A weighted spatial median for clustered data

A weighted spatial median is proposed for the multivariate one-sample location problem with clustered data. Its limiting distribution is derived under mild conditions (no moment assumptions) and it is shown to be multivariate normal. Asymptotic as well as finite sample efficiencies and breakdown properties are considered, and the theoretical results are supplied with illustrative examples. It turns out that there is a potential for meaningful gains in estimation efficiency: the weighted spatial median has superior efficiency to the unweighted spatial median particularly when the cluster sizes are widely disparate and in the presence of strong intracluster correlation. The unweighted spatial median for clustered data was considered earlier by Nevalainen et al. (Can J Statist, in press, 2007). The proposed weighted estimators provide companion estimates to the weighted affine invariant sign test proposed recently by Larocque et al. (Biometrika, in press, 2007). An affine equivariant weighted spatial median is discussed in parallel.     

k-Step shape estimators based on spatial signs and ranks

In this paper, the shape matrix estimators based on spatial sign and rank vectors are considered. The estimators considered here are slight modifications of the estimators introduced in Dümbgen (1998) and Oja and Randles (2004) and further studied for example in Sirkiä et al. (2009). The shape estimators are computed using pairwise differences of the observed data, therefore there is no need to estimate the location center of the data. When the estimator is based on signs, the use of differences also implies that the estimators have the so called independence property if the estimator, that is used as an initial estimator, has it. The influence functions and limiting distributions of the estimators are derived at the multivariate elliptical case. The estimators are shown to be highly efficient in the multinormal case, and for heavy-tailed distributions they outperform the shape estimator based on sample covariance matrix.     

Generalized Mann–Whitney Type Tests for Microarray Experiments

New statistical procedures are introduced to analyse typical microRNA expression data sets. For each separate microRNA expression, the null hypothesis to be tested is that there is no difference between the distributions of the expression in different groups. The test statistics are then constructed having certain type of alternatives in mind. To avoid strong (parametric) distributional assumptions, the alternatives are formulated using probabilities of different orders of pairs or triples of observations coming from different groups, and the test statistics are then constructed using corresponding several‐sample U‐statistics, natural estimates of these probabilities. Classical several‐sample rank test statistics, such as the Kruskal–Wallis and Jonckheere–Terpstra tests, are special cases in our approach. Also, as the number of variables (microRNAs) is huge, we confront a serious simultaneous testing problem. Different approaches to control the family‐wise error rate or the false discovery rate are shortly discussed, and it is shown how the Chen–Stein theorem can be used to show that family‐wise error rate can be controlled for cluster‐dependent microRNAs under weak assumptions. The theory is illustrated with an analysis of real data, a microRNA expression data set on Finnish (aggressive and non‐aggressive) prostate cancer patients and their controls.     

Affine Invariant Multivariate Sign and Rank Tests and Corresponding Estimates: a Review

The paper reviews recent contributions to the statistical inference methods, tests and estimates, based on the generalized median of Oja. Multivariate analogues of sign and rank concepts, affine invariant one-sample and two-sample sign tests and rank tests, affine equivariant median and Hodges–Lehmann-type estimates are reviewed and discussed. Some comparisons are made to other generalizations. The theory is illustrated by two examples.     

On the multivariate spatial median for clustered data

The authors consider the multivariate one-sample location problem with clustered data from a nonparametric viewpoint. They propose the spatial median and its affine equivariant version as companion estimators to the affine invariant sign test of Larocque (2003). They extend the asymptotics of the proposed estimators to cluster dependent data and explore the limiting as well as finite-sample efficiencies for multivariate Student distributions. They demonstrate that the efficiency of the spatial median suffers less from intracluster correlation than the mean vector. They use data on the well-being of pupils in Finnish schools to illustrate their work.     

On Permutation Tests in Multiple Regression and Analysis of Covariance Problems

We introduce distribution-free permutation tests and corresponding estimates for studying the effect of a treatment variable x on a response y. The methods apply in the presence of a multivariate covariate z. They are based on the assumption that the treatment values are assigned randomly to the subjects.