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401.
New technology-based firms, particularly those that develop their business around a new technological platform, are likely to be impacted by globalization, in terms of both pace of innovation and pressure of competition. For these firms, strategic decisions and growth processes are characterized by a deep inter-relationship amongst the processes of internationalization, innovation and entrepreneurship; processes which have tended to be examined independently in distinct bodies of literature. In practice strategic decisions concern each of these processes and address issues such as organizational boundaries, location of the operational activities, what activities to focus on and selection of value partners. The business model by which firms operate needs also to accommodate the spatial dimensions indicated by globalization; and the emergence of global technology markets. Little is known to date about the extent to which business models accommodate or are adapted to internationalization, innovation and entrepreneurship. This paper presents a review of the business model literature from which a generic business model framework is derived, identifying and introducing the main elements of these processes as the firms?? focus, modus and locus. This contribution makes a clear distinction between the business model and the strategy concepts and highlights the relevance of location decisions??not considered by extant business model literature to date. While our discussion draws on the high technology new venture as our primary example, we believe our business model conceptualization has general applicability.  相似文献   
402.
The global expansion of free enterprise has been underway for some time, and the challenges for global companies are well‐known. Companies often operate in economically blighted communities and in corrupt environments without a rule of law. At the same time Western‐based global corporations are under increasing public pressure to take on responsibilities to these communities that are often beyond their expertise or economic purview. For example, at the 2008 Davos meetings Bill Gates proposed the idea of “creative capitalism, challenging business to ‘meet the needs of the poor in ways that generate profits’...” In what follows I shall argue that while there have been many successful global ventures, the Gates’ challenge requires academics and managerial leaders to rethink their mind sets and expand their thinking about what we mean by globalization, poverty, and the multiple dimensions of free enterprise.  相似文献   
403.
随着社会不断发展,心理健康问题日益受到人们的普遍关注.尤其在大学校园中,一些学生因为远离父母、缺乏独立生活能力等原因受到了心理疾病的困扰.围绕大学生心理素质问题展开探讨,对大学生心理健康标准、常见心理矛盾及问题、优化心理素质进行了详细阐述.  相似文献   
404.
Because borderline adolescents are fixated at a very early stage of childhood, they have not sufficiently attained the essential capabilities for future growth and development. This article presents a psychosocial model, intended for use in a residential and day treatment center, that addresses the conceptual states necessary for growth, development, and potentialities. It is based on a review of the literature on borderline adolescents and their families, this writer's wwn practice experience, and ecosystems theory, object relations theory, and the theory of structural family therapy.  相似文献   
405.
406.
Over two billion dollars was awarded by the U.S. Department of Health and Human Services (HHS) in research funding from 2010 to March 2012 to institutions receiving a grade of "C," "D," or "F" on their conflict of interest policies, as determined by the American Medical Student Association's scorecard on conflict of interest policies. More institutional oversight is needed with regard to assuring conflict of interest policies at U.S. research institutions are adequate. As stewards of public funds, HHS should require a minimum standard which institutional conflict of interest policies should meet, beyond current regulatory requirements, before granting funding.  相似文献   
407.
The purpose of this article is to investigate estimation and hypothesis testing by maximum likelihood and method of moments in functional models within the class of elliptical symmetric distributions. The main results encompass consistency and asymptotic normality of the method of moments estimators. Also, the asymptotic covariance matrix of the maximum likelihood estimator is derived, extending some existing results in elliptical distributions. A measure of asymptotic relative efficiency is reported. Wald-type statistics are considered and numerical results obtained by Monte Carlo simulation to investigate the performance of estimators and tests are provided for Student-t and contaminated normal distributions. An application to a real dataset is also included.  相似文献   
408.
Bayesian alternatives to the classical F test comparing two population variances are explored. Shoemaker (2003 Shoemaker , L. H. ( 2003 ). Fixing the F test for equal variances . The Amer. Statistician 57 : 105114 .[Taylor & Francis Online], [Web of Science ®] [Google Scholar]) suggested two adjustments to the F test due to it being very sensitive to the normal assumption of the two populations. A simulation study is performed to compare the Bayesian alternatives to the F test and Shoemaker's adjusted F tests as well as to the Levene/Brown–Forsythe and the squared rank nonparametric tests. The Bayesian alternatives assume a normal parent distribution and non informative priors and the conjugate prior for the variances; in addition, an exponential power distribution is considered as the parent distribution with a non informative prior for the variances. The latter looks to be very promising provided that a suitable value of a parameter which measures the extent of non normality is chosen.  相似文献   
409.
Abstract

We develop an analytic likelihood approach for a four-state CTMC by solving the backwards Kolmogorov differential equations, reducing this bias in transition rate estimates. A simulation study is performed to assess the performance of this new method and confirms that it achieves good coverage probabilities with low bias and standard errors. Finally, we analyzed data from Project SUCCESS to estimate the study each participant’s transitions among behavioral stage, consisting of risky drinking and possible ineffective using of contraception, which comprise the primary endpoint of risk of an alcohol-exposed pregnancy.  相似文献   
410.
In this paper, we describe the development and history of the Keeping Foster Parents Trained and Supported (KEEP) foster-parent training intervention. KEEP intervention represents a modified version of the Multidimensional Treatment Foster Care intervention developed by interventionists at the Oregon Social Learning Center and is designed to provide training and support for children ages 5–11 in regular foster care. We also report on the initial findings from a programme of research focused on determining the effectiveness of the intervention. Thus far, the results indicate that the intervention is effective in reducing child behaviour problems and that the effects of the intervention are mediated through changes in parenting behaviour. There is also evidence that the KEEP foster-parent training intervention increases the chances of a positive change of placement (e.g. child reunited with biological parents) and mitigates the negative risk-enhancing effect of a history of multiple placements. We conclude with a discussion of unanswered questions and directions for future research.  相似文献   
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