Physiologically Based Liver Modeling and Risk Assessment

Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments.     

A Comparison of Partially Adaptive and Reweighted Least Squares Estimation

The small sample performance of least median of squares, reweighted least squares, least squares, least absolute deviations, and three partially adaptive estimators are compared using Monte Carlo simulations. Two data problems are addressed in the paper: (1) data generated from non-normal error distributions and (2) contaminated data. Breakdown plots are used to investigate the sensitivity of partially adaptive estimators to data contamination relative to RLS. One partially adaptive estimator performs especially well when the errors are skewed, while another partially adaptive estimator and RLS perform particularly well when the errors are extremely leptokur-totic. In comparison with RLS, partially adaptive estimators are only moderately effective in resisting data contamination; however, they outperform least squares and least absolute deviation estimators.     

Sources of family violence

This paper suggests a direction for the exploration of the causes of family violence. Explanatory models of family violence were considered in this regard, with the recommendation that a multi-determined model should be considered to ensure the most accurate explanation. We suggest that family violence will be best understood and prevented or alleviated, if a model is used that considers the interaction of structural violence and the personality features of all the family members.     

On the existence and uniqueness of maximizers of two likelihood functions

While applying theclassical maximum likelihood method for a certain statistical inference problem, Smith and Weissman [5] have noted that there are conditions under which the likelihood function may be unbounded above or may not possess local maximizers. Ariyawansà and Templeton [1] have derived inference procedures for this problem using the theory of structural inference [2,3,4]. Based on numerical experience, and without proof, they state that the resulting likelihood functions possess unique, global maximizers, even in instances where the classical maximum likelihood method fails in the above sense. In this paper, we prove that under quite mild conditions, these likelihood functions that result from the application of the theory of structural inference are well-behaved, and possess unique, global maximizers. This research was supported in part by the Applied Mathematical Sciences subprogram of the U.S. Department of Energy under contract W-31-109-Eng-38 while the author was visiting the Mathematics and Computer Science Division of Argonne National Laboratory, Argonne, Illinois.     

Sampling Strategies for Toxic Air Contaminants

Annual concentrations of toxic air contaminants are of primary concern from the perspective of chronic human exposure assessment and risk analysis. Despite recent advances in air quality monitoring technology, resource and technical constraints often impose limitations on the availability of a sufficient number of ambient concentration measurements for performing environmental risk analysis. Therefore, sample size limitations, representativeness of data, and uncertainties in the estimated annual mean concentration must be examined before performing quantitative risk analysis. In this paper, we discuss several factors that need to be considered in designing field-sampling programs for toxic air contaminants and in verifying compliance with environmental regulations. Specifically, we examine the behavior of SO2, TSP, and CO data as surrogates for toxic air contaminants and as examples of point source, area source, and line source-dominated pollutants, respectively, from the standpoint of sampling design. We demonstrate the use of bootstrap resampling method and normal theory in estimating the annual mean concentration and its 95% confidence bounds from limited sampling data, and illustrate the application of operating characteristic (OC) curves to determine optimum sample size and other sampling strategies. We also outline a statistical procedure, based on a one-sided t-test, that utilizes the sampled concentration data for evaluating whether a sampling site is compliance with relevant ambient guideline concentrations for toxic air contaminants.     

Coaching für Führungskräfte im Krankenhaus Baustein einer Strategie zum Total Quality Management

Coaching of managers in hospitals as component of a total quality management strategy The author delineates the changed conditions of hospitals at the beginning of the new millenium. In order to be up to date with the growing challenges and the need for change a Total Quality Management (TQM) is necessary. This TQM sees the satisfaction of clients and of employees as crucial for all reorganization processes. The realization in everyday hospital life requires a total personnel development concept, with special regard to the managers and their specific needs for support by supervisors resp. coaches.     

Surname analysis for estimating local concentration of Hispanics and Asians

Surname analysis is a potentially useful technique for identifying members of particular racial, ethnic, or language communities within a population. We review the existing state of the art for identifying persons of Hispanic or Asian origin, based on surnames distinctive of each group. We describe the logic of surname analysis, profile several available surname dictionaries, and illustrate their applications in local redistricting. Results of our ongoing validation studies suggest promising future directions for improving accuracy and broadening applications.This article is based on a paper presented at the annual Population Association of America meetings at Cincinnati, 1 April 1993.