, where the component matrices consist of the solutions of the forward and backward extended Yule-Walker equations. Also, a recursive algorithm is presented to decompose nested Toeplitz matrices, which is a generalization of the Levinson-Durbin algorithm. Its derivation is elementary. The decomposition and the algorithm are useful for solving a block Toeplitz system of simultaneous equations, particularly, which appears in the vector autoregressive moving-average model analysis. 相似文献
294.
Joint models with shared Gaussian random effects have been conventionally used in analysis of longitudinal outcome and survival endpoint in biomedical or public health research. However, misspecifying the normality assumption of random effects can lead to serious bias in parameter estimation and future prediction. In this paper, we study joint models of general longitudinal outcomes and survival endpoint but allow the underlying distribution of shared random effect to be completely unknown. For inference, we propose to use a mixture of Gaussian distributions as an approximation to this unknown distribution and adopt an Expectation–Maximization (EM) algorithm for computation. Either AIC and BIC criteria are adopted for selecting the number of mixtures. We demonstrate the proposed method via a number of simulation studies. We illustrate our approach with the data from the Carolina Head and Neck Cancer Study (CHANCE). 相似文献
295.
Competing risks are common in clinical cancer research, as patients are subject to multiple potential failure outcomes, such as death from the cancer itself or from complications arising from the disease. In the analysis of competing risks, several regression methods are available for the evaluation of the relationship between covariates and cause-specific failures, many of which are based on Cox’s proportional hazards model. Although a great deal of research has been conducted on estimating competing risks, less attention has been devoted to linear regression modeling, which is often referred to as the accelerated failure time (AFT) model in survival literature. In this article, we address the use and interpretation of linear regression analysis with regard to the competing risks problem. We introduce two types of AFT modeling framework, where the influence of a covariate can be evaluated in relation to either a cause-specific hazard function, referred to as cause-specific AFT (CS-AFT) modeling in this study, or the cumulative incidence function of a particular failure type, referred to as crude-risk AFT (CR-AFT) modeling. Simulation studies illustrate that, as in hazard-based competing risks analysis, these two models can produce substantially different effects, depending on the relationship between the covariates and both the failure type of principal interest and competing failure types. We apply the AFT methods to data from non-Hodgkin lymphoma patients, where the dataset is characterized by two competing events, disease relapse and death without relapse, and non-proportionality. We demonstrate how the data can be analyzed and interpreted, using linear competing risks regression models. 相似文献
296.
Variable time work is no longer abnormal in the post-industrial economy and is accelerating due to digitisation and the COVID-19 pandemic. Previous studies have revealed a causal relationship between working time variability and work–life balance at the individual level; however, there has been less discussion of the role of the institutional context. This study examines the interplay among childcare policy, schedule control, and its relationship with work–life balance. We conducted a multilevel analysis using the European Working Conditions Survey. The analyses revealed that childcare policy has a U-shaped relationship with work–life balance for female variable time workers without schedule control. In contrast, workers with schedule control and male workers did not have a curvilinear relationship with the outcome. Our analyses imply that sufficient childcare intervention and its interaction with schedule control are necessary to offset the negative effect of childcare services on work–life balance. 相似文献