The hunt for a cure for Parkinson's disease

Several exciting new scientific advances have been made in the past decade toward both understanding the causes of and finding a cure for Parkinson's disease. Heartened by an acceleration in research findings in the past several years, the government has recently called for an infusion of funds from both the National Institutes of Health and private foundations into this burgeoning area of biomedical research. Most currently available conventional treatments for the disease only temporarily delay symptom presentation while doing nothing to halt disease progression. However, the rapidly accelerating pace of research in this field has left researchers hopeful that Parkinson's will be the first major age-related neurodegenerative disease for which we have a viable cure. In this article, advances in various areas of Parkinson's disease research are reviewed.     

Restructuring for Whom? Race,Class, Gender,and the Ideology of Invisibility

This paper examines how changes resulting from economic restructuring affect views of racial inequality across different race, class, and gender groups. First reviewing some of the consequences of restructuring for different race, class, and gender groups, the paper also reviews research documenting the different views of racial inequality held by dominant and subordinate groups. The paper concludes by examining how race-blind ideologies affect discussions of race and multiculturalism and suggests that race-blind thinking has thwarted teaching about structural racism.     

Welfare municipalities: economic resources or party politics? Norwegian local government social programs of the 1920s

This article analyses the introduction of Norwegian local government social security programs for the elderly, disabled persons, widows and single mothers in the 1920s. The role of local government as an agent and initiator of welfare state development has been for the most part neglected within the welfare state literature. Indeed, the first social security programs in Norway were introduced by local governments, affecting nearly half of the population. Even if these programs were not very generous compared with the social security programs of our time, many of them were equal to, or even more generous than, the national pension scheme introduced in 1936. This article examines what distinguished the social security municipalities from those that did not implement such programs, and the variation in generosity profiles. The conclusion is that the main determinant regarding the implementation and generosity of the local social security programs is the political strength of the two Norwegian socialist parties at the time – the Social democratic party and the Labour party – both being too impatient to wait for a national social security plan, and both being willing to mobilise economic resources through taxation and borrowing.     

L'attitude des employeurs à l'égard des réfugiés: les résultats d'une enquête suédoise

En se fondant sur une enquête auprès des entreprises, menée à grande échelle en Suède, les auteurs concluent à une hétérogénéité importante des attitudes par rapport à la main‐d'?uvre immigrée d'origine réfugiée, au comportement professionnel de ces travailleurs, à leur niveau de salaire et à la discrimination à leur égard, même si une expérience préalable en la matière limite les attitudes négatives. Pour la majorité des entreprises, les salaires minima conventionnels ne constituent pas un obstacle majeur au recrutement de réfugiés. Cependant, celles qui emploient beaucoup de réfugiés estiment que la réduction de ces seuils serait très bénéfique à l'emploi.     

Democracy,Redistribution, and Political Participation: Evidence From Sweden 1919–1938

In this paper, we compare how two different types of political regimes—direct versus representative democracy—redistribute income toward the relatively poor segments of society after the introduction of universal and equal suffrage. Swedish local governments are used as a testing ground since this setting offers a number of attractive features for a credible impact evaluation. Most importantly, we exploit the existence of a population threshold, which partly determined a local government's choice of democracy to implement a regression‐discontinuity design. The results indicate that direct democracies spend 40–60 percent less on public welfare. Our interpretation is that direct democracy may be more prone to elite capture than representative democracy since the elite's potential to exercise de facto power is likely to be greater in direct democracy after democratization.     

Stair-ascent performance in elderly women: effect of explosive strength training

Explosive-type strength training may alter kinetics and neuromuscular activity during stair ascent in elderly women. This may improve functional ability. Nineteen women (69.7 ± 3.4 yr) were randomly allocated to strength training (TG; twice per wk, 12 wk) or a control group (CG). Stair ascent was assessed at self-chosen (AFV), standardized (ASV), and maximal velocity (AMV) pre- and posttraining. Ground-reaction force (GRF) and EMG quantified kinetics and neuromuscular activity. After training, TG increased AMV and AFV velocity by 8% (p = .02) and 17% (p= .007), respectively (TG vs. CG; p< .05). This was accompanied by elevated rectus femoris EMG (from 21% to 48%, p< .047). At AFV, TG increased GRF first peak force 4% (p= .047), and CG increased second peak force 5% (p = .036). Muscle coactivation remained unaltered in both groups. Explosive-type strength training led to enhanced stair-climbing performance at maximal and self-chosen speed, reflecting an improved functional ability.     

Fatigue effects of noise on aeroplane mechanics

Subjective fatigue and reaction time performance were measured in a group of 24 aeroplane mechanics, during 1 week of high noise exposure and 1 week of low noise exposure. Subjective ratings were collected before and after each work day. On the last day of each week subjects also completed a reaction time task before and after work. The mechanics felt more sleepy and less energetic during the high noise week. This effect was most evident towards the end of the day and there was a build-up of the effect during the week. Reaction times were prolonged during the high noise week. Possible confounding factors are discussed and found to be less likely explanations of the effects.     

Score test of homogeneity for survival data

If follow-up is made for subjects which are grouped into units, such as familial or spatial units then it may be interesting to test whether the groups are homogeneous (or independent for given explanatory variables). The effect of the groups is modelled as random and we consider a frailty proportional hazards model which allows to adjust for explanatory variables. We derive the score test of homogeneity from the marginal partial likelihood and it turns out to be the sum of a pairwise correlation term of martingale residuals and an overdispersion term. In the particular case where the sizes of the groups are equal to one, this statistic can be used for testing overdispersion. The asymptotic variance of this statistic is derived using counting process arguments. An extension to the case of several strata is given. The resulting test is computationally simple; its use is illustrated using both simulated and real data. In addition a decomposition of the score statistic is proposed as a sum of a pairwise correlation term and an overdispersion term. The pairwise correlation term can be used for constructing a statistic more robust to departure from the proportional hazard model, and the overdispesion term for constructing a test of fit of the proportional hazard model.     

The development and nature of the construct touch avoidance

Development of two touch-avoidance measures via factor analysis are reported. Touch avoidance is a nonverbal communication predisposition that consists of two dimensions, same-sex touch avoidance and opposite-sex touch avoidance. The results are replicated across two distinct samples with consistent reliability of measurement. Touch avoidance is then related to communication apprehension, self-disclosure, self-esteem, and a series of cultural role variables. The cultural role variables seem to have the greatest relationship with the two measures of touch avoidance. A program for future research on touch avoidance is also discussed.     

About the contributors

This paper first maps the distribution of indigenous gambling in cultures around the world. On the basis of extensive ethnographic and historical evidence, it is concluded that gambling is not a universal phenomenon; prior to the era of European colonisation, non-gambling societies appear to have covered large areas of the globe. The pattern of gambling and non-gambling peoples and nations invites speculation and investigation. The second part of the paper reviews and critically discusses statistical cross-cultural studies that have aimed to uncover factors that promote or restrain the playing of games of chance and the practice of gambling. Some of these factors, which allow us to predict to a certain extent the presence and intensity of gambling in societies, are: the presence of commercially used money, social inequality, societal complexity, and the presence of certain kinds of competitive inter-tribal relations.