A Bayesian adaptive design for two-stage clinical trials with survival data

A randomized two-stage adaptive Bayesian design is proposed and studied for allocation and comparison in a phase III clinical trial with survival time as treatment response. Several exact and limiting properties of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with a single-stage randomized procedure. The applicability of the proposed methodology is illustrated by using some real data.     

On confidence intervals associated with the usual and adjusted likelihoods

In the presence of nuisance parameters, we drive an explicit higher order asymptotic formula to compare the expected lengths of confidence intervals given by likelihood ratio statistics arising from the usual profile likelihood and various adjustments thereof. Highest posterior density regions, with approximate frequentist validity, are also included in the study.     

Interval estimation of the population mean under model uncertainty: Robust versus empirical statistics

With reference to the problem of interval estimation of a population mean under model uncertainty, we compare approaches based on robust and empirical statistics via expected lengths of the associated confidence intervals. An explicit expression for confidence intervals arising from a general class of robust statistics is worked out and this is employed to obtain a higher order asymptotic formula for the expected lengths of such intervals. Comparative theoretical results, as well as a simulation study, are then presented.     

Regression Type Estimators Using Multiple Auxiliary Information

In this paper we consider a practical situation where information on two auxiliary variables related to the study variable is available at different levels. Following Kiregyera (1980, 1984) who has obtained a chain ratio-to-regression estimator and regression to regression estimator, we shall study several estimators that arise naturally in this context and compare them under the mean square error criterion. We extend these results to the case when multiple auxiliary information is available.     

A New Test for New Better Than Used in Expectation Lifetimes

The mean residual life of a non negative random variable X with a finite mean is defined by M(t) = E[X ? t|X > t] for t ? 0. A popular nonparametric model of aging is new better than used in expectation (NBUE), when M(t) ? M(0) for all t ? 0. The exponential distribution lies at the boundary. There is a large literature on testing exponentiality against NBUE alternatives. However, comparisons of tests have been made only for alternatives much stronger than NBUE. We show that a new Kolmogorov-Smirnov type test is much more powerful than its competitors in most cases.     

Matrix completion with nonconvex regularization: spectral operators and scalable algorithms

Statistics and Computing - In this paper, we study the popularly dubbed matrix completion problem, where the task is to “fill in” the unobserved entries of a matrix from a small subset...     

The Limited Role of Formal Statistical Inference in Scientific Inference

ABSTRACT

Such is the grip of formal methods of statistical inference—that is, frequentist methods for generalizing from sample to population in enumerative studies—in the drawing of scientific inferences that the two are routinely deemed equivalent in the social, management, and biomedical sciences. This, despite the fact that legitimate employment of said methods is difficult to implement on practical grounds alone. But supposing the adoption of these procedures were simple does not get us far; crucially, methods of formal statistical inference are ill-suited to the analysis of much scientific data. Even findings from the claimed gold standard for examination by the latter, randomized controlled trials, can be problematic.

Scientific inference is a far broader concept than statistical inference. Its authority derives from the accumulation, over an extensive period of time, of both theoretical and empirical knowledge that has won the (provisional) acceptance of the scholarly community. A major focus of scientific inference can be viewed as the pursuit of significant sameness, meaning replicable and empirically generalizable results among phenomena. Regrettably, the obsession with users of statistical inference to report significant differences in data sets actively thwarts cumulative knowledge development.

The manifold problems surrounding the implementation and usefulness of formal methods of statistical inference in advancing science do not speak well of much teaching in methods/statistics classes. Serious reflection on statistics' role in producing viable knowledge is needed. Commendably, the American Statistical Association is committed to addressing this challenge, as further witnessed in this special online, open access issue of The American Statistician.     

Algorithmic and analytical construction of efficient designs in small blocks for comparing consecutive pairs of treatments

Optimal block designs in small blocks are explored under the A-, E- and D-criteria when the treatments have a natural ordering and interest lies in comparing consecutive pairs of treatments. We first formulate the problem via approximate theory which leads to a convenient multiplicative algorithm for obtaining A-optimal design measures. This, in turn, yields highly efficient exact designs, under the A-criterion, even when the number of blocks is rather small. Moreover, our approach is seen to allow nesting of such efficient exact designs which is an advantage when the resources for the experiment are available in possibly several stages. Illustrative examples are given and tables of A-optimal design measures are provided. Approximate theory is also seen to yield analytical results on E- and D-optimal design measures.     

Perinatal issues for women with high functioning autism spectrum disorder

Problem

Autistic Spectrum Disorder (ASD) is an increasingly commonly diagnosed disability. People with ASD commonly report challenges in social interaction and a heightened sensory perception. These challenges may be particularly difficult for women during pregnancy, birthing and beyond.