When the Learning Disabled Go to College

Abstract

During the last decade, federal laws have provided for remedial education in elementary and secondary schools for students with learning disabilities, preparing large numbers of them for college. Federal law also mandates helping learning-disabled students with their needs once they matriculate. Declining numbers of high school graduates in the aftermath of the baby boom have made more colleges open their doors to these students. The disabilities, and the accommodations they require, arrive in college with the rest of a student's baggage, demanding attention. Colleges and universities have chosen a variety of approaches, from specific remedial programs and individual accomodations according to need to more general programs. Some colleges pretend these disabilities do not exist and seem oblivious to their presence on campus. Learning disabilities can have an impact in every class and lecture hall and can contribute to unhappiness and the college's attrition rate. On the other hand, responsive and responsible programs provide students with the resources for the same education, honors, and opportunities as their nondisabled peers.     

Statistics in Latin America

Statistics is a relatively new discipline in Latin America. At present only sparse information is available about the state of the statistical profession in Latin America. We present and summarize the available information about the job market; training, education, and research; professional societies and their activities; and so forth. We also share our hopes, concerns, and suggestions for the future.     

A Quality Risk Management Model Approach for Cell Therapy Manufacturing

International regulatory authorities view risk management as an essential production need for the development of innovative, somatic cell‐based therapies in regenerative medicine. The available risk management guidelines, however, provide little guidance on specific risk analysis approaches and procedures applicable in clinical cell therapy manufacturing. This raises a number of problems. Cell manufacturing is a poorly automated process, prone to operator‐introduced variations, and affected by heterogeneity of the processed organs/tissues and lot‐dependent variability of reagent (e.g., collagenase) efficiency. In this study, the principal challenges faced in a cell‐based product manufacturing context (i.e., high dependence on human intervention and absence of reference standards for acceptable risk levels) are identified and addressed, and a risk management model approach applicable to manufacturing of cells for clinical use is described for the first time. The use of the heuristic and pseudo‐quantitative failure mode and effect analysis/failure mode and critical effect analysis risk analysis technique associated with direct estimation of severity, occurrence, and detection is, in this specific context, as effective as, but more efficient than, the analytic hierarchy process. Moreover, a severity/occurrence matrix and Pareto analysis can be successfully adopted to identify priority failure modes on which to act to mitigate risks. The application of this approach to clinical cell therapy manufacturing in regenerative medicine is also discussed.     

Symbols Build Communication and Thought: The Role of Gestures and Words in the Development of Engagement Skills and Social‐emotional Concepts during Toddlerhood

Social skills and symbol skills are positively associated in middle childhood, but the relation between these domains is less clear in newly verbal toddlers. Vygotsky proposed that symbols are both tools for interaction and mental tools for thought. Do symbols help even very young children build skills for interacting with and conceptualizing the social world? Longitudinal data from 108 children and mothers were collected when children were 14, 24, and 36 months. Children's gestures and words during mother–child interactions were used as symbol skill indicators to predict children's abilities to engage others and the number of social‐emotional concepts children portray during play. In a series of growth models, words had a stronger effect on engagement skills whereas early gesture use predicted later development of social‐emotional concepts. Therefore, even in early development, symbols serve as both communication tools and mental tools to construct understanding of the social‐emotional world.     

Prediction based classification for longitudinal biomarkers

Assessment of circulating CD4 count change over time in HIV-infected subjects on antiretroviral therapy (ART) is a central component of disease monitoring. The increasing number of HIV-infected subjects starting therapy and the limited capacity to support CD4 count testing within resource-limited settings have fueled interest in identifying correlates of CD4 count change such as total lymphocyte count, among others. The application of modeling techniques will be essential to this endeavor due to the typically non-linear CD4 trajectory over time and the multiple input variables necessary for capturing CD4 variability. We propose a prediction based classification approach that involves first stage modeling and subsequent classification based on clinically meaningful thresholds. This approach draws on existing analytical methods described in the receiver operating characteristic curve literature while presenting an extension for handling a continuous outcome. Application of this method to an independent test sample results in greater than 98% positive predictive value for CD4 count change. The prediction algorithm is derived based on a cohort of n = 270 HIV-1 infected individuals from the Royal Free Hospital, London who were followed for up to three years from initiation of ART. A test sample comprised of n = 72 individuals from Philadelphia and followed for a similar length of time is used for validation. Results suggest that this approach may be a useful tool for prioritizing limited laboratory resources for CD4 testing after subjects start antiretroviral therapy.     

