Adaptive designs for IVPT data with mixed scaled average bioequivalence

In vitro permeation tests (IVPT) offer accurate and cost-effective development pathways for locally acting drugs, such as topical dermatological products. For assessment of bioequivalence, the FDA draft guidance on generic acyclovir 5% cream introduces a new experimental design, namely the single-dose, multiple-replicate per treatment group design, as IVPT pivotal study design. We examine the statistical properties of its hypothesis testing method—namely the mixed scaled average bioequivalence (MSABE). Meanwhile, some adaptive design features in clinical trials can help researchers make a decision earlier with fewer subjects or boost power, saving resources, while controlling the impact on family-wise error rate. Therefore, we incorporate MSABE in an adaptive design combining the group sequential design and sample size re-estimation. Simulation studies are conducted to study the passing rates of the proposed methods—both within and outside the average bioequivalence limits. We further consider modifications to the adaptive designs applied for IVPT BE trials, such as Bonferroni's adjustment and conditional power function. Finally, a case study with real data demonstrates the advantages of such adaptive methods.     

Welfare Reform and Elderly Immigrants' Health Insurance Coverage: The Roles of Federal and State Medicaid Eligibility Rules

Immigrants' access to federally-funded Medicaid became limited after welfare reform imposed restrictive noncitizen eligibility rules. This study used a representative sample from the Current Population Survey (N?=?105,873) and state-level data to examine the effects of these policy changes on elderly immigrants. Triple difference-in-differences analyses show that federal restriction of eligibility had a significantly negative association with elderly immigrants' Medicaid coverage, and generous state eligibility had significantly positive relationships with Medicaid and any health insurance coverage. Findings indicate the important role of eligibility on elderly immigrants' health insurance coverage. Results call for social workers' actions to expand elderly immigrants' Medicaid eligibility.     

The Development and Initial Psychometric Evaluation of the Korean Career Stress Inventory for College Students

The purpose of this study was to develop a Korean College Stress Inventory (KCSI), which is designed to measure Korean college students' experiences and symptoms of career stress. Even though there have been numerous scales related to career issues, few scales measure the career stress construct and its dimensions. Factor structure, internal consistency, and concurrent validity of the KCSI scores are described. Results indicated that the internal consistency reliabilities of 4 KCSI subscale scores were reasonably high. In addition, the exploratory and confirmatory factor analyses indicated that the modified 4‐factor solution seemed to provide a reasonably good fit to the data. Implications, limitations, and recommendations for future research are discussed.     

Impacts of child development accounts on parenting practices: evidence from a randomised statewide experiment

ABSTRACT

This study examines the impact of Child Development Accounts (CDAs) on parenting practices of mothers with young children in a statewide randomised experiment conducted in the United States. The experiment included 2704 primary caregivers of children born in Oklahoma during 2007: 1358 were randomly assigned to the treatment group and 1346 to the control group. Structural equation modelling suggests that the punitive-parenting score among treatment participants was .12 standard deviations smaller than that among control participants (p < . 05). Findings indicate that CDAs reduce punitive parenting, and may serve as an additional tool for positive parent–child interactions.     

Risk Communication in The Netherlands: The Monitored Introduction of the EC "Post-Seveso" Directive

Implementation of article 8.1 of the EC-"Seveso" Directive (82/501/EC) is now under way in many countries in Europe. In The Netherlands, the implementation of the Directive started with a carefully monitored introduction of active information provision at two sites (Dordrecht and Elst). This introduction was supported by a multidisciplinary research group. This group helped to develop the risk communication program and also played a role in the evaluation of the program. This paper describes these processes and their evaluation. We will focus on the design of the risk communication programs and the effects of the programs on knowledge and attitudes of the local target groups. This effort and its results clearly started an institutional learning process involving governmental bodies at several organizational levels (local, regional, and national), and industrial organizations (individual firms and organizations of industries). Monitoring the design, the implementation, and the effects of active information provision proves an effective means to gain experience with the implementation of the Seveso Directive and could help to facilitate further implementation.     

Insights on medical tourism: markets as networks and the role of strong ties

Despite a huge amount of speculation and expectation surrounding medical tourism, hard empirical evidence is only now beginning to emerge. This paper widens the focus of discussion by contrasting two country experiences (UK and Korea) which on the surface illustrate the diversity of medical tourism and little else. However, considered more comparatively, the accounts contribute toward wider, albeit tentative, theoretical understandings, and insights. The paper is drawn from two broad programs of empirical study conducted over three years in UK and Korea, respectively. The article is structured in three parts: first, a brief overview of policy, legislative, and accreditation frameworks that exist to govern medical tourist flows. Second, we present evidence around flows, demographics, treatment, and medical tourism for Korea and UK (both for supply and demand). Third, we examine conceptual and theoretical implications of this evidence. We argue that viewing medical tourism as a global market is problematic; some medical tourist markets are best viewed as networks with long-term exchange relationships; some specific areas of activity do function more strongly as price-related; decision making around medical tourism frequently involves a range of information and social networks (economic action as embedded social structure); and medical tourism is a function of globalization.     

Semiparametric methods in nonlinear time series analysis: a selective review

Time series analysis is a tremendous research area in statistics and econometrics. In a previous review, the author was able to break down up 15 key areas of research interest in time series analysis. Nonetheless, the aim of the review in this current paper is not to cover a wide range of somewhat unrelated topics on the subject, but the key strategy of the review in this paper is to begin with a core the ‘curse of dimensionality’ in nonparametric time series analysis, and explore further in a metaphorical domino-effect fashion into other closely related areas in semiparametric methods in nonlinear time series analysis.     

Efficient method for identification of cyclic trends in incidence

Various methods for estimating the parameters of the simple harmonic curve and corresponding statistics for testing the significance of the sinusoidal trend are investigated. The locally reasonable method is almost fully efficient when the size of the trend is very small; however, the maximum likelihood method is preferred generally, especially when the trend is not very small. The log likelihood ratio test is more powerful than the R test which is based on locally reasonable estimates. The efficient method and the log likelihood ratio or equivalent tests are the best statistical techniques for identifying the cyclical trend. Thus they are the methods of choice when adequate computing facilities are available.     

Households' Perceived Personal Risk and Responses in a Multihazard Environment

This study proposed and tested a multistage model of household response to three hazards—flood, hurricane, and toxic chemical release—in Harris County Texas. The model, which extends Lindell and Perry's (1992, 2004) Protective Action Decision Model, proposed a basic causal chain from hazard proximity through hazard experience and perceived personal risk to expectations of continued residence in the home and adoption of household hazard adjustments. Data from 321 households generally supported the model, but the mediating effects of hazard experience and perceived personal risk were partial rather than complete. In addition, the data suggested that four demographic variables—gender, age, income, and ethnicity—affect the basic causal chain at different points.     

Innovation in education: Technological economics

Technological change and innovation are vital parts of the economy. This paper concerns one particular attempt to study both the process of innovation itself and possible means of increasing its effectiveness: Technological Economics. Barriers to innovation, intellectual and organizational, are described from the experience at the University of Stirling.