Maximum Likelihood Estimation for Stochastic Differential Equations with Random Effects

Abstract. We consider N independent stochastic processes (X _i (t), t ∈ [0,T _i ]), i=1,…, N, defined by a stochastic differential equation with drift term depending on a random variable φ _i . The distribution of the random effect φ _i depends on unknown parameters which are to be estimated from the continuous observation of the processes X_i. We give the expression of the exact likelihood. When the drift term depends linearly on the random effect φ _i and φ _i has Gaussian distribution, an explicit formula for the likelihood is obtained. We prove that the maximum likelihood estimator is consistent and asymptotically Gaussian, when T _i =T for all i and N tends to infinity. We discuss the case of discrete observations. Estimators are computed on simulated data for several models and show good performances even when the length time interval of observations is not very large.     

A Question of Ethics

This article identifies three consulting roles—helper, leader, and colleague; recommends that statistical consultants ask more questions about basic mechanisms; suggests that statistical consultants regard their primary responsibility as providing guidance about the scientific method itself; discusses the need for continuing education to help improve consulting skills; and describes Wisconsin's Master's degree examination, which was designed to help students become effective practicing statisticians.     

Parameter measures of skewness

Several different measures of skewness are commonly used in place of γ₁, the third central moment divided by the cube of the standard deviation. The numerical values of these measures are compared in this paper for members of the gamma, lognormal or Weibull family of distributions and shown to vary considerably in most cases even when skewness and kurtosis are moderate.