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In this work we present a simple estimation procedure for a general frailty model for analysis of prospective correlated failure times. Earlier work showed this method to perform well in a simulation study. Here we provide rigorous large-sample theory for the proposed estimators of both the regression coefficient vector and the dependence parameter, including consistent variance estimators. 相似文献
63.
通过对十运会男子跳远运动员着地角、蹬地角、起跳扇面角的分析研究,认为改善此三项参数极为不合理的现状是实施训练过程的重要任务之一.继续提高运动员专项能力、更合理地安排整个训练过程,尽量避免过早的专项化训练带来的负面影响,加强膝关节快速用力条件下的退让式收缩能力和克制性收缩力量,是完成此任务的有效途径. 相似文献
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分析了网孔大薄板在机械加工过程中的受力和各种变形,提出了控制加工平面度的分区均衡对称减刚工艺原则,并在实践中得到验证。 相似文献
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This paper considers a single-machine scheduling problem to minimize the maximum lateness. The processing time of each job is a linear function of the time when the job starts processing. This problem is known to be
-hard in the literature. In this paper, we design a branch-and-bound algorithm for deriving exact solutions by incorporating several properties concerning dominance relations and lower bounds. These properties produce synergic effects in accelerating the solution finding process such that the algorithm can solve problems of 100 jobs within 1 min on average. To compose approximate solutions, we revise a heuristic algorithm available in the literature and propose several hybrid variants. Numerical results evince that the proposed approaches are very effective in successfully reporting optimal solutions for most of the test cases. 相似文献
68.
刍议民办本科高校优秀师资的引进 总被引:3,自引:0,他引:3
傅丽芳 《浙江树人大学学报》2007,7(1):16-18
论述民办本科高校引进优秀师资的重要性和迫切性,从人才观、制度和环境建设、教学与科研关系等多方面探讨如何引进优秀师资问题,提出了若干有益的对策建议。 相似文献
69.
本文论述了企业营销竞争力的内涵、自测模型及企业营销竞争力下降时出现的征兆,并分析了企业营销竞争力下降的一般原因。 相似文献
70.
Variability in PAH-DNA Adduct Measurements in Peripheral Mononuclear Cells: Implications for Quantitative Cancer Risk Assessment 总被引:2,自引:0,他引:2
Christopher Dickey Regina M. Santella Dale Hattis Deliang Tang Yanzhi Hsu Tom Cooper Tie-Lan Young Frederica P. Perera 《Risk analysis》1997,17(5):649-656
Biomarkers such as DNA adducts have significant potential to improve quantitative risk assessment by characterizing individual differences in metabolism of genotoxins and DNA repair and accounting for some of the factors that could affect interindividual variation in cancer risk. Inherent uncertainty in laboratory measurements and within-person variability of DNA adduct levels over time are putatively unrelated to cancer risk and should be subtracted from observed variation to better estimate interindividual variability of response to carcinogen exposure. A total of 41 volunteers, both smokers and nonsmokers, were asked to provide a peripheral blood sample every 3 weeks for several months in order to specifically assess intraindividual variability of polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels. The intraindividual variance in PAH-DNA adduct levels, together with measurement uncertainty (laboratory variability and unaccounted for differences in exposure), constituted roughly 30% of the overall variance. An estimated 70% of the total variance was contributed by interindividual variability and is probably representative of the true biologic variability of response to carcinogenic exposure in lymphocytes. The estimated interindividual variability in DNA damage after subtracting intraindividual variability and measurement uncertainty was 24-fold. Inter-individual variance was higher (52-fold) in persons who constitutively lack the Glutathione S-Transferase M1 (GSTM1) gene which is important in the detoxification pathway of PAH. Risk assessment models that do not consider the variability of susceptibility to DNA damage following carcinogen exposure may underestimate risks to the general population, especially for those people who are most vulnerable. 相似文献