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51.
Noninferiority trials intend to show that a new treatment is ‘not worse'' than a standard-of-care active control and can be used as an alternative when it is likely to cause fewer side effects compared to the active control. In the case of time-to-event endpoints, existing methods of sample size calculation are done either assuming proportional hazards between the two study arms, or assuming exponentially distributed lifetimes. In scenarios where these assumptions are not true, there are few reliable methods for calculating the sample sizes for a time-to-event noninferiority trial. Additionally, the choice of the non-inferiority margin is obtained either from a meta-analysis of prior studies, or strongly justifiable ‘expert opinion'', or from a ‘well conducted'' definitive large-sample study. Thus, when historical data do not support the traditional assumptions, it would not be appropriate to use these methods to design a noninferiority trial. For such scenarios, an alternate method of sample size calculation based on the assumption of Proportional Time is proposed. This method utilizes the generalized gamma ratio distribution to perform the sample size calculations. A practical example is discussed, followed by insights on choice of the non-inferiority margin, and the indirect testing of superiority of treatment compared to placebo.KEYWORDS: Generalized gamma, noninferiority, non-proportional hazards, proportional time, relative time, sample size 相似文献
52.
Max Weber (1864–1920) is considered one of the canonical founders of sociology, while W. E. B. Du Bois (1868–1963), author of The Philadelphia Negro (1899), The Souls of Black Folk (1903), and Black Reconstruction (1935), has only recently been included in the sociological canon. We provide a historical review of what we know of their relationship in order to first ask, what did Du Bois say about Weber, and second, what did Weber say about Du Bois? We then analyze the extant scholarly discourse of published English-language academic journal articles that substantively mention both Weber and Du Bois in order to address a third question: what did other scholars say about their relationship? We provide an analysis of the variation of scholars’ perceptions on the relationship between Du Bois and Weber to illumine the dominant assumptions about founding figures and the origin story of American sociology writ large. We argue that three mechanisms of white group interests configured the marginalization of Du Bois from both mainstream and sub-disciplinary sociological theory: (1) reduction or “knowing that we do no know and not caring to know” (when knowledge is perceived as irrelevant to white group interests), (2) deportation or “not wanting to know” (when knowledge is systematically exiled), and (3) appropriation or “not knowing that we do not know”) (when dominant knowledge usurps or assimilates challenges to that knowledge). 相似文献
53.
54.
Gemma Sicouri Lucy Tully Daniel Collins Matthew Burn Kristina Sargeant Paul Frick Vicki Anderson David Hawes Eva Kimonis Caroline Moul Roshel Lenroot Mark Dadds 《Australian and New Zealand Journal of Family Therapy》2018,39(2):218-231
Levels of father participation in parenting interventions are often very low, yet little is known about the factors which influence father engagement. We aimed to qualitatively explore perceived barriers to, and preferences for, parenting interventions in a community sample of fathers. Forty‐one fathers across nine focus groups were interviewed using a semi‐structured interview. Data were analysed using inductive thematic analysis. Key barriers to father participation identified included: the perception that interventions are mother‐focused; beliefs about gender roles regarding parenting and help‐seeking; mothers’ role as ‘gatekeeper’; lack of knowledge and awareness of parenting interventions; and lack of relevance of interventions. Fathers reported preferences for specific content and intervention features, facilitator characteristics, practical factors, and highlighted the need for father‐targeted recruitment and advertising. Many of the barriers and preferences identified are consistent with previous research; however, fathers’ beliefs and attitudes around gender roles and help‐seeking, as well as the perception that interventions are predominantly mother‐focused, may be key barriers for community fathers. Strategies to overcome these barriers and better meet the needs of fathers in promoting and delivering parenting interventions are discussed. 相似文献
55.
