Emotions into Disorder: Anxiety Disorders and the Social Meaning of Fear

This article explores what we refer to as norm-stimuli-state discrepancies, which are disparities between people's physical-emotional responses to emotional cues and the normative meanings of those cues. Drawing on forty qualitative interviews and participant observation research at support groups, we show that people with anxiety disorders describe two forms of norm-stimuli-state discrepancies. The first form involves discrepancies of type, in which people label fearful emotional states as deviant for being caused by the “wrong” stimuli. The second involves discrepancies of intensity, in which people label fearful states as deviant for involving feelings or displays of “too much” anxiety in response to an “appropriate” stimuli. The article further addresses the role of stimuli in prompting treatment seeking. Unexpected and intense emotional distress in combination with the falling away of external cues—which we refer to as “stimuli-less fear”—serve as a critical juncture on the path to an anxiety disorder diagnosis.     

Evaluating surrogate variables for improving microarray multiple testing inference

The use of surrogate variables has been proposed as a means to capture, for a given observed set of data, sources driving the dependency structure among high-dimensional sets of features and remove the effects of those sources and their potential negative impact on simultaneous inference. In this article we illustrate the potential effects of latent variables on testing dependence and the resulting impact on multiple inference, we briefly review the method of surrogate variable analysis proposed by Leek and Storey (PNAS 2008; 105:18718-18723), and assess that method via simulations intended to mimic the complexity of feature dependence observed in real-world microarray data. The method is also assessed via application to a recent Merck microarray data set. Both simulation and case study results indicate that surrogate variable analysis can offer a viable strategy for tackling the multiple testing dependence problem when the features follow a potentially complex correlation structure, yielding improvements in the variability of false positive rates and increases in power.     

Referent Group Proximity,Social Norms,and Context: Alcohol Use in a Low-Use Environment

Abstract

Objective: The purpose of this study was to investigate the relationship between perceived normative use of alcohol and reported consumption in an environment where relatively little alcohol use occurs. Participants: A total of 585 undergraduate students completed an online survey on alcohol use in March 2006. Methods: Participants reported personal alcohol use and perceptions of use by “friends,” “the average student,” and “the average student who drinks.” Results: Due to the large number of students reporting zero alcohol use, zero-inflated negative binomial regression was used to analyze the data. Results showed that perceptions of use and beliefs about the acceptability of use by proximal groups were strongly and positively correlated with personal alcohol use. Perceptions of distal groups were either not correlated or were correlated negatively with personal use. Conclusion: These findings suggest that the use of distal referent groups for a social norms campaign in a low-use environment may have paradoxical effects.     

Temporal Ordering of Intimate Relationship Efficacy and Conflict

Drawing from social cognitive theory (Bandura, 1986) and data from 1,640 couples who remained together over the first 4 waves of the German Panel Analysis of Intimate Relationships and Family Dynamics (Pairfam) project, the authors examined the temporal ordering between each partner's relationship efficacy and conflict (constructive behaviors and frequency of negative exchanges) assessed at the dyadic and individual levels. The results revealed that each partner's constructive conflict behaviors and negatively valenced conflict frequency at the couple level temporally preceded relationship efficacy for male and female partners. There was no support for the reverse order or bidirectional linkages over time. These results challenge the prevailing theoretical and empirical suppositions regarding associations between relationship efficacy and couple interactions. The discussion theorizes a more complex efficacy process in couple relations, whereas specific efficacy beliefs shape behaviors in that domain, which subsequently inform each partner's global relationship efficacy over time.     

Clinical utility estimation for assay cutoffs in early phase oncology enrichment trials

Predictive enrichment strategies use biomarkers to selectively enroll oncology patients into clinical trials to more efficiently demonstrate therapeutic benefit. Because the enriched population differs from the patient population eligible for screening with the biomarker assay, there is potential for bias when estimating clinical utility for the screening eligible population if the selection process is ignored. We write estimators of clinical utility as integrals averaging regression model predictions over the conditional distribution of the biomarker scores defined by the assay cutoff and discuss the conditions under which consistent estimation can be achieved while accounting for some nuances that may arise as the biomarker assay progresses toward a companion diagnostic. We outline and implement a Bayesian approach in estimating these clinical utility measures and use simulations to illustrate performance and the potential biases when estimation naively ignores enrichment. Results suggest that the proposed integral representation of clinical utility in combination with Bayesian methods provide a practical strategy to facilitate cutoff decision‐making in this setting. Copyright © 2015 John Wiley & Sons, Ltd.     

Criticism and outstanding leadership: An evaluation of leader reactions and critical outcomes

Outstanding political leaders are frequently called upon to make high-stakes decisions. Because of the controversial and highly visible nature of these issues, they often face intense criticism. Leaders' responses to criticisms not only affect follower reactions, but also the successful resolution of the contested issue. The present study examines leader and follower reactions to different types of criticisms. A historiometric approach was used to examine biographies containing criticisms of 120 world leaders and to explore leader behaviors in response to criticisms. Specifically, leader response strategies and their success in terms of follower reactions and resolution of the criticism were examined. The results indicated that collaborative or confrontational leader response strategies proved most effective in terms of the leader's ability to continue forward with a particular agenda item and to gather support of those around him or her. Conversely, avoidant, diverting attention, and persuasive response strategies proved less effective.     

Evaluating Scholarship Productivity in COAMFTE‐Accredited Doctoral Programs: An Update

Scholarly productivity continues to be used as a significant factor when universities make decisions about granting tenure to faculty, allocating resources, and supporting program goals. In 2009, DuPree, White, Meredith, Ruddick, and Anderson reviewed research productivity in faculty from COAMFTE‐accredited PhD programs. As an update, the purpose of this article is to re‐examine scholarly productivity trends among COAMFTE‐accredited doctoral programs through the use of several evaluation methods. Specifically, productivity was examined in the following areas: (a) family therapy journal publications; (b) publications in any type of peer‐reviewed journal; (c) h‐factor index scores; and (d) historic and recent journal publication trends.     

Hope,Coping, and Relationship Quality in Mothers of Children With Down Syndrome

Parenting a child with Down syndrome may pose unique challenges for parents’ relationship quality. This study used structural equation modeling with a sample of 351 mothers of children with Down syndrome to test if hope mediated the association between mothers’ various coping behaviors and mothers’ relationship quality. Hope was defined as a generalized positive state that comes from a personal sense of agency. Results indicated a greater degree of religious coping and internal coping were each significantly associated with more hope, whereas support seeking was not related with more hope. Higher hope was significantly associated with greater relationship quality. Bootstrapped indirect effects from both religious coping and internal coping to hope, and then hope to relationship quality, were identified. Implications for therapists and future research are described.