From waterfall plots to spaghetti plots in early oncology clinical development

Waterfall plots are used to describe changes in tumor size observed in clinical studies. They are frequently used to illustrate the overall drug response in oncology clinical trials because of its simple representation of results. Unfortunately, this visual display suffers a number of limitations including (1) potential misguidance by masking the time dynamics of tumor size, (2) ambiguous labelling of the y‐axis, and (3) low data‐to‐ink ratio. We offer some alternatives to address these shortcomings and recommend moving away from waterfall plots to the benefit of plots showing the individual time profiles of sum of lesion diameters (according to RECIST). The spider plot presents the individual changes in tumor measurements over time relative to baseline tumor burden. Baseline tumor size is a well‐known confounding factor of drug effect which has to be accounted for when analyzing data in early clinical trials. While spider plots are conveniently correct for baseline tumor size, they cannot be presented in isolation. Indeed, percentage change from baseline has suboptimal statistical properties (including skewed distribution) and can be overly optimistic in favor of drug efficacy. We argued that plots of raw data (referred to as spaghetti plots) should always accompany spider plots to provide an equipoised illustration of the drug effect on lesion diameters.     

Canadian Fossil Capitalism,Corporate Strategy,and Post‐Carbon Futures

This study investigates the relationship between the carbon extractive sector in Canada and renewable energy development. Specifically, it examines the strategies employed by Canadian carbon‐capital firms to shape and control alternative energy and considers if we are witnessing signs of “transition capture” as some oil, gas, and coal firms invest in a gradual shift toward “climate capitalism.” I investigate first, investments by large Canada‐based fossil fuel companies in renewable energy and second, interlocking directorate relations between the fossil fuel sector and the renewables industry. Findings suggest the possibility of a long‐term strategic orientation toward a climate capitalist model of development by some carbon‐capital firms; however, this alignment remains highly tentative, with evidence pointing to an industry that is largely without plans for energy transition.     

Inequality of opportunity in the land of opportunities, 1968–2001

We measure inequality of opportunity for earnings acquisition in the U.S. between 1968 and 2001. Following recent theories of social justice, earnings determinants are divided into two parts: Circumstances, which are characteristics outside individual control and effort representing factors impacting earnings but under individuals’ responsibility. Equality of opportunity requires that inequality of circumstances must be corrected while differences of effort must remain unaltered. Circumstances are represented by parental education and occupation, ethnic origin, place of birth and age. Effort is modeled with schooling choices and labour supply decisions. Using the PSID from 1968 to 2001, we provide two alternative assessments of inequality of opportunity using counterfactual distributions. The statistical framework is semi-parametric and builds on duration models. Finally, we conclude that inequality of opportunity represents between 20 and 43% of earnings inequality, but decreases all over the period reaching around 18% in 2001.     

‘The status quo is not an option’: Community impacts of school closure in South Taranaki,New Zealand

This paper explores the impacts of proposed school closures on families in rural communities in the South Taranaki region of New Zealand. We situate this instance of educational restructuring in a critical policy context and present an account of its regional unfolding through drawing on local media coverage. We then interpret narratives gathered during an interview-based study of the proposed changes undertaken in 2003–2004. Our analysis highlights the impact of school closure for rural settlements in terms of affect as well as effects. More generally we reflect on the place of schools in the experience of place itself, as well as their contribution to social cohesion and the broadly defined health of a community.     

Care moves people: complex systems and futures signals supporting production and reflection of individual mobile utopias

ABSTRACT

Futures of mobility are a pressing concern for cities addressing sustainability and climate change challenges. As cities renew their mobility systems and launch efforts to meet these targets, new sensitive qualitative methodologies are needed. This article discusses a focused mobility diary experiment that was conducted in May 2017 in Turku, Finland and its subarea, with a small set of participants. The goal of this study was to gain insights into potential developments in the city’s mobility systems and practices. This article utilises a multidisciplinary complex systems approach describing how we used the concepts of futures signals and mobile utopias as tools when analysing some prefigurative patterns in individual mobility practices. A key outcome of this methodological experimentation was the interconnections made between two research traditions and a notion of the various ways care underlies, effects, and contours the mobility practices of people–in other words, people are moved by care. This article demonstrates how with the concepts of futures signals, and mobilised utopias, we can reach the important aspirational and prefigurative practices and motivations of people, which permit us to interpret potential futures in particular urban settings characterised by daily life activities.     

