Does the road to muscle rejuvenation go through Notch?

The capacity of skeletal muscles to repair and regenerate declines during aging in humans, and this decline may lead to muscle loss and frailty. Conboy et al. show that injured muscles of aging mice are defective in Notch signaling, because up-regulation of the Notch ligand, Delta-1, is impaired. Delta-1 promotes proliferation of the satellite cells that repair damaged muscles, and Conboy et al. show that experimental activation of Notch signaling is sufficient to reverse the age-related decline in muscle regenerative capacity. Extension of these important findings to humans could lead to the development of new therapeutic approaches to maintain muscle function during aging.     

Outbreaks of acute gastroenteritis associated with Norwalk-like viruses in campus settings

Norwalk-like viruses (NLVs) are transmitted by fecally contaminated food, water, fomites, and person-to-person contact. They are a leading cause of acute gastroenteritis epidemics in industrialized countries. NLV outbreaks are characterized by a 12- to 48-hour incubation period; nausea, vomiting, and diarrhea for 24 to 72 hours; and high secondary attack rates. NLV infections spread rapidly on college and university campuses because of close living quarters, shared bathrooms and common rooms, many food handlers, popular self-service salad bars in dining halls, and person-to-person contact through sports and recreational activities. The illness is generally mild and self-limited but an outbreak can strain the resources of campus health services and cause high absenteeism among both students and staff. Treatment is primarily through antiemetic medication and oral rehydration. Prevention and control of NLV outbreaks rests on promoting hand washing; enforcement of strict hygiene in all food preparation areas; and prompt, rigorous cleaning of potentially contaminated areas where someone has been ill.     

Functional testing: Approaches and injury management integration

Functional Capacity Evaluations (FCEs) have become the standard for identifying an individual's physical abilities and/or limitations following injury or illness. While philosophies and approaches differ, the focus of most FCE systems is to identify the individual's maximum capabilities. This article will discuss the usefulness of the FCE information and how FCEs are impacted by multiple factors including APTA guidelines, machine based testing, therapist expertise, medical legal credibility and court testimony, IMEs and FCE, and return to work/return to function.     

Technology and managing people:

conclusion The Information Age has revolutionized the workplace. While it is possible to purchase or copy machines and technology, their very interchangeability means they fail to cre-ate a sustained competitive advantage for an organization (Barney, 1991). The research directions this paper offers are intended to develop firm knowledge that allows creation of inimitable human resources. Importantly, in the rush to embrace new information technologies, organizations must remember the fundamental principle that workers will invest in firm goals in the presence of shared values and a commitment by the firm to make their well-being a priority. We urge continued attention to fulfillment of the psy-chological contract, and to the "people issues" that frequently seem less critical than issues of hardware or technology.     

Introduction: “There Is a Person Here”: An Interview with Judith Butler

In this interview, the coeditors, along with other contributors, ask Judith Butler a variety of questions regarding queer theory, gender identities, scientific and legal discourse, bodily abjection, race and class positioning, and political organizing. This range of subject matter suggests not only the breadth of Butler's work, but also its applicability to any number of people, whose relation to theory ranges from highly politicized to politically indifferent. The interview demonstrates the responsiveness of Butler's work to cultural translation and political action.     

THE PROCESS OF CHANGE IN COUPLES THERAPY: A QUALITATIVE INVESTIGATION

Open-ended interviews with 24 couples therapy clients regarding their experience of the process of change revealed shifts in clusters of affect, communication, and cognition. Six additional contextual preconditions for change were also identified. The change process within couples was uniformly reported to be gradual.     

The nature of living systems

Living systems theory (LST) is concerned with eight levels of living systems, each of which is composed of 20 critical subsystems that carry out essential life processes. As a result of a continuous biosocial evolution involving progressive fray-out of components, the more recently developed levels in this hierarchy have become very complex. A brief summary of LST is presented in this article. Following this is a detailed analysis of current knowledge about the timer, which we have recently included in our list of subsystems.     

Reclaiming the Mother-daughter Relationship after Sexual Abuse

This paper seeks to provide direction to therapists working with mothers and daughters after a disclosure of father-daughter sexual abuse. The importance of the mother's belief in and support for the child's recovery is highlighted, as are some of the cultural assumptions about mothers and daughters which negatively impact on the relationship. Despite paying lip service to offender responsibility, there continues to be a culture of mother blaming in the child sexual abuse and family therapy literature on incest. Current research findings challenge some of the prevalent myths about mothers’ responses to their children's disclosures. Few clinical sources have addressed this issue, and therapists who reject the mother blaming literature are therefore left with little guidance as to how to work more effectively with mothers and daughters. Consequently they may unwittingly further undermine the relationship. Work with mothers and daughters as they recover from intrafamilial sexual abuse is discussed, and key therapeutic themes and guidelines for practice presented. We explore the significant theme of the rebuilding of trust between mothers and daughters and facilitate a process whereby the woman is able to bear witness to and acknowledge the trauma experienced by her daughter.