The zero-inflated Poisson model and the decayed, missing and filled teeth index in dental epidemiology

For frequency counts, the situation of extra zeros often arises in biomedical applications. This is demonstrated with count data from a dental epidemiological study in Belo Horizonte (the Belo Horizonte caries prevention study) which evaluated various programmes for reducing caries. Extra zeros, however, violate the variance–mean relationship of the Poisson error structure. This extra-Poisson variation can easily be explained by a special mixture model, the zero-inflated Poisson (ZIP) model. On the basis of the ZIP model, a graphical device is presented which not only summarizes the mixing distribution but also provides visual information about the overall mean. This device can be exploited to evaluate and compare various groups. Ways are discussed to include covariates and to develop an extension of the conventional Poisson regression. Finally, a method to evaluate intervention effects on the basis of the ZIP regression model is described and applied to the data of the Belo Horizonte caries prevention study.     

Between stability and higher-order asymptotics

We discuss the effects of model misspecifications on higher-order asymptotic approximations of the distribution of estimators and test statistics. In particular we show that small deviations from the model can wipe out the nominal improvements of the accuracy obtained at the model by second-order approximations of the distribution of classical statistics. Although there is no guarantee that the first-order robustness properties of robust estimators and tests will carry over to second-order in a neighbourhood of the model, the behaviour of robust procedures in terms of second-order accuracy is generally more stable and reliable than that of their classical counterparts. Finally, we discuss some related work on robust adjustments of the profile likelihood and outline the role of computer algebra in this type of research.     

Bayesian influence diagnostics in radiocarbon dating

Linear models constitute the primary statistical technique for any experimental science. A major topic in this area is the detection of influential subsets of data, that is, of observations that are influential in terms of their effect on the estimation of parameters in linear regression or of the total population parameters. Numerous studies exist on radiocarbon dating which propose a value consensus and remove possible outliers after the corresponding testing. An influence analysis for the value consensus from a Bayesian perspective is developed in this article.     

Lower posterior death probabilities from a quick medical response in road traffic accidents

Introduction: We use data from Spain on roads and motorways traffic accidents in May 2004 to quantify the statistical association between quick medical response time and mortality rate. Method: Probit and logit parameters are estimated by a Bayesian method in which samples from the posterior densities are obtained through an MCMC simulation scheme. We provide posterior credible intervals and posterior partial effects of a quick medical response at several time levels over which we express our prior beliefs. Results: A reduction of 5 min, from a 25-min response-time level, is associated with lower posterior probabilities of death in roads and motorways accidents of 24% and 30%, respectively.     

Hypothesis test for paired samples in the presence of missing data

Missing data are present in almost all statistical analysis. In simple paired design tests, when some subject has one of the involved variables missing in the so-called partially overlapping samples scheme, it is usually discarded for the analysis. The lack of consistency between the information reported in the univariate and multivariate analysis is, perhaps, the main consequence. Although the randomness on the missing mechanism (missingness completely at random) is an usual and needed assumption for this particular situation, missing data presence could lead to serious inconsistencies on the reported conclusions. In this paper, the authors develop a simple and direct procedure which allows using the whole available information in order to perform paired tests. In particular, the proposed methodology is applied to check the equality among the means from two paired samples. In addition, the use of two different resampling techniques is also explored. Finally, real-world data are analysed.     

Estimating utility functions using generalized maximum entropy

This paper estimates von Neumann and Morgenstern utility functions using the generalized maximum entropy (GME), applied to data obtained by utility elicitation methods. Given the statistical advantages of this approach, we provide a comparison of the performance of the GME estimator with ordinary least square (OLS) in a real data small sample setup. The results confirm the ones obtained for small samples through Monte Carlo simulations. The difference between the two estimators is small and it decreases as the width of the parameter support vector increases. Moreover, the GME estimator is more precise than the OLS one. Overall, the results suggest that GME is an interesting alternative to OLS in the estimation of utility functions when data are generated by utility elicitation methods.     

Bayesian factor models in characterizing molecular adaptation

Assessing the selective influence of amino acid properties is important in understanding evolution at the molecular level. A collection of methods and models has been developed in recent years to determine if amino acid sites in a given DNA sequence alignment display substitutions that are altering or conserving a prespecified set of amino acid properties. Residues showing an elevated number of substitutions that favorably alter a physicochemical property are considered targets of positive natural selection. Such approaches usually perform independent analyses for each amino acid property under consideration, without taking into account the fact that some of the properties may be highly correlated. We propose a Bayesian hierarchical regression model with latent factor structure that allows us to determine which sites display substitutions that conserve or radically change a set of amino acid properties, while accounting for the correlation structure that may be present across such properties. We illustrate our approach by analyzing simulated data sets and an alignment of lysin sperm DNA.     

Causality and interdependence analysis in linear econometric models with an application to fertility

This paper is an applied analysis of the causal structure of linear multi-equational econometric models. Its aim is to identify the kind of relationships linking the endogenous variables of the model, distinguishing between causal links and feedback loops. The investigation is first carried out within a deterministic framework and then moves on to show how the results may change inside a more realistic stochastic context. The causal analysis is then specifically applied to a linear simultaneous equation model explaining fertility rates. The analysis is carried out by means of a specific RATS programming code designed to show the specific nature of the relationships within the model.     

Block and Basu bivariate lifetime distribution in the presence of cure fraction

This paper presents estimates for the parameters included in the Block and Basu bivariate lifetime distributions in the presence of covariates and cure fraction, applied to analyze survival data when some individuals may never experience the event of interest and two lifetimes are associated with each unit. A Bayesian procedure is used to get point and confidence intervals for the unknown parameters. Posterior summaries of interest are obtained using standard Markov Chain Monte Carlo methods in rjags package for R software. An illustration of the proposed methodology is given for a Diabetic Retinopathy Study data set.