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361.
In the development of many diseases there are often associated random variables which continuously reflect the progress of a subject towards the final expression of the disease (failure). At any given time these processes, which we call stochastic covariates, may provide information about the current hazard and the remaining time to failure. Likewise, in situations when the specific times of key prior events are not known, such as the time of onset of an occult tumour or the time of infection with HIV-1, it may be possible to identify a stochastic covariate which reveals, indirectly, when the event of interest occurred. The analysis of carcinogenicity trials which involve occult tumours is usually based on the time of death or sacrifice and an indicator of tumour presence for each animal in the experiment. However, the size of an occult tumour observed at the endpoint represents data concerning tumour development which may convey additional information concerning both the tumour incidence rate and the rate of death to which tumour-bearing animals are subject. We develop a stochastic model for tumour growth and suggest different ways in which the effect of this growth on the hazard of failure might be modelled. Using a combined model for tumour growth and additive competing risks of death, we show that if this tumour size information is used, assumptions concerning tumour lethality, the context of observation or multiple sacrifice times are no longer necessary in order to estimate the tumour incidence rate. Parametric estimation based on the method of maximum likelihood is outlined and is applied to simulated data from the combined model. The results of this limited study confirm that use of the stochastic covariate tumour size results in more precise estimation of the incidence rate for occult tumours.  相似文献   
362.
The usual test of the equality of two slopes in a simple structural relation-ship is the test formed from the normal approximation using the Fisher information matrix, assuming two explanatory variables are independent. This paper examines the robustness if the explanatory variables are, in fact, dependent. A more efficient estimator is derived for a matched pair situation.  相似文献   
363.
We consider estimation of the number of cells in a multinomial distribution. This is one version of the species problem: there are many applications, such as the estimation of the number of unobserved species of animals; estimation of vocabulary size, etc. We describe the results of a simulation comparison of three principal frequent-ist' procedures for estimating the number of cells (or species). The first procedure postulates a functional form for the cell probabilities; the second procedure approxi mates the distribution of the probabilities by a parametric probability density function; and the third procedure is based on an estimate of the sample coverage, i.e. the sum of the probabilities of the observed cells. Among the procedures studied, we find that the third (non-parametric) method is globally preferable; the second (functional parametric) method cannot be recommended; and that, when based on the inverse Gaussian density, the first method is competitive in some cases with the third method. We also discuss Sichel's recent generalized inverse Gaussian-based procedure which, with some refine ment, promises to perform at least as well as the non-parametric method in all cases.  相似文献   
364.
In this note we prove some inequalities for variances and other measures of deviation of functions of random variables. Based on these inequalities we find some corollaries concerning the variances of fractional powers of random variables and of sums of independent random variables.  相似文献   
365.
In a recent paper in this journal, Lee, Kapadia and Brock (1980) developed maximum likelihood (ML) methods for estimating the scale parameter of the Rayleigh distribution from doubly censored samples. They reported convergence difficulties in attempting to solve numerically the nonlinear likelihood equation (LE). To mitigate these difficulties, they employed approximations to simplify the LE, but found that the solution of the resulting simplified equation can give rise to parameter estimates of erratic accuracy. We show that the use of approximations to simplify the LE is unnecessary. In fact, under suitable parametric transformation, the log-likelihood function is strictly concave, the ML estimate always exists, is unique and finite. Furthermore, the LE is easy to solve numerically. A numerical example is given to illustrate the computations involved.  相似文献   
366.
Victims of spouse abuse were interviewed concerning their views of why their husbands were abusive. It was hypothesized that by concentrating on one specific characteristic of this kind previously undocumented patterns of response would be elicited from the subjects. It was concluded that the women's reasons for the violence perpetrated by their spouses serve as justification for the abusers’actions and legitimize maintenance of the relationship.  相似文献   
367.
Dental caries in children is now recognized as a preventable disease. The use of fluoride and sealants has produced a major reduction in caries prevalence among school aged children in the United States and other countries. A portion of the child population who are educationally and socioeconomically disadvantaged are not fully receiving these benefits. Public policy, insurance and medicaid groups must be made aware of these preventative measures and strategies developed to implement them.  相似文献   
368.
Using mail survey data based on a stratified systematic sample [N = 686] of 1983–1988 graduates of a medium-sized state university, this research evaluates whether ROTC program participation constitutes an independent source of human capital in civilian labor markets by comparing postgraduate earnings (annual income), prestige and authority, and life satisfaction of ROTC program participants with those of nonparticipants. The results revealed no statistically significant ROTC program participation effects, independent of subsequent military status. ROTC program participation paid off in terms of occupational prestige and authority for those on active duty, but not for those in national guard or reserve units. Neither ROTC participation nor current military status affected income or life satisfaction levels.  相似文献   
369.
This paper develops a Coase-like solution of the problem of inducing Pareto optimal behavior in the presence of reciprocal externalities. In place of Coasean direct compensation between the parties to an externality problem, actors strategically match each other's externality-producing activity, and thus induce counterparts to internalize the external benefits or costs of their actions. The analysis suggests a general framework for analyzing social interactions in the presence of reciprocal externalities. As an application of the theory, a solution of the duopoly problem is noted.We are indebted to L. Danziger, D. Samet, participants in faculty seminars at Bar-Ilan and New York Universities and at the University of Maryland, and two anonymous referees for helpful comments and discussions. All remaining errors are our own.  相似文献   
370.
In this paper we argue for the importance of a sociologically informed study of organizational accounting practices. By making the nexus between accounting and decision making problematic, instead of given, we move issues of interpretation and hierarchical control to the center stage of understanding the social construction of accounting practices. We suggest that inductive case studies of the organizational setting is a promising methodological strategy for identifying how accounting operates as an organizational control system. We focus on debates and proceedings of the board of directors as an overlooked source of data on decision making and organizational practices. We show how accounting practices are part of the strategic control system that functions to interpret the environment and direct the adaptation of the organization in a manner particular to the substantive rationality of corporate decision makers. We illustrate these contentions with a case study of accounting practice changes over a six year period.  相似文献   
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