What makes articles highly cited?

We examined drivers of article citations using 776 articles that were published from 1990 to 2012 in a broad-based and high-impact social sciences journal, The Leadership Quarterly. These articles had 1191 unique authors having published and received in total (at the time of their most recent article published in our dataset) 16,817 articles and 284,777 citations, respectively. Our models explained 66.6% of the variance in citations and showed that quantitative, review, method, and theory articles were significantly more cited than were qualitative articles or agent-based simulations. As concerns quantitative articles, which constituted the majority of the sample, our model explained 80.3% of the variance in citations; some methods (e.g., use of SEM) and designs (e.g., meta-analysis), as well as theoretical approaches (e.g., use of transformational, charismatic, or visionary type-leadership theories) predicted higher article citations. Regarding statistical conclusion validity of quantitative articles, articles having endogeneity threats received significantly fewer citations than did those using a more robust design or an estimation procedure that ensured correct causal estimation. We make several general recommendations on how to improve research practice and article citations.     

Strategic CSR for innovation in SMEs: Does diversity matter?

Both corporate social responsibility and diversity influence firms' innovation, yet their relationship and links to innovation remain uncertain, especially among small to medium-sized enterprises. Relying on strategic and institutional CSR perspectives and a value-in-diversity approach, this study examines the mediating roles of gender and nationality diversity on the CSR–innovation link at the organizational level. With a sample of 1348 SMEs from Luxembourg, the results show that strategic CSR can promote both types of diversity, but only nationality diversity triggers technological innovation. Nationality diversity emerges as a partial mediator of the relationship between CSR and SMEs’ technological innovation. Thus, strategic CSR, through the genuine pursuit of such diversity, can help SMEs attain positive returns on their product or process innovation. These results have important theoretical and managerial implications.     

Positive and negative preferences in human mate selection

This paper focuses on preferences for specific characteristics in a potential partner using data from 1993 to 1999 provided by a French marriage bureau. We perform an econometric analysis of the various traits either sought or rejected in a potential partner, respectively by men and women. Our results are consistent with investment in marriage. On the one hand, men tend to reject vulgar and unfaithful women, meaning that they are likely to suffer serious fitness costs from infidelity. On the other hand, women dread meeting potential partners who are alcoholic, selfish or violent.     

DEMOCRATIC PEACE AND ELECTORAL ACCOUNTABILITY

Democracies rarely engage in conflicts with one another, though they are not averse to fighting autocracies. We exploit the existence in many countries of executive term limits to show that electoral accountability is the key reason behind this “democratic peace” phenomenon. We construct a new dataset of term limits for a sample of 177 countries over the 1816–2001 period, and combine this information with a large dataset of interstate conflicts. Our empirical analysis shows that, although democracies are significantly less likely to fight each other, democracies with leaders who face binding term limits are as conflict prone as autocracies. The study of electoral calendars confirms the importance of re‐election incentives: in democracies with two‐term limits, conflicts are less likely to occur during the executive's first mandate than in the last one. Our findings support the Kantian idea that elections act as a discipline device, deterring leaders from engaging in costly conflicts.     

Positional Independence in Preference Aggregation: A Remark

In a recent article, Quesada (Soc Choice Welfare 20 363–370, 2003) showed that if, for strict preferences, a unique strongly unanimous Choice Function (CF) is used to aggregate preferences position-wise then the resulting Social Welfare Function (SWF) is dictatorial. We show that this result is still true if one allows the use of different choice functions, one for each position. We also show that allowing choice functions not to be unanimous leads to SCW that are perm-dictatorial or imposed. We also show a way to set a dual problem to the one exposed in Que03, namely only perm-dictatorial and imposed SWFs can be decomposed into several Dual Choice Functions.An anonymous referee is thanked for his useful remarks.