Attribution of tumour lethality and estimation of the time to onset of occult tumours in the absence of cause-of-death Information

A new statistical approach is developed for estimating the carcinogenic potential of drugs and other chemical substances used by humans. Improved statistical methods are developed for rodent tumorigenicity assays that have interval sacrifices but not cause-of-death data. For such experiments, this paper proposes a nonparametric maximum likelihood estimation method for estimating the distributions of the time to onset of and the time to death from the tumour. The log-likelihood function is optimized using a constrained direct search procedure. Using the maximum likelihood estimators, the number of fatal tumours in an experiment can be imputed. By applying the procedure proposed to a real data set, the effect of calorie restriction is investigated. In this study, we found that calorie restriction delays the tumour onset time significantly for pituitary tumours. The present method can result in substantial economic savings by relieving the need for a case-by-case assignment of the cause of death or context of observation by pathologists. The ultimate goal of the method proposed is to use the imputed number of fatal tumours to modify Peto's International Agency for Research on Cancer test for application to tumorigenicity assays that lack cause-of-death data.     

Modified regression coefficient analysis for repeated binary measurements

Myers & Broyles (2000a, 2000b) illustrate that regression coefficient analysis (RCA) is a viable alternative to a generalized estimating equation (GEE) in the analysis of correlated binomial data. Since the regression coefficients (b i ' s ) may have different precisions, we modify RCA by weighting b i ' s by the inverses of their variances for statistical optimality. We perform the simulation study to evaluate the performance of RCA, modified RCA and GEE in terms of empirical type I errors and empirical powers of the regression coefficients in repeated binary measurement designs with and without dropouts. Two thousand data sets are generated using autoregressive (AR(1)) and compound symmetry (CS) correlation structures. We compare the type I errors and powers of RCA, modified RCA and GEE for the analysis of repeated binary measurement data as affected by different dropout mechanisms such as random dropouts and treatment dependent dropouts.     

Comparison of telephone RDD and online panel survey modes on CPGI scores and co-morbidities

The purpose of this study was to compare the influence of two survey modes – telephone random digit dialling (RDD) and stratified sampling of an online panel – on Canadian Problem Gambling Index (CPGI) scores and co-morbidities. An identical gambling survey was administered to 4000 South Koreans selected via random dialling of cell phone numbers and to 4330 South Korean members of an online panel. The online panelists were found to have significantly higher levels of tobacco use, drug or alcohol problems and mental health problems, higher employment status and lower happiness levels. However, even when controlling for these variables, CPGI scores for the online panel were significantly higher than those for the telephone interview. This appears to be due to higher levels of pathology among online panelists combined with potentially more valid self-reports due to enhanced anonymity.     

Eigenvalue Ratio Test for the Number of Factors

This paper proposes two new estimators for determining the number of factors (r) in static approximate factor models. We exploit the well‐known fact that the r largest eigenvalues of the variance matrix of N response variables grow unboundedly as N increases, while the other eigenvalues remain bounded. The new estimators are obtained simply by maximizing the ratio of two adjacent eigenvalues. Our simulation results provide promising evidence for the two estimators.     

Automated measurement of infant and mother Duchenne facial expressions in the Face-to-Face/Still-Face

Although still-face effects are well-studied, little is known about the degree to which the Face-to-Face/Still-Face (FFSF) is associated with the production of intense affective displays. Duchenne smiling expresses more intense positive affect than non-Duchenne smiling, while Duchenne cry-faces express more intense negative affect than non-Duchenne cry-faces. Forty 4-month-old infants and their mothers completed the FFSF, and key affect-indexing facial Action Units (AUs) were coded by expert Facial Action Coding System coders for the first 30 s of each FFSF episode. Computer vision software, automated facial affect recognition (AFAR), identified AUs for the entire 2-min episodes. Expert coding and AFAR produced similar infant and mother Duchenne and non-Duchenne FFSF effects, highlighting the convergent validity of automated measurement. Substantive AFAR analyses indicated that both infant Duchenne and non-Duchenne smiling declined from the FF to the SF, but only Duchenne smiling increased from the SF to the RE. In similar fashion, the magnitude of mother Duchenne smiling changes over the FFSF were 2–4 times greater than non-Duchenne smiling changes. Duchenne expressions appear to be a sensitive index of intense infant and mother affective valence that are accessible to automated measurement and may be a target for future FFSF research.     

