Type I error rates from likelihood‐based repeated measures analyses of incomplete longitudinal data

The last observation carried forward (LOCF) approach is commonly utilized to handle missing values in the primary analysis of clinical trials. However, recent evidence suggests that likelihood‐based analyses developed under the missing at random (MAR) framework are sensible alternatives. The objective of this study was to assess the Type I error rates from a likelihood‐based MAR approach – mixed‐model repeated measures (MMRM) – compared with LOCF when estimating treatment contrasts for mean change from baseline to endpoint (Δ). Data emulating neuropsychiatric clinical trials were simulated in a 4 × 4 factorial arrangement of scenarios, using four patterns of mean changes over time and four strategies for deleting data to generate subject dropout via an MAR mechanism. In data with no dropout, estimates of Δ and SE_Δ from MMRM and LOCF were identical. In data with dropout, the Type I error rates (averaged across all scenarios) for MMRM and LOCF were 5.49% and 16.76%, respectively. In 11 of the 16 scenarios, the Type I error rate from MMRM was at least 1.00% closer to the expected rate of 5.00% than the corresponding rate from LOCF. In no scenario did LOCF yield a Type I error rate that was at least 1.00% closer to the expected rate than the corresponding rate from MMRM. The average estimate of SE_Δ from MMRM was greater in data with dropout than in complete data, whereas the average estimate of SE_Δ from LOCF was smaller in data with dropout than in complete data, suggesting that standard errors from MMRM better reflected the uncertainty in the data. The results from this investigation support those from previous studies, which found that MMRM provided reasonable control of Type I error even in the presence of MNAR missingness. No universally best approach to analysis of longitudinal data exists. However, likelihood‐based MAR approaches have been shown to perform well in a variety of situations and are a sensible alternative to the LOCF approach. MNAR methods can be used within a sensitivity analysis framework to test the potential presence and impact of MNAR data, thereby assessing robustness of results from an MAR method. Copyright © 2004 John Wiley & Sons, Ltd.     

Non-ignorable missing covariate data in survival analysis: a case-study of an International Breast Cancer Study Group trial

Summary.  Non-ignorable missing data, a serious problem in both clinical trials and observational studies, can lead to biased inferences. Quality-of-life measures have become increasingly popular in clinical trials. However, these measures are often incompletely observed, and investigators may suspect that missing quality-of-life data are likely to be non-ignorable. Although several recent references have addressed missing covariates in survival analysis, they all required the assumption that missingness is at random or that all covariates are discrete. We present a method for estimating the parameters in the Cox proportional hazards model when missing covariates may be non-ignorable and continuous or discrete. Our method is useful in reducing the bias and improving efficiency in the presence of missing data. The methodology clearly specifies assumptions about the missing data mechanism and, through sensitivity analysis, helps investigators to understand the potential effect of missing data on study results.     

A class of count models and a new consistent test for the Poisson distribution

We define a class of count distributions which includes the Poisson as well as many alternative count models. Then the empirical probability generating function is utilized to construct a test for the Poisson distribution, which is consistent against this class of alternatives. The limit distribution of the test statistic is derived in case of a general underlying distribution, and efficiency considerations are addressed. A simulation study indicates that the new test is comparable in performance to more complicated omnibus tests.     

From critical sociology to public intellectual: Pierre Bourdieu and politics

By the late 1990s, Pierre Bourdieu had become the primary public intellectual of major social scientific status at the head of the anti-globalization movement that emerged in France and in other Western European countries. This article discusses how Bourdieu became a leading public intellectual, a role that seems to contrast with his early years as a professional sociologist. It explores what seemed to change in Bourdieu’s activities and outlook as sociologist and what seems to have remained constant. It identifies several institutional conditions that seemed necessary for Bourdieu to be able to play the kind of public intellectual role he did in his later years. Bourdieu’s movement from a peripheral position to a central location in the French intellectual field, the changing character of the field itself, the growing influence of the mass media in French political and cultural life, the failures of the French Socialists in power, a cultural legacy of leading critical intellectuals in France, a unifying national issue of globalization, and the political conjuncture in 1995 all intersected in ways that opened a path for Bourdieu to choose new and more frequent forms of political action. His responses to that combination of factors at different moments reveal both a striking continuity in desire to preserve the autonomy of intellectual life and a change in view and strategy on how best to do that. The article concludes with a brief evaluation of Bourdieu’s public intellectual role.     

Framing Latina/o Immigration, Education, and Activism

Although Latinas/os have a long history in the USA and represent a growing percentage of the population, they remain largely invisible or stereotyped in dominant images and discourses. Such representations are often ahistorical, and they camouflage the effects of US power and inequality. However, the spring 2006 immigrant rights demonstrations disturbed dominant conceptions. The demonstrators called attention to the contradictory US practices that disrupt home countries, recruit labor migrants, and deny immigrants full participation. Likewise, the role of students in these demonstrations spurred reflections on why youth would walk out of their schools for immigrant rights. Inspired by these demonstrations, we combine materials from multiple disciplines to emphasize the significance of US imperialism, exploitation, and exclusion on Latina/o migration, education, and activism. Key to this article is a reframing of how the media, K-12 curriculum, and popular discourse often engage in a cultural cover-up that sustains inequality.     

Projective Identification as a Contributor to Domestic Violence

Many explanations have been given as to why men batter. Rarely are deep unconscious intrapsychic processes identified as contributing reasons. One way that violent men may use their partner to fill emotional needs is through the primitive defense of projective identification. Projective identification may be invoked by men to induce the other partner to carry split off threatening parts of the self that are too anxiety provoking to retain. The occurrence of projective identification could therefore be an important intrapsychic and interpersonal dynamic that contributes to the escalation of tension prior to the violent episode.     

Consumption and Saving Behavior of Older and Younger Baby Boomers in Korea

The 1998 Korean Survey of Family Income and Expenditures was used to examine the overall consumption and saving behavior of Korean baby boomers and compared the differences in consumption and saving behavior between older and younger boomers. The t -test results indicated that the younger boomers allocated a significantly higher percentage of their expenditures on food away from home, household appliances, transportation and communication than did the older boomers, whereas the older boomers spent higher amounts and allocated larger budget shares on their children's education than did the younger boomers. The results of Ordinary Least-Squares (OLS) regression analysis showed that, holding other factors constant, older boomers not only spent significantly more in the total consumption expenditures and education expenditures, but older boomers also saved significantly less than did younger boomers.     

The Gendered Face of Terrorism

What does sociology have to contribute to our understanding of terrorism? As scholars of gender and the Far Right, we believe that we have much to offer the current debates. In this article, we focus both on contemporary cases of terrorism, the attacks of September 11 and the Oklahoma City bombing, and terrorist movements as gendered: as enactments of masculinity. In particular, we focus on the contemporary white supremacist movement, the most dangerous domestic terrorist threat faced by the USA. We suggest that the ideology and organization of many terrorist groups are saturated with gendered meanings, both as the analytic prism through which they view their situation, and also as a means of political mobilization.