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Sharpless NE 《Science of aging knowledge environment : SAGE KE》2003,2003(33):PE24
Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications (1, 2) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well. 相似文献
224.
The purpose of the present work was to investigate the assumption that the lives of lesbians are easier today. When exploring the hypothesis that identity events (e.g., coming out to parents) among lesbian women have changed over time and happen earlier in life today, we expected to find several time period effects. Two national samples obtained through mailed questionnaires were compared, 1986 (n = 123) and 2005 (n = 236), age range 20-49. Time period effects were found, including informants reporting identifying as lesbian earlier in life. Time period effects, however, were not found regarding relational identity events such as informing others about one's identity status. The findings did not reveal any conclusive evidence that it is easier to establish a lesbian lifestyle today. 相似文献
225.
This longitudinal study examined the associations between relationship abuse, coping variables, and mental health outcomes among a sample of battered women obtained from shelter and nonresidential community agencies (N = 61). Sexual aggression was a stronger predictor of poorer mental health than was physical assault. Engagement coping strategies were generally predictive of positive mental health, and disengagement coping strategies were generally predictive of poorer mental health. Results highlight the complexity of the associations between different forms of relationship abuse, coping strategies, and mental health among this population. 相似文献
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Many agencies require population estimates and projections by ethnic group. These projections need ethnic-specific, age-specific fertility rates (ASFRs) but their inclusion is challenging since ethnicity is not recorded at birth registration. In this paper maternity data are used in a case study of electoral wards in Bradford, West Yorkshire, to develop fertility rates for small populations for a 1991 based projection. The challenge is to capture local variations in fertility by ethnic group when data are sparse. Small areas were grouped together using cluster analysis to define combinations with similar sociodemographic and fertility experiences so that sparse data could be aggregated to estimate reliable ethnic-specific fertility rates. For comparison, the data were aggregated into the 1991 Office for National Statistics area type classification. Fertility rates by single year of age for all area types were smoothed using the Hadwiger function. For the White ethnic group there were sufficient births to create ethnic-specific, ward-level ASFRs. For other ethnicities grouping of areas was necessary. The accuracy of the ASFRs in predicting births was assessed using mean absolute percentage error. Results show that for some minority groups district-level ethnic-specific fertility rates produced the most accurate birth estimates even though they were based on a larger area. This implies that rates created may be informative about the local area for White ethnic type but not in the same way for smaller ethnic groups. In terms of grouping strategies we recommend that existing classifications are assessed to determine how well variations in rates are stratified before embarking on a custom scheme. Where population sub-groups are small in some areas, it may be more reliable to use rates derived for larger areas and apply these to local populations. Inevitably, the rates used in a projection are a compromise but hopefully will still capture important dimensions of population change. 相似文献
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Norman Blaikie 《International Journal of Social Research Methodology》2018,21(5):635-641
The debate on determining sample size in qualitative research is confounded by four fundamental methodological issues: the exclusive focus on theme analysis; the diverse and imprecise use of ‘qualitative’; a reliance on only two logics of inquiry, induction and deduction, and the occasional confusion of abduction with induction; and a general lack of recognition of the importance of differences in ontological assumptions. Embedded in these issues is an unwarranted acceptance of limited associations between certain assumptions, logics, forms of data, and methods of data collection/generation and analysis. What is required is a reformulation of the problem and its discussion with reference to ontological assumptions and logics of inquiry. 相似文献
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Kelsey P. Norman 《Journal of ethnic and migration studies》2019,45(1):42-60
What determines policies toward migrants and refugees in the transit-turned-host countries? Compared to the vast literature examining migration to Europe and North America, we know relatively little about why ‘newer’ host states pursue a liberal strategy with access to residency, employment and services on par with citizens, or what drives them to treat migrants and refugees with exclusion. This paper argues that there is a third choice: the idea of indifference-as-policy. Indifference refers to indirect action on the part of the host state, whereby a state defers to international organisations and civil society actors to provide basic services to migrants and refugees. The paper uses data collected over two years in Egypt, Morocco and Turkey to examine how this tripartite understanding of engagement maps onto empirical reality. Drawing on this analysis, the argument in this paper is two-fold. First, indifference is a strategic form of engagement utilised by host states, and that it creates a specific type of environment that allows for the de facto integration of migrants and refugees. Second, even when host states take steps toward a more liberal engagement strategy, examining policy outcomes, rather than outputs, demonstrates that indifference is still the dominant policy. 相似文献