“Don't Cry,You're Not a Baby!”: Emotion,Role and Hierarchy in Korean Language Socialisation Practice

I examine how South Korean children learn culturally specific emotional knowledge, especially affective hierarchy and the association between emotional displays and social roles, through participation in peer talk. An analysis of children's and teachers’ everyday emotional discourses shows that children, rather than passively adopting adult emotional discourses, creatively employ a range of linguistic and communicative features regarding emotions to construct their own culture‐laden emotional world. Findings articulate the role children's peer talk has in cultural reproduction and dynamic aspects of the language socialisation processes.     

Total shift during the first passages of Markov-modulated Brownian motion with bilateral ph-type jumps: Formulas driven by the minimal solution matrix of a Riccati equation

This article describes our study of the total shift during the first passages (one-sided and two-sided exit times) of Markov-modulated Brownian motion with bilateral ph-type jumps, which is referred to as MMBM. The total shift is defined as the value of a so-called shift process at the first passage epochs of the MMBM. The shift process, introduced by Bean and O’Reilly, behaves like a continuous Markovian fluid process; that is, it increases or decreases linearly with slopes regulated by the underlying Markov process that determines the path of the MMBM. Hence, the notion of total shift, which includes the first passage times of the MMBM as special cases, is useful for describing various performance measures of systems modeled by the MMBM. In this article, we present formulas for the Laplace–Stieltjes transform matrices of the total shift during various first passages of the MMBM. In particular, a Riccati equation is derived so that a matrix associated with the Laplace–Stieltjes transform of the total shift during the first return time of the MMBM is its minimal non-negative solution matrix. With this solution matrix, the Laplace–Stieltjes transform matrices can be obtained without much additional work. Furthermore, it is shown that the Riccati equation satisfies the conditions for the Newton scheme to have quadratic convergence, which enables us to use algorithms with quadratic convergence, such as Newton’s method and the Stochastic Doubling Algorithm, to compute the presented matrix-driven formulas. For the analyses, we take an approach based on approximating the MMBM with a sequence of scaled Markov-modulated fluid flows with bilateral ph-type jumps, referred to as MMFF, that weakly converge to the MMBM. Another contribution of this article is that duality results are derived in relation to the MMBM, which is an extension of the duality theorems developed by Ahn and Ramaswami for an MMFF without a jump.     

Efficient designs for animal carcinogenicity experiments

In a typical carcinogenicity study, animals, usually rats or mice. are divided into a control and two to three dose groups of 50 or more by randomization. A chemical is administered at a constant daily dose rate for a major portion of the lifetime of the test animals, for example, two years. In general, such an experiment is expensive and time consuming In this paper, we propose an efficient design with reduced sample size and/or shortened study duration. An equal number of animals per dose group is considered in this study. A power study of the age-adjusted trend test, for the turnor incidence rate for single-sacrifice experiments proposed by Kodell et al. (Drug Information Journal, 1997) is conducted. A Monte Carlo simulation study is performed to compare the performance of the trend test for the standard design and various reduced designs. Based on the Kodell et al. test, the 21-month study duration with sample size 50 per group is recommended as the best, reduced design over the traditional 2-year study design with the same sample size.     

Distance-based outlier detection for high dimension,low sample size data

Despite the popularity of high dimension, low sample size data analysis, there has not been enough attention to the sample integrity issue, in particular, a possibility of outliers in the data. A new outlier detection procedure for data with much larger dimensionality than the sample size is presented. The proposed method is motivated by asymptotic properties of high-dimensional distance measures. Empirical studies suggest that high-dimensional outlier detection is more likely to suffer from a swamping effect rather than a masking effect, thus yields more false positives than false negatives. We compare the proposed approaches with existing methods using simulated data from various population settings. A real data example is presented with a consideration on the implication of found outliers.