Type I error rates from likelihood‐based repeated measures analyses of incomplete longitudinal data

The last observation carried forward (LOCF) approach is commonly utilized to handle missing values in the primary analysis of clinical trials. However, recent evidence suggests that likelihood‐based analyses developed under the missing at random (MAR) framework are sensible alternatives. The objective of this study was to assess the Type I error rates from a likelihood‐based MAR approach – mixed‐model repeated measures (MMRM) – compared with LOCF when estimating treatment contrasts for mean change from baseline to endpoint (Δ). Data emulating neuropsychiatric clinical trials were simulated in a 4 × 4 factorial arrangement of scenarios, using four patterns of mean changes over time and four strategies for deleting data to generate subject dropout via an MAR mechanism. In data with no dropout, estimates of Δ and SE_Δ from MMRM and LOCF were identical. In data with dropout, the Type I error rates (averaged across all scenarios) for MMRM and LOCF were 5.49% and 16.76%, respectively. In 11 of the 16 scenarios, the Type I error rate from MMRM was at least 1.00% closer to the expected rate of 5.00% than the corresponding rate from LOCF. In no scenario did LOCF yield a Type I error rate that was at least 1.00% closer to the expected rate than the corresponding rate from MMRM. The average estimate of SE_Δ from MMRM was greater in data with dropout than in complete data, whereas the average estimate of SE_Δ from LOCF was smaller in data with dropout than in complete data, suggesting that standard errors from MMRM better reflected the uncertainty in the data. The results from this investigation support those from previous studies, which found that MMRM provided reasonable control of Type I error even in the presence of MNAR missingness. No universally best approach to analysis of longitudinal data exists. However, likelihood‐based MAR approaches have been shown to perform well in a variety of situations and are a sensible alternative to the LOCF approach. MNAR methods can be used within a sensitivity analysis framework to test the potential presence and impact of MNAR data, thereby assessing robustness of results from an MAR method. Copyright © 2004 John Wiley & Sons, Ltd.     

The Forgotten Million Unemployed

In July 1985 the National Council for Voluntary Organisations launched a campaign for "action for the forgotten million"— the four out of every five long-term unemployed people who receive no practical support from the public services, apart from their benefits. The author of the National Council discussion document outlines some of the major issues which will need to be faced. In particular, he argues that public debate tends to concentrate too narrowly on specific initiatives and individual programmes. Instead, there is a need to consider the rights of all long-term unemployed people, and the needs of the group as a whole.     

小额信贷之违约概率模型:特别考虑异质性

在新巴塞尔资本协议(New Basel Capital Accord)对金融全球化的冲击及金融机构改善资产质量及合并政策的影响下,我国台湾地区金融业进入激烈合并竞争的时代.许多银行颇受降低逾放比率及增加净值报酬率与资产报酬率两难之困扰.消费性信用贷款产品利差大、风险分散,是金融机构授信经营极重要的产品.实证结果显示,采用世代研究(cohort study)建立之模型对样本数据之拟合程度较个案对照研究法(case-control study)的解释变异量为佳,且较符合新巴塞尔资本协议规定及科学程序.虽然Logistic 回归模型在建立逾期概率模型上广泛地被使用,但要求存在于同构型的变异数Var=np(1-p)假设上,且在数据分析上常因为出现变异数之异质性问题,故可采用调整变异数异质性之方法.     

Form Perception of Partly Occluded Shapes in 4‐Month‐Old Infants

Two habituation experiments were conducted to investigate how 4‐month‐old infants perceive partly occluded shapes. In the first experiment, we presented a simple, partly occluded shape to the infants until habituation was reached. Then we showed either a probable completion (one that would be predicted on the basis of both local and global cues) or an improbable completion. Longer looking times were found for the improbably completed shape (compared to probable and control conditions), suggesting that the probable shape was perceived during partial occlusion. In the second experiment, infants were habituated to more ambiguous partly occluded shapes, where local and global cues would result in different completions. For adults, the percept of these shapes is usually dominated by global influences. However, after habituation the infants looked longer at the globally completed shapes. These results suggest that by the age of 4 months, infants are able to infer the perceptual completion of partly occluded shapes, but for more ambiguous shapes, this completion seems to be dominated by local influences.     

施工企业危机管理及其经济分析

危机管理的目的是为了避免和减少危机的损害,是一场"防御性的战斗",也是一项系统工程。论文结合竞争激烈的施工企业市场实际,从施工企业危机管理入手,阐述了施工企业危机管理目前的共性内容,并通过分析对危机管理的重要意义、危机管理效果和经济效果的衡量等问题,进一步通过施工企业危机管理的经济分析对危机管理投入、所得的界定,研究了危机管理投入的量化及归一化,以及危机管理所得的量化及归一化问题,得出单位投入所带来的整体稳定态势,其值越大表明危机管理越有效。可为施工企业开展此项工作提供一定的理论指导。     

中国古代神话传说中的技术意识

作为对历史过程的一个解释系统，中国古代神话中蕴含着对中国古代技术价值和功能的特定理解。在对技术创世、技术过程、技术工具性价值的解读中，呈现出天人合一、由技人道、制器尚象等渗透中国传统文化精髓的技术意识；而有关技术的误读，则流露出浓厚的“以道驭术”的技术文化观。这些技术意识通过神话作品的传播，潜移默化地深入人心，进而又进一步影响现实中的技术。     

Consumption and Saving Behavior of Older and Younger Baby Boomers in Korea

The 1998 Korean Survey of Family Income and Expenditures was used to examine the overall consumption and saving behavior of Korean baby boomers and compared the differences in consumption and saving behavior between older and younger boomers. The t -test results indicated that the younger boomers allocated a significantly higher percentage of their expenditures on food away from home, household appliances, transportation and communication than did the older boomers, whereas the older boomers spent higher amounts and allocated larger budget shares on their children's education than did the younger boomers. The results of Ordinary Least-Squares (OLS) regression analysis showed that, holding other factors constant, older boomers not only spent significantly more in the total consumption expenditures and education expenditures, but older boomers also saved significantly less than did younger boomers.