Matthew J. Slater Martin J. Turner Andrew L. Evans Marc V. Jones 《The Leadership Quarterly》2018,29(3):379-388
The influence of relational identification (RI) on leadership processes and the effects of social identity leadership on followers' responses to stress have received scant theoretical and research attention. The present research advances theoretical understanding by testing the assertion that high RI with the leader drives follower mobilization of effort and psychophysiological responses to stress. Two experimental scenario studies (Study 1 and Study 2) support the hypothesis that being led by an individual with whom followers perceive high RI increases follower intentional mobilization. Study 2 additionally showed that high (vs. low) RI increases follower resource appraisals and cognitive task performance. A laboratory experiment (Study 3) assessing cardiovascular (CV) reactivity showed that, compared to neutral (i.e., non-affiliated) leadership, being led by an individual with whom participants felt low RI elicited a maladaptive (i.e., threat) response to a pressurized task. In addition, relative to the low RI and neutral conditions, high RI with the leader did not engender greater challenge or threat reactivity. In conclusion, advancing social identity leadership and challenge and threat theory, findings suggest that leaders should be mindful of the deleterious effects (i.e., reduced mobilization and greater threat state) of low RI to optimize follower mobilization of effort and psychophysiological responses to stress. 相似文献
56.
Francisco J. Aragón Artacho Rubén Campoy Ilias Kotsireas Matthew K. Tam 《Journal of Combinatorial Optimization》2018,35(4):1061-1085
In this work, we propose an optimization approach for constructing various classes of circulant combinatorial designs that can be defined in terms of autocorrelation. The problem is formulated as a so-called feasibility problem having three sets, to which the Douglas–Rachford projection algorithm is applied. The approach is illustrated on three different classes of circulant combinatorial designs: circulant weighing matrices, D-optimal matrices of circulant type, and Hadamard matrices with two circulant cores. Furthermore, we explicitly construct two new circulant weighing matrices, a CW(126, 64) and a CW(198, 100), whose existence was previously marked as unresolved in the most recent version of Strassler’s table. 相似文献
57.
In this article, we examine birth cohort differences in parents’ provision of monetary help to adult children with particular focus on the extent to which cohort differences in family structure and the transition to adulthood influence these changes. Using data from the Health and Retirement Study from 1994 to 2010, we compare financial help to children of three respondent cohorts as the parents in these birth cohorts from ages 53–58 to 57–62. We find that transfers to children have increased among more recent cohorts. Two trends—declining family size and children’s delay in marriage—account for part of the increase across cohorts. However, other trends, such as the increase in the number of stepchildren and increasing child’s income level, tend to decrease the observed cohort trend. 相似文献
58.
We find that Union Army veterans of the American Civil War who faced greater wartime stress (as measured by higher battlefield
mortality rates) experienced higher mortality rates at older ages, but that men who were from more cohesive companies were
statistically significantly less likely to be affected by wartime stress. Our results hold for overall mortality, mortality
from ischemic heart disease and stroke, and new diagnoses of arteriosclerosis. Our findings represent one of the first long-run
health follow-ups of the interaction between stress and social networks in a human population in which both stress and social
networks are arguably exogenous. 相似文献
59.
The Pacific Sociological Association annual meeting recently added a new session type called the Research-in-Progress (RIP) session. The purpose of adding these sessions was to provide an opportunity for attendees to present research still in formative stages of completion in order to get useful feedback. Presentations ranged from doctoral dissertation proposals to nearly completed research. Early experience from RIP session organizers and discussants is that these sessions were lively and engaging, sparking a great deal of audience participation. Feedback from presenters indicated that they received useful feedback. Based on our initial experience with the RIP sessions, we believe they are a beneficial addition to the meetings. 相似文献
60.
M Watson 《The British journal of sociology》2012,63(3):491-512
Adam Smith and Thorstein Veblen shared much in matters of economic ontology. Both dismissed the very notion of an autonomous economic self and instead investigated the processes through which self and other are mutually constituted under changing cultural traditions of individual aspiration. Their strikingly similar critiques of status-oriented consumption and concern for the moral basis of the market economy are established in this manner. However, the political implications of their analyses point in different directions, with Veblen being the more radical. The Smithian individual can always use spectatorial insights to assert through genuinely praiseworthy behaviour personal moral distance from social norms of status-oriented consumption. The Veblenian individual, by contrast, has no such capacity for elevating abstract moral principles above socially-situated conduct, as mind and environment co-evolve in line with changing material circumstances of life. For Veblen, the rise of status-oriented consumption itself acted as a form of moral self-education that more deeply entrenched the social norms of ownership out of which it arose, thus the impossibility of an autonomous economic self was matched by the impossibility of an autonomous moral self. To his way of thinking, moral degradation in conspicuous consumption was irredeemably inscribed into the whole cultural structure of capitalism. 相似文献