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971.
In this paper the one-machine scheduling problem with the objective of minimizing the mean tardiness subject to maintaining a prescribed number of tardy jobs is analysed. An algorithm for solving this problem is presented. It is proved that the schedule generated by the proposed algorithm is indeed optimal.  相似文献   
972.
Capacity planning is a critical element of any successful production planning and control system. A method of rough-cut capacity planning is developed, based on the bill-of-resources approach, that can be used to plan for capacity required for firms in a remanufacturing including overhaul repair operations environment. The modified bill-of-resources approach developed takes into account two major stochastic elements inherent in this environment; probabilistic material replacement factors and probabilistic routing files. A detailed example from an actual repair overhaul operation is presented to illustrate the technique.  相似文献   
973.
The purpose of this paper is to present a critical assessment of GRAI Grids as a tool for improved manufacturing integration. GRAI Grids, a key component of the GRAI approach, form an integral part of the Strathclyde Integration Method SIM for manufacturing integration. The contribution of the paper is thus to provide a 'third party' view of the effectiveness of GRAI Grids as a modelling tool. The paper presents a brief overview of the GRAI approach, concentrating particularly on the Grids, and an overview of SIM, showing how GRAI Grids are used. The main section of the paper presents an assessment and critique of GRAI Grids. Several benefits and limitations of the Grid as used in SIM and some suggestions for extensions are presented. The paper concludes that the use of the GRAI Grid, within a methodology, provides a unique insight into the behaviour and design of manufacturing information systems and that those who criticize the technique perhaps do so from a lack of awareness of its concepts, principles and advantages.  相似文献   
974.
SmithKline Beecham (SBPI) is a major player in the Indian pharmaceutical industry. Though relatively small in terms of turnover, it has performed Pharmaceuticals (India) exceptionally well in terms ofprofitability and growth rate. The firm has substantial cash reserves. However, the firm operates in 'mass production' mode at present, with the established finished goods inventory norms being in the range of 1 to 1.5 months. Competitive pressure on the firm is now forcing it to move towards world class manufacturing and the application of concepts from MRP II, JIT and OPT is under consideration. This paper describes the considerations that went into the justification, design and implementation of an integrated production planning and control system in this situaion.  相似文献   
975.
Today's manufacturing enterprises face tremendous competitive pressures. Global competition, together with market demands for customized products delivered just in time, place tremendous pressures on manufacturers. The emerging global economy is rapidly replacing local markets. The emergence of open markets, reductions in trade barriers, and improvements in transportation and communications links have led to a situation where local competition and markets operate in the context of global standards. This open infrastructure allows manufacturers to respond to these challenges by working more closely with their suppliers and customers, and by building extended enterprises across the whole value chain. Such extended enterprises present great challenges in terms of redesigning business processes to create a competitive advantage from the linkages they include. This paper describes the manufacturing philosophies currently in vogue. Any manufacturing or related business will need to use them, albeit tailored to its own circumstances, in one form or the other, to ensure its prosperity.  相似文献   
976.
A two-phase approach is used to examine the impact of job scheduling rules and tool selection policies for a dynamic job shop system in a tool-shared, flexible manufacturing environment. The first phase develops a generalized simulation model and analyses 'simple' job scheduling rules and tool selection policies under various operating scenarios. The results from this investigation are then used to develop and analyse various bi-criteria rules in the second phase of this study. The results show that the scheduling rules have the most significant impact on system performance, particularly at high shop load levels. Tool selection policies affect some of the performance measures, most notably, proportion of tardy jobs, to a lesser degree. Higher machine utilizations can be obtained at higher tool duplication levels but at the expense of increased tooling costs and lower tool utilization. The results also show that using different processing time distributions may have a significant impact on shop performance.  相似文献   
977.
It has been suggested that the motivation to spend effort is decreased in burnout patients, resulting in reduced cognitive performance. A question that remains is whether this decreased motivation can be reversed by motivational interventions. We investigated this by examining the effect of a motivational intervention on cognitive performance. We presented 40 burnout patients in The Netherlands and 40 matched healthy controls with a complex attention task. As expected, in a first block of trials the performance of the burnout patients was poorer than that of healthy controls. Subsequently, we provided the participants with fake positive feedback about their performance and announced that we would financially reward those who performed best in a subsequent block of trials. Contrary to the healthy controls, the burnout patients did not improve their performance and experienced more aversion to spend effort. The study demonstrated that impaired cognitive performance in burnout patients could not be reversed by motivational interventions, which is in line with contemporary theories on burnout that state that physiological changes in burnout may underlie a relatively long-term decrease in motivation. The implication of these results is that in practice employers and therapists might need to accept that there could be a reduction in cognitive performance in employees with burnout.  相似文献   
978.
Major natural disasters in recent years have had high human and economic costs, and triggered record high postdisaster relief from governments and international donors. Given the current economic situation worldwide, selecting the most effective disaster risk reduction (DRR) measures is critical. This is especially the case for low‐ and middle‐income countries, which have suffered disproportionally more economic and human losses from disasters. This article discusses a methodology that makes use of advanced probabilistic catastrophe models to estimate benefits of DRR measures. We apply such newly developed models to generate estimates for hurricane risk on residential structures on the island of St. Lucia, and earthquake risk on residential structures in Istanbul, Turkey, as two illustrative case studies. The costs and economic benefits for selected risk reduction measures are estimated taking account of hazard, exposure, and vulnerability. We conclude by emphasizing the advantages and challenges of catastrophe model‐based cost‐benefit analyses for DRR in developing countries.  相似文献   
979.
Listeria monocytogenes is a leading cause of hospitalization, fetal loss, and death due to foodborne illnesses in the United States. A quantitative assessment of the relative risk of listeriosis associated with the consumption of 23 selected categories of ready‐to‐eat foods, published by the U.S. Department of Health and Human Services and the U.S. Department of Agriculture in 2003, has been instrumental in identifying the food products and practices that pose the greatest listeriosis risk and has guided the evaluation of potential intervention strategies. Dose‐response models, which quantify the relationship between an exposure dose and the probability of adverse health outcomes, were essential components of the risk assessment. However, because of data gaps and limitations in the available data and modeling approaches, considerable uncertainty existed. Since publication of the risk assessment, new data have become available for modeling L. monocytogenes dose‐response. At the same time, recent advances in the understanding of L. monocytogenes pathophysiology and strain diversity have warranted a critical reevaluation of the published dose‐response models. To discuss strategies for modeling L. monocytogenes dose‐response, the Interagency Risk Assessment Consortium (IRAC) and the Joint Institute for Food Safety and Applied Nutrition (JIFSAN) held a scientific workshop in 2011 (details available at http://foodrisk.org/irac/events/ ). The main findings of the workshop and the most current and relevant data identified during the workshop are summarized and presented in the context of L. monocytogenes dose‐response. This article also discusses new insights on dose‐response modeling for L. monocytogenes and research opportunities to meet future needs.  相似文献   
980.
In a recently published note in this journal the need for independent control of the production rate (R) and production time (L) was established in order to adapt the economic production quantity (EPQ) model in JIT settings. In this comment we aim to improve the relevance of EPQ in a JIT environment. We focus on two issues, namely, modelling the production rate as a decision variable and also deriving an expession for the optimal number of batches (n* ) for the raