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Sample size reestimation in a crossover, bioequivalence study can be a useful adaptive design tool, particularly when the intrasubject variability of the drug formulation under investigation is not well understood. When sample size reestimation is done based on an interim estimate of the intrasubject variability and bioequivalence is tested using the pooled estimate of intrasubject variability, type 1 error inflation will occur. Type 1 error inflation is caused by the pooled estimate being a biased estimator of the intrasubject variability. The type 1 error inflation and bias of the pooled estimator of variability are well characterized in the setting of a two‐arm, parallel study. The purpose of this work is to extend this characterization to the setting of a crossover, bioequivalence study with sample size reestimation and to propose an estimator of the intrasubject variability that will prevent type 1 error inflation. 相似文献
23.
THE USE OF CHILD-CENTERED PLAY THERAPY AND FILIAL THERAPY WITH HEAD START FAMILIES: A BRIEF REPORT 总被引:5,自引:0,他引:5
Laura Johnson Rick Bruhn Jon Winek Jeff Krepps Kelly Wiley 《Journal of marital and family therapy》1999,25(2):169-176
Play therapy and filial therapy show promise as effective ways to provide direct services to Head Start, addressing the needs of the children, the families, and the Head Start teachers and staff. This paper examines the utility of play and filial therapies for the Head Start population, presents a systemic explanation for the benefit of filial therapy, and provides a case example for illustration. 相似文献
24.
We show that under reasonable conditions the nonparametric maximum likelihood estimate (NPMLE) of the distribution function from left-truncated and case 1 interval-censored data is inconsistent, in contrast to the consistency properties of the NPMLE from only left-truncated data or only interval-censored data. However, the conditional NPMLE is shown to be consistent. Numerical examples are provided to illustrate their finite sample properties. 相似文献
25.
Rick Petosa PhD 《Journal of American college health : J of ACH》2013,61(1):26-31
Abstract The authors applied the stage-of-change construct in the transtheoretical model to examine the distribution of Asian (n = 869), African American (n = 373), White (n = 1322), and Hispanic (n = 535) American undergraduate students across the 5 stages of change for exercise. Stage of change varied as a function of ethnicity. Higher percentages of minorities were in the precontemplation and contemplation stages. The likelihood of being in these stages was from 43% to 82% greater for minorities than for White students. Also examined were the congruency between stage of change and self-reported levels of physical activity. Half of the sedentary students and 15.6% of the active students were misclassified by the stage-of-change procedure. Misclassification rates were higher for minority women (27.8%) than for White women (17.8%) and for Asian students (24.6%) compared with all others (20.6%). The results of this study have implications for the design of physical activity interventions based on stage of change. 相似文献
26.
Rick Rodriguez 《Comparative American Studies》2013,11(1-2):31-42
ABSTRACTJose Marti examines the American Civil War and the period of Reconstruction through the lens of Cuba’s failed attempts at independence as a way of disenchanting modernizers and annexationists who, seeking rapprochement with the U.S., would compromise South American and, more specifically, Cuban sovereignty. More to the point, as much as Marti draws parallels between Cuba and the U.S. South vis-à-vis Spain and the U.S. North, respectively, his troubling affinity with the Confederacy and the postbellum South chiefly exposes the North’s ideological elision of its imperial project. 相似文献
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Wheeler SA Round DK Sarre R O'Neil M 《Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming》2008,24(1):1-12
Although there has been much speculation about the possible links between gambling and crime rates, relevant quantitative
evidence has been practically non-existent in Australia to date. This paper reports the results of research that utilised
a model designed to investigate the potential relationship between electronic gaming machine expenditures and property (income-generating)
crime rates reported to police in local areas in South Australia in 2002–2003. The research found that the higher the expenditures
on gaming machines in a particular local area per adult, the higher the income-generating crime rate in that area. No such
relationship was found between gaming machine expenditure and non-income-generating crime rates. However, further research
is required before any policy-relevant conclusions can be drawn. 相似文献
29.
Lilly M. Langer Rick S. Zimmerman Ralph McNeal 《Population research and policy review》1992,11(3):233-247
This study deals with intervening factors such as family composition, religiosity, and HIV/AIDS knowledge in understanding the association of race and ethnicity with HIV/AIDS-related attitudes and behaviors. Data represent Wave 1 of a five-month panel design involving 10th grade students in eight public high schools in Dade County (greater Miami) Florida. Significant differences in attitudes and behaviors were found among racial/ethnic groups. Specifically, Hispanics had more negative attitudes about condom use than blacks or whites. Whites had the most permissive, and blacks the least permissive, sexual attitudes. Hispanics felt least confident and blacks felt most confident about interpersonal sexual skills. Blacks were most likely to have had sexual intercourse, and whites least likely. Religiosity was found to be a significant intervening variable in the less permissive sexual attitudes of both blacks and Hispanics. The most significant implication of this study is that racial/ethnic differences in sexual behavior can be explained more fully by socio-environmental factors such as family structure or religiosity than by knowledge or attitudes. Thus, interventions directed toward minority populations should focus on the development of alternative social environments that would support more positive behaviors. More specifically, extended family, religious youth groups, and other community organizations should be brought into the HIV/AIDS risk-reduction arena. 相似文献
30.
The dynamic capability view (DCV) is one of the most vibrant approaches to strategic management. In this study, the extant literature published between 1994 and 2011 is analysed, using bibliometric methods in order to explore the scope of this approach and detect current research priorities. For this purpose, the method of bibliographic coupling is introduced in management research, which shifts the focus of analysis from past traditions to current trends. Several clusters of thematically related research are extracted from bibliographic networks, which represent interconnected yet distinct subfields of inquiry within the DCV. The core cluster of the current DCV, which visualizes this research field's nascent but fragile identity, focuses on learning and change capabilities and relates them to firm performance, thus merging aspects of organization theory and strategic management. In addition, several peripheral clusters of research are identified, which reflect a parallel process of differentiation in the overall field. Both trends, i.e. of integration and differentiation, attest to the emancipation of the DCV as a distinct approach to strategic management. However, the DCV still lacks consensual concepts that allow comparisons of empirical studies and advance the theoretical understanding of dynamic capabilities. In the light of the above, some implications of this analysis for further research are discussed. 相似文献