A note on statistical method for genotype calling of high-throughput single-nucleotide polymorphism arrays

We study the genotype calling algorithms for the high-throughput single-nucleotide polymorphism (SNP) arrays. Building upon the novel SNP-robust multi-chip average preprocessing approach and the state-of-the-art corrected robust linear model with Mahalanobis distance (CRLMM) approach for genotype calling, we propose a simple modification to better model and combine the information across multiple SNPs with empirical Bayes modeling, which could often significantly improve the genotype calling of CRLMM. Through applications to the HapMap Trio data set and a non-HapMap test set of high quality SNP chips, we illustrate the competitive performance of the proposed method.     

知识共享对供应链信用风险传染的影响研究

将企业间知识共享这一因素引入供应链上下游企业博弈过程,在完全信息条件下研究三级供应链中零售商分别与分销商、制造商进行知识共享时知识共享量与企业信用风险水平和供应链信用风险传染强度之间的关系,并结合算例进行了数值分析.基于Stackelberg博弈模型的研究结果表明,供应链上的知识共享有助于降低供应链成员企业的信用风险;进行知识共享的企业间信用风险传染强度随着知识共享量的增加而增大;企业进行知识共享比不进行知识共享时受到其它企业信用风险传染的影响大.     

网络舆论倾向性的动态跟踪方法及实证研究

从统计学视角审视网络舆论倾向性的监测问题,提出了以粗糙分类器为基础建立舆论倾向性分类模型,将复杂的预警指标体系简化为单一直观的跟踪统计量,并通过跟踪统计量动态跟踪舆论倾向性变化轨迹的研究方法。实证研究以2011年郭美美事件相关新闻跟帖为对象。分析表明,网络舆论的消极倾向性在整个事件发展过程中呈持续增长,与基本事实相符,证实了方法的可行性和适用性。     

Semiparametric inference on the absolute risk reduction and the restricted mean survival difference

For time-to-event data, when the hazards are non-proportional, in addition to the hazard ratio, the absolute risk reduction and the restricted mean survival difference can be used to describe the time-dependent treatment effect. The absolute risk reduction measures the direct impact of the treatment on event rate or survival, and the restricted mean survival difference provides a way to evaluate the cumulative treatment effect. However, in the literature, available methods are limited for flexibly estimating these measures and making inference on them. In this article, point estimates, pointwise confidence intervals and simultaneous confidence bands of the absolute risk reduction and the restricted mean survival difference are established under a semiparametric model that can be used in a sufficiently wide range of applications. These methods are motivated by and illustrated for data from the Women’s Health Initiative estrogen plus progestin clinical trial.     

Generation of multivariate distributions by vertical density representation

Troutt (1991,1993) proposed the idea of the vertical density representation (VDR) based on Box-Millar method. Kotz, Fang and Liang (1997) provided a systematic study on the multivariate vertical density representation (MVDR). Suppose that we want to generate a random vector X[d]Rⁿthat has a density function ?(x). The key point of using the MVDR is to generate the uniform distribution on [D]_?(v) = {x :?(x) = v} for any v > 0 which is the surface in RⁿIn this paper we use the conditional distribution method to generate the uniform distribution on a domain or on some surface and based on it we proposed an alternative version of the MVDR(type 2 MVDR), by which one can transfer the problem of generating a random vector X with given density f to one of generating (X, X_n+i) that follows the uniform distribution on a region in Rⁿ⁺¹defined by ?. Several examples indicate that the proposed method is quite practical.     

Statistical inference on asymptotic properties of two estimators for the partially linear single-index models

The outer product of gradients (OPG) estimation procedure based on least squares (LS) approach has been presented by Xia et al. [An adaptive estimation of dimension reduction space. J Roy Statist Soc Ser B. 2002;64:363–410] to estimate the single-index parameter in partially linear single-index models (PLSIM). However, its asymptotic property has not been established yet and the efficiency of LS-based method can be significantly affected by outliers and heavy-tailed distributions. In this paper, we firstly derive the asymptotic property of OPG estimator developed by Xia et al. [An adaptive estimation of dimension reduction space. J Roy Statist Soc Ser B. 2002;64:363–410] in theory, and a novel robust estimation procedure combining the ideas of OPG and local rank (LR) inference is further developed for PLSIM along with its theoretical property. Then, we theoretically derive the asymptotic relative efficiency (ARE) of the proposed LR-based procedure with respect to LS-based method, which is shown to possess an expression that is closely related to that of the signed-rank Wilcoxon test in comparison with the t-test. Moreover, we demonstrate that the new proposed estimator has a great efficiency gain across a wide spectrum of non-normal error distributions and almost not lose any efficiency for the normal error. Even in the worst case scenarios, the ARE owns a lower bound equalling to 0.864 for estimating the single-index parameter and a lower bound being 0.8896 for estimating the nonparametric function respectively, versus the LS-based estimators. Finally, some Monte Carlo simulations and a real data analysis are conducted to illustrate the finite sample performance of the estimators.     

Variable Selection for Partially Linear Models with Randomly Censored Data

This article proposes a variable selection procedure for partially linear models with right-censored data via penalized least squares. We apply the SCAD penalty to select significant variables and estimate unknown parameters simultaneously. The sampling properties for the proposed procedure are investigated. The rate of convergence and the asymptotic normality of the proposed estimators are established. Furthermore, the SCAD-penalized estimators of the nonzero coefficients are shown to have the asymptotic oracle property. In addition, an iterative algorithm is proposed to find the solution of the penalized least squares. Simulation studies are conducted to examine the finite sample performance of the proposed method.     

On the Preliminary Test Backfitting and Speckman Estimators in Partially Linear Models and Numerical Comparisons

Przystalski and Krajewski (2007 Przystalski , M. , Krajewski , P. ( 2007 ). Constrained estimators of treatment parameters in semiparametric models . Statist. Probab. Lett. 77 : 914 – 919 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed the restricted backfitting (RBCF) estimator and restricted Speckman (RSPC) estimator for the treatment effects in a partially linear model when some additional exact linear restrictions are assumed to hold. In this article, we introduce the preliminary test backfitting (PTBCF) estimator and preliminary test Speckman (PTSPC) estimator when the validity of the restrictions is suspected. Performances of the proposed estimators are examined with respect to the mean squared error (MSE) criterion. In addition, numerical behaviors of the proposed estimators are illustrated and compared via a Monte Carlo simulation study.     

Using regression mixture models with non-normal data: examining an ordered polytomous approach

Mild to moderate skew in errors can substantially impact regression mixture model results; one approach for overcoming this includes transforming the outcome into an ordered categorical variable and using a polytomous regression mixture model. This is effective for retaining differential effects in the population; however, bias in parameter estimates and model fit warrant further examination of this approach at higher levels of skew. The current study used Monte Carlo simulations; 3000 observations were drawn from each of two subpopulations differing in the effect of X on Y. Five hundred simulations were performed in each of the 10 scenarios varying in levels of skew in one or both classes. Model comparison criteria supported the accurate two-class model, preserving the differential effects, while parameter estimates were notably biased. The appropriate number of effects can be captured with this approach but we suggest caution when interpreting the magnitude of the effects.     

Generalized Quasi-Regression

Quasi-regression, an approach for approximating an unknown function on the unit cube in very high dimensions, has very high computational efficiency. In this article, generalized quasi-regression is introduced. Some theoretical results on the generalized quasi-regression are provided, and numerical examples are illustrated.