Operating characteristics of a Simon two-stage phase II clinical trial design incorporating continuous toxicity monitoring

Phase II clinical trials are usually designed to measure efficacy, but safety is also an important end point. Previous authors recommended a method to monitor toxic events after each patient is enrolled, which is also known as continuously monitoring the toxicity. In this work, we investigate combining the usual Simon two-stage design to monitor response with the continuous toxicity monitoring methodology. Theoretical justification is given for the nominal size, probability of early termination, and average sample size under the null hypothesis of the combined testing procedure. A series of simulations are performed to investigate the performance of the combined procedure.     

An Empirical Investigation into Factors Relating to the Adoption of Executive Information Systems: An Analysis of EIS for Collaboration and Decision Support*

This study focuses on the organizational adoption of Executive Information Systems (EIS). A distinction is made between two related, complementary EIS capabilities—EIS for collaboration support (EIS_c) and EIS for decision support (EIS_d). EIS_c is relatively standardized and replicable, while EIS_d has to be developed in situ given the specific characteristics of the user and task. The adoption process is conceptualized as an initial transition from a state of nonadoption to adoption (adoption status) and subsequent internal propagation of the technology (adoption level). Data collected from a national survey are used to test hypotheses between identified contextual variables and the adoption status and adoption level of EIS_c and EIS_d. Adopters and nonadopters of both EIS_c and EIS_d do not differ in their organization size, suggesting that the traditional paradigm of “EIS as a technology for large firms” is no longer true. Environmental uncertainty is found to promote the transition from a state of nonadoption to adoption of both EIS_c and EIS_d while continuing to catalyze the internal propagation of EIS_d. While no differences are observed in IS department size between adopters and nonadopters of EIS_c, our results suggest that larger IS departments provide the resource base to explore the less standardized of the two capabilities, EIS_d. IS support is also found to be critical for the subsequent internal propagation of EIS_d. Furthermore, the adoption level of both EIS_c and EIS_d are found to be promoted by top management support. Implications of these results are discussed for the organizational adoption of EIS.     

Does Size Matter? Comparing Medium‐Term Cost‐Effectiveness of Group Homes with Institutional Care in South Korea

Using unique 5‐year longitudinal data on Korean children in group homes and those under institutional care, this paper compared the medium‐term cost‐effectiveness of group homes and that of institutional care facilities in terms of developmental outcomes. Results from propensity score matching estimation show that children in group homes tend to have more desirable positive outcomes and fewer behavioral problems in the medium term to a statistically significant margin. The cost‐effectiveness ratio of being placed in a group home is consistently higher than placement in an institutional care facility. That is, for one dollar spent on an out‐of‐home care service, we anticipate the children in group homes have more desirable outcomes in the medium term than their counterparts in institutional care facilities.     

A new class of estimators of finite population mean in sample surveys

This article suggests the class of estimators of population mean of study variable using various parameters related to an auxiliary variable with its properties in simple random sampling. It has been identified that the some existing estimator/classes of estimators are members of suggested class. It has been found theoretically as well as empirically that the suggested class is better than the existing methods.     

Ergonomic evaluation of conventional and improved methods of aonla pricking with women workers

Conventional and improved methods of aonla pricking were evaluated ergonomically on an experiment conducted for 20 minute with women workers. The working heart rate, energy expenditure rate, total cardiac cost of work and physiological cost of work with conventional tools varied from 93-102 beats.min-1, 6-7.5 kJ.min-1, 285-470 beats, 14 -23 beats.min-1 while with machine varied from 96-105 beats.min-1, 6.5-8 kJ.min-1 , 336-540 beats, 16-27 beats.min-1 respectively. OWAS score for conventional method was 2 indicating corrective measures in near future while with machine was 1 indicating no corrective measures. Result of Nordic Musculoskeletal Questionnaire revealed that subjects complaint of pain in back, neck, right shoulder and right hand due to unnatural body posture and repetitive movement with hand tool. Moreover pricking was carried out in improper lighting conditions (200-300 lux) resulting into finger injuries from sharp edges of hand tool, whereas with machine no such problems were observed. Output with machine increased thrice than hand pricking in a given time. Machine was found useful in terms of saving time, increased productivity, enhanced safety and comfort as involved improved posture, was easy to handle and operate, thus increasing efficiency of the worker leading to better quality of life.     

Lean Six Sigma implementation: modelling the interaction among the enablers

Abstract

Lean Six Sigma (LSS) methodology has been acquiring a prominent position in organisations. The aim of this study is to demonstrate an approach to LSS implementation in organisations using the development of a hypothetical model based on interpretive structural modelling (ISM) and fuzzy Matriced Impacts Croisés Multiplication Appliquée á un Classement (fuzzy MICMAC) analysis phenomenon. Seventy Lean Six Sigma enablers (LSSEs) have been identified through extensive literature review and out of which 40 most important LSSEs were finalised through opinions of experts both from industry and academia. Furthermore, the valuable expert opinions have been applied to determine contextual relationships between these significant LSSEs and a hierarchical model has been created based on an ISM. The fuzzy MICMAC analysis has also been utilised to classify the enablers based on the dependence and driving power, and validate the created ISM-based model. The developed hierarchical model will assist to understand interrelationships and interdependencies among the identified LSSEs. Having high driving and low dependence power, the LSSEs have strategic significance because of their driving character. On the other hand, having high dependence and low driving power, LSSEs are more performance orientated. The mutual influence, driving and dependence power of LSSEs render valuable information to top management to distinguish between independent and dependent LSSEs. An organisation desiring of adopting LSS may get benefited by the understanding of LSSEs and their interactions.     

Context and interpretation in laboratory experiments: The case of reciprocity

The existing literature acknowledges that a mismatch between the experimenter’s and the subjects’ models of an experimental task can adversely affect the interpretation of data from laboratory experiments. We primarily focus on experiments designed to test a hypothesis by comparing behavior across two or more games and highlight the drawbacks of using a between-subjects design or a within subjects design. An alternative design for laboratory experiments is proposed which may alleviate this concern especially in studies of social preferences. We argue that the proposed design does not introduce any conceptual problems in addition to those that are already present in the between and within subjects designs and may alleviate some of the problems inherent to these designs in certain cases. We also use the proposed design to answer some questions that have attracted continued attention in the literature on social preferences in general and reciprocity in particular.     

英美法系与大陆法系比较研究

在世界法律大家族中 ,英美判例法独具特色 ,为众多学者所关注与研究。尽管如此 ,在判例法特色及其历史渊源问题上仍有讨论余地。本文在相对应于制定法的基础上 ,从立法、司法环节和法的价值角度 ,对英美判例法特色进行再认识     

Meta‐analysis of depression among marriage‐based migrant women in South Korea

Using meta‐analysis, this study examines the effect sizes of the variables related to depression and the moderating effects of depression among marriage‐based migrant women in South Korea to determine the implications for human service fields. This study identified 25 peer‐reviewed articles from 2000 to 2014 published in either Korean or in English. Results showed that (i) Korean language proficiency and economic hardship had significant effect sizes relative to depression; (ii) the psychosocial characteristics (i.e., acculturative stress, social support, marital satisfaction, life satisfaction, and self‐esteem) of this population had medium effect sizes relative to depression; and (iii) use of the Center for Epidemiological Studies Depression scale, residence in agricultural areas, average age, and average length of stay in Korea had significant moderating effects. Based on these results, the authors discuss social work practices and policies for this population, suggesting the priorization of marriage‐based migrant women in agricultural areas who have lived in Korea for short lengths of time.