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81.
To deal with high placebo response in clinical trials for psychiatric and other diseases, different enrichment designs, such as the sequential parallel design, two‐way enriched design, and sequential enriched design, have been proposed and implemented recently. Depending on the historical trial information and the trial sponsors' resources, detailed design elements are needed for determining which design to adopt. To assist in making more suitable decisions, we perform evaluations for selecting required design elements in terms of power optimization and sample size planning. We also discuss the implementation of the interim analysis related to its applicability. 相似文献
82.
Bhaumik DK Roy A Lazar NA Kapur K Aryal S Sweeney JA Patterson D Gibbons RD 《Statistical Methodology》2009,6(2):133-146
Modern methods for imaging the human brain, such as functional magnetic resonance imaging (fMRI) present a range of challenging statistical problems. In this paper, we first develop a large sample based test for between group comparisons and use it to determine the necessary sample size in order to obtain a target power via simulation under various alternatives for a given pre-specified significance level. Both testing and sample size calculations are particularly critical for neuroscientists who use these new techniques, since each subject is expensive to image. 相似文献
83.
Rishideep Roy 《统计学通讯:理论与方法》2014,43(14):2859-2869
The lack of memory property is a characterizing property of the exponential distribution in the continuous domain. In the bivariate setup different generalizations of the same are available in terms of survival function. We extend this lack of memory property in terms of bivariate probability density function and examine its characterization properties. In this process the density version of the lack of memory property can be interlinked with conditionally specified exponential distribution, bivariate reciprocal coordinate subtangent of the density curve and a few other derived measures. 相似文献
84.
Friedman's test is a widely used rank-based alternative to the analysis of variance (ANOVA) F-test for identifying treatment differences in a randomized complete block design. Many texts provide incomplete or misleading information about when Friedman's test may be appropriately applied. We discuss the assumptions needed for the test and common misconceptions. We show via simulation that when the variance or skew of the treatment distributions differ, application of Friedman's test to detect differences in treatment location can result in Type I error probabilities larger than the nominal α, and even when α is unaffected, the power of the test can be less than expected. 相似文献
85.
Public relation’s search for a unifying theory may be fulfilled through application of Alasdair MacIntyre’s concept of a “practice,” a very specific and value-laden concept. This article explores what it would mean to be a public relations practice in MacIntyre’s concept of the term and argues that such an approach to public relations is of value for the field. 相似文献
86.
87.
Nilabja Guha Anindya Roy Leonid Kopylev John Fox Maria Spassova Paul White 《Risk analysis》2013,33(9):1608-1619
The article proposes and investigates the performance of two Bayesian nonparametric estimation procedures in the context of benchmark dose estimation in toxicological animal experiments. The methodology is illustrated using several existing animal dose‐response data sets and is compared with traditional parametric methods available in standard benchmark dose estimation software (BMDS), as well as with a published model‐averaging approach and a frequentist nonparametric approach. These comparisons together with simulation studies suggest that the nonparametric methods provide a lot of flexibility in terms of model fit and can be a very useful tool in benchmark dose estimation studies, especially when standard parametric models fail to fit to the data adequately. 相似文献
88.
Often, the response variables on sampling units are observed repeatedly over time. The sampling units may come from different populations, such as treatment groups. This setting is routinely modeled by a random coefficients growth curve model, and the techniques of general linear mixed models are applied to address the primary research aim. An alternative approach is to reduce each subject’s data to summary measures, such as within-subject averages or regression coefficients. One may then test for equality of means of the summary measures (or functions of them) among treatment groups. Here, we compare by simulation the performance characteristics of three approximate tests based on summary measures and one based on the full data, focusing mainly on accuracy of p-values. We find that performances of these procedures can be quite different for small samples in several different configurations of parameter values. The summary-measures approach performed at least as well as the full-data mixed models approach. 相似文献
89.
90.
Roy D. Yarbrough 《Journal of Social Work Education》2013,49(2):116-121
This paper presents and utilizes an operational philosophy of social work education in an attempt to identify effective and useful educational experiences. The effects of educational philosophy on curriculum content and emphasis, selection of learning experiences, and the determination of learning outcomes is discussed. The value and utility of an explicit philosophy in educational decision making is also stressed. 相似文献