Androgens, apoE, and Alzheimer's disease

Increasing evidence indicates that there are reductions in estrogen and androgen levels in aged men and women. These hormonal reductions might be risk factors for cognitive impairments and the development of Alzheimer's disease (AD). Aged people show improved cognition after treatments with sex steroids. Therefore, ongoing clinical AD trials have been designed to evaluate the potential benefits of estrogen therapy in women and testosterone therapy in men. Apolipoprotein E (apoE) plays an important role in the metabolism and redistribution of lipoproteins and cholesterol. The three major human apoE isoforms, apoE2, apoE3, and apoE4, differ in their effects on AD risk and pathology. Here I review various mechanisms proposed to mediate the differential effects of apoE isoforms on brain function and highlight the potential contribution of detrimental isoform-dependent effects of apoE on androgen- and androgen receptor (AR)-mediated pathways. I also discuss potential interactions of androgens with other AD-related factors.     

Notes and Comments the Amsterdam Auction

The Amsterdam auction has been used to sell real estate in the Dutch capital for centuries. By awarding a premium to the highest losing bidder, the Amsterdam auction favors weak bidders without having the implementation difficulties of Myerson's (1981) optimal auction. In a series of experiments, we compare the standard first‐price and English auctions, the optimal auction, and two variants of the Amsterdam auction. With strongly asymmetric bidders, the second‐price Amsterdam auction raises substantially more revenues than standard formats and only slightly less than the optimal auction.     

Civil Society in ‘Politics’ and ‘Development’ in African Hybrid Regimes: The Kenyan Case

VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Civil society in Gramscian conception is an arena of hegemonic contestations and therefore essentially political....     

Estimation bias and bias correction in reduced rank autoregressions

This paper characterizes the finite-sample bias of the maximum likelihood estimator (MLE) in a reduced rank vector autoregression and suggests two simulation-based bias corrections. One is a simple bootstrap implementation that approximates the bias at the MLE. The other is an iterative root-finding algorithm implemented using stochastic approximation methods. Both algorithms are shown to be improvements over the MLE, measured in terms of mean square error and mean absolute deviation. An illustration to US macroeconomic time series is given.     

A program to support the construction and evaluation of resilience indicators

The main objective of this work is to propose a method and a tool to support the development of indicators able to inform an organization about the state of its resilience through a cyclical process of identifying its resilience factors, proposing resilience indicators, assessing its organizational resilience followed by assessing and improving the resilience indicators. The research uses concepts from complex adaptive systems and from resilience engineering to establish an initial set of indicators able to assess elements that contribute to organizational resilience, and structures them temporarily as a hierarchy. A software application to support indicator definition and structuring, questionnaire generation, and result assessment activities was built to assist in speeding up the experiment-adjust cycle. Prototype indicators were instantiated with helicopter operating companies in mind, and were reviewed by a domain expert.     

Personal wellbeing among ethnic Koreans in China's Northeast

This study investigates personal wellbeing among a sample of ethnic Koreans in China's Northeast using the eight-item Personal Wellbeing Index (PWI). The PWI demonstrated good psychometric properties, consistent with previous studies. The data revealed a moderate level of personal wellbeing (PWI score = 70.3) and the results supported the Theory of Subjective Wellbeing Homeostasis, suggesting that strong external and internal buffers protect the HPM for ethnic Koreans, despite the onslaught of marketisation and urbanisation in China that are threatening to undermine Koreans' sense of ethnic identity. The predictors of personal wellbeing were found to be age (with a nonlinear relationship), education, gender, income, marital status and the city in which the individual lives.     

Gaming–playing on social media: using the psychoanalytic concept of ‘playing’ to theorize user labour on Facebook

ABSTRACT

Political economists have argued that user activity on corporate social media is regarded as labour that appears playful and fun but is exploited and sold to advertisers for profit maximization. This article begins with the working assumption that such user labour on social media constitutes a form of playing. It is theorized through a psychoanalytic perspective on the term as developed by D. W. Winnicott and André Green. The notion of gaming–playing is put forward to account for set interface structures on Facebook that resemble a game as well as free-flowing dimensions more akin to playing. Some user discourses on Facebook are analysed through this prism. A psychoanalytic conceptualization of user labour as playing allows one to analyse both positive discourses that emphasize Facebook as a space for creativity, exploration and the unknown, as well as negative discourses that critique the platform with regard to lacking privacy controls or data ownership. Both discourses are conducted in a playful manner that creatively utilize a sense of user agency in relation to others and Facebook itself, but often remain without consequences.     

Declining employment success of immigrant males in Sweden: Observed or unobserved characteristics?

Focusing on Nordic and Yugoslavian immigrant males, we study the determinants of employment success of natives and immigrants in Sweden. Furthermore, we investigate the reasons behind the arising gap in employment success between Swedes and immigrants from 1970 to 1990. In a decomposition analysis, we find that the main part of the decline in the employment probability of immigrants relative to Swedes over time is explained by a change in coefficients (unobserved characteristics) rather than a change in determinants (observed characteristics). Received: 22 June 1998/Accepted: 23 March 2000