Urine-concentrating ability in the aging kidney

Urine-concentrating ability is decreased in the aging mammalian kidney. Studies have revealed various changes in kidney function that occur with aging and may explain the reduced ability to concentrate urine. Recently, the genes encoding many of the water- and solute-transport proteins and the vasopressin receptor, all of which are involved in urine concentration, have been cloned. Therefore, the molecular mechanisms that cause the reduction in urine-concentrating ability with aging can now be deciphered. In this Perspective, I discuss recent experiments designed to characterize this change in kidney function in aging mammals.     

Performance Metric Portfolios: A Framework and Empirical Analysis

The widespread adoption of supply chain management principles suggests that managers recognize the importance of evaluating operational decisions holistically. However, it is often difficult to link specific operational practices to strategic level outcomes and in turn to corporate financial results. This presents problems for both managers and academic researchers attempting to justify the often high cost of operational improvement initiatives in terms of objective accounting metrics. This study provides evidence that it is possible to demonstrate linkages between carefully chosen portfolios of tactical, strategic, and financial metrics. Survey data from 118 manufacturers are used to evaluate hypotheses linking multilevel metrics of performance across three well‐established strategic foci. We present portfolios of metrics drawn from the literature and from the Supply Chain Counciľs supply‐chain operations reference model and related design and customer chain models. Our analysis suggests that metric portfolios in which tactical metrics are designed to match strategic‐level metrics, based on alignment with a specific strategic focus, provide clearer mechanisms for understanding performance linkages.     

A queer anxiety: assimilation politics and cinematic hedonics in Relax . . . It's Just Sex

This essay explores the commodification of queer identities in independent cinema, offering particular attention to P. J. Castellaneta's 1998 film, Relax . . . It's Just Sex. Like many contemporary queer independent productions, Relax is ensnared in a representational cinematic hedonics, aspiring to sustain a traditional gay and lesbian politics and simultaneously produce pleasure for multiple audiences. While Relax attempts to position itself as a queer film that resists normative conceptions of sexuality, the feature inadvertently appropriates more essentialized understandings of identity closely aligned to liberation rhetoric.     

Client narratives about experiences with a multicouple treatment program for intimate partner violence

A handful of clinical trials have concluded that conjoint couples treatment for intimate partner violence is safe and at least as effective as conventional batterer intervention programs, yet very few researchers have explored couples' perspectives on conjoint treatment. Using qualitative narrative analysis methodology, the researchers conducted 48 client participant interviews and five staff interviews to better understand couples' experiences of a conjoint treatment program for intimate partner violence. Themes that recurred throughout participants' narratives included (a) perceptions of safety, (b) benefits received, (c) attitudinal change, (d) behavioral change, and (e) important learning. Research directions and training implications are discussed.     

Understanding "elder abuse and neglect": a critique of assumptions underpinning responses to the mistreatment and neglect of older people

This article provides an overview of the ways in which the mistreatment and neglect of older people have come to be understood as a social problem, one which is underpinned by a variety of substantive and theoretical assumptions. It connects the process of conceptualizing elder abuse and neglect to political-economic and social evolution. The authors draw on a review of the literature, government sources, interest group websites, and their own research to provide a critical commentary illustrating how these understandings have become manifest in legislation, policies, and programs pertaining to "elder abuse and neglect" in Canada. Suggestions are provided for changes in direction for policies, programs, and research.     

Male Batterers’ Alcohol Use and Gambling Behavior

Little work has examined the interrelations among intimate partner violence (IPV), alcohol use, and gambling behavior, and no studies have examined these relationships among males court-ordered to batterer intervention programs (BIPs). The aim of the current investigation was to explore the associations between IPV, alcohol use, and gambling behavior among 341 males court-mandated to attend BIPs utilizing self-report measures. Voluntary, anonymous questionnaires were administered and completed during regularly scheduled BIP sessions. Compared to the general population, a higher percentage of the sample met criteria for pathological gambling (9%), and problem gambling (17%). Further, males exhibiting pathological gambling were more likely to be hazardous drinkers, and hazardous drinkers were more likely to exhibit pathological gambling. Additionally, pathological gamblers were at an increased risk for the perpetration of both physical and sexual aggression. Finally, gambling behavior uniquely predicted the perpetration of sexual aggression above and beyond alcohol use, impulsivity, and relationship satisfaction. The implications of these results for future research and intervention are discussed.     

Neighborhood Concentrated Disadvantage and Adult Mortality: Insights for Racial and Ethnic Differences

While racial and ethnic differences in mortality are pervasive and well documented, less is known about how mortality risk varies by neighborhood socioeconomic status across racial and ethnic identity. We conducted a prospective analysis on a sample of adults living at or below 300% poverty with 8 years of the National Health Interview Survey (N = 159,400) linked to 11,600 deaths to examine the association between neighborhood disadvantage and mortality for non-Hispanic whites, non-Hispanic blacks, and U.S.- and foreign-born Hispanics. Using multilevel logistic regression, we find that the probability of death from any cause for lower-income adults is higher in more-disadvantaged neighborhoods, compared to less-disadvantaged neighborhoods, but only for whites. The adjusted likelihood of death for blacks and foreign-born Hispanics is not associated with neighborhood disadvantage, and the likelihood of death for U.S.-born Hispanics is lower in more-disadvantaged neighborhoods. While future research and policy should focus on improving health-promoting resources in all communities, care should be given to better understanding why race/ethnic groups have differential mortality returns with respect to area-specific socioeconomic conditions.     

The role of population size in the determination and prediction of population forecast errors: An evaluation using conifidence intervals for subcounty areas

Producers of population forecasts acknowledge the uncertainty inherent in trying to predict the future and should warn about the likely error of their forecasts. Confidence intervals represent one way of quantifying population forecast error. Most of the work in this area relates to national forecasts; although, confidence intervals have been developed for state and county forecasts. A few studies have examined subcounty forecast error, however, they only measured point estimates of error. This paper describes a technique for making subcounty population forecasts and for generating confidence intervals around their forecast error. It also develops statistical equations for calculating point estimates and confidence intervals for areas with different population sizes. A non-linear, inverse relationship between population size and forecast accuracy was found and we demonstrate the ability to accurately predict average forecast error and confidence intervals based on this relationship.