Structure,power, and discourses of development in Spanish NGOs

Because of its recent and rapid growth, the Spanish development apparatus provides an appropriate arena for studying nongovernmental organizations (NGOs). This article uses case studies of three NGOs—Manos Unidas, Intermón Oxfam, and Madre Coraje—to explore the tension between the internal and external dynamics that affect these organizations. Although powerful external forces promote structural isomorphism with its attendant bureaucratization and professionalization, several internal factors—youth, small size, certain ideologies, charismatic leaders, and privileging identification with the organization rather than expertise when recruiting participants—resist these homogenizing processes. DiMaggio and Powell's iron cage hypothesis (1983) therefore can be only partially confirmed. We suggest an intriguing, intimate connection between charisma and democracy.     

Some special forms of aggressiveness in activity group therapy and their impact on the therapist

Internal World and External Reality: Object Relations Theory Applied. Otto F. Kernberg, M.D. (New York: Jason Aronson, 1980.)

Treatment of the Obsessive Personality. Leon Salzman. (New York: Jason Aronson, 1980.)

Social Work Practice: People and Environments. Ed. Carel P. Germain. (New York: Columbia University Press, 1979.)

The Life Model of Social Work Practice. Carel Germain and Alex Gitterman. (New York: Columbia University Press, 1980.)

Social Science Research and Decision‐Making. Carol H. Weiss. (New York: Columbia University Press, 1980.)     

It Won't Change a Thing: The Meanings of Marriage in the Netherlands

The vast body of literature that highlights the increasing fragility of marriage fails to explore the effect of this fragility on the meanings people attach to marriage. During the last twenty-five to thirty years the instrumental and normative reasons for marriage—legal protection, societal support and enforcement, the social rejection of alternatives to marriage—have largely disappeared in the Netherlands. This study focuses on how young adults, raised after the most dramatic changes in marital practices took place, talk about the meanings of marriage in the context of building intimate relationships. In-depth interviews with fifteen heterosexual young adults (aged twenty-one to thirty) who were in a committed relationship showed that they talked about marriage in four different ways. They (1) minimized the meaning of marriage, (2) talked about the idea of marriage to ascertain commitment, (3) defined marriage as the ideal relationship, and/or (4) saw marriage as a jinx. Contradictions between these modes of talk revealed feelings of ambivalence and anxiety associated with a desire for commitment. The emotionally charged meanings associated with marriage anchored marriage in interviewees' imaginations, enabling the institution to retain its hold even though social pressures to marry are limited and legal substitutes to marriage exist.     

Fertility Decline in Czechoslovakia During the Last Two Centuries

The decline of fertility in Czechoslovakia on the territory of the Czech Socialist Republic began with a rise in the age at marriage; the decline of marital fertility began only after 1860. On the territory of the Slovak Socialist Republic marital fertility began to decline after 1900 without previous significant changes in the age at marriage. The differences between the demographic behaviour in the two parts of Czechoslovakia have persisted, although they are now gradually disappearing. There are other significant regional differences in the fertility decline caused by the overall process of economic and social development. The end of the demographic transition in the Czech Socialist Republic came during the 1930's and in the Slovak Socialist Republic during the 1960's.     

Central Limit Theorem approximations for the number of runs in Markov-dependent binary sequences

We consider Markov-dependent binary sequences and study various types of success runs (overlapping, non-overlapping, exact, etc.) by examining additive functionals based on state visits and transitions in an appropriate Markov chain. We establish a multivariate Central Limit Theorem for the number of these types of runs and obtain its covariance matrix by means of the recurrent potential matrix of the Markov chain. Explicit expressions for the covariance matrix are given in the Bernoulli and a simple Markov-dependent case by expressing the recurrent potential matrix in terms of the stationary distribution and the mean transition times in the chain. We also obtain a multivariate Central Limit Theorem for the joint number of non-overlapping runs of various sizes and give its covariance matrix in explicit form for Markov dependent trials.