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Parental influence on friendships between native (= 5,683) and immigrant (= 3,371) adolescents (aged ± 15) was investigated with the CILS4EU data of pupils in German and Dutch school classes (= 446) and parents. The researchers examined whether parents affect friendships across group boundaries by shaping the structural opportunities to establish out‐group friends and their children's out‐group attitudes. The results show that if parents have more out‐group friends and if they consider it less important to maintain in‐group traditions, their children have more out‐group friends. Part of this relationship is mediated by children's out‐group attitudes. Some evidence is found that the opportunity structure mediates the relationship between parental characteristics and adolescent out‐group friendship.  相似文献   
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Many oncology studies incorporate a blinded independent central review (BICR) to make an assessment of the integrity of the primary endpoint, progression free survival. Recently, it has been suggested that, in order to assess the potential for bias amongst investigators, a BICR amongst only a sample of patients could be performed; if evidence of bias is detected, according to a predefined threshold, the BICR is then assessed in all patients, otherwise, it is concluded that the sample was sufficient to rule out meaningful levels of bias. In this paper, we present an approach that adapts a method originally created for defining futility bounds in group sequential designs. The hazard ratio ratio, the ratio of the hazard ratio (HR) for the treatment effect estimated from the BICR to the corresponding HR for the investigator assessments, is used as the metric to define bias. The approach is simple to implement and ensures a high probability that a substantial true bias will be detected. In the absence of bias, there is a high probability of accepting the accuracy of local evaluations based on the sample, in which case an expensive BICR of all patients is avoided. The properties of the approach are demonstrated by retrospective application to a completed Phase III trial in colorectal cancer. The same approach could easily be adapted for other disease settings, and for test statistics other than the hazard ratio. Copyright © 2015 John Wiley & Sons, Ltd.  相似文献   
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Over the previous seven years the application of a social generation paradigm or ‘theory’ has gained increasing currency as a method in analysing young people's relationship with the life course. Whilst not a new concept or approach its resurgence and reconfiguration to ‘new’ times has seen some writers positioning it as a ‘new orthodoxy’ or ‘consensus’ within youth studies. In this it is seen as providing a conceptual framework that better helps us understand the complexity of circumstances and conditions that shape youth identities in late modern society. In this paper we examine and explore the underlying assumptions and claims that are made by those advocating the social generational paradigm, raising questions and seeking further clarification on a number of key themes. We accept youth studies needs to move beyond ‘old models’ that define and understand social context as a simply a tension between ‘structure or/and agency’ or as a ‘flavour’ to social action. To conclude therefore we propose the need to have an approach that is ecological and both accepts ‘social change’ and ‘continuity’ as critical parts of the life course, one that recognises the nature and influence of power and social reproduction, especially for different social classes, in shaping the experience of being young.  相似文献   
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This article represents an effort to formulate an ethical framework for long-term care with the explicit purpose of providing a catalyst to promote further discourse and expand consideration of what an ethic of long-term care might entail. Grounding the discussion, an introduction to traditional ethical philosophy is presented, focusing mainly on the fundamentals of deontological and teleological ethical theories. Attention then shifts to a review of the more frequently cited principles found in the long-term care ethics literature, followed by a critique of the current reliance upon principlism to resolve ethical dilemmas in long-term care. In response to this criticism, an agent-driven ethical framework stressing dignity and respect for personhood, drawn from the philosophy of Immanuel Kant, is advanced.  相似文献   
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In the June issue ofSociological Forum, several authors addressed the question, What's Wrong with Sociology. Answers included increased fragmentation of the discipline, and the lack of an identifiable cumulative core of sociological knowledge. This paper examines many of the claims made by the contributors to the June 1994Sociological Forum, reframes their arguments, and by placing debates regarding the problems in sociology in a broader perspective, identifies many of the recent advances made by the discipline. Focusing on such notable contributions to the field as feminist and postmodern scholarship, we locate the positive side of multiple perspective research.Feminist Scholars in Sociology is a collective of researchers and teachers at the University of Colorado interested in exploring and sharing feminist theory and methodology.  相似文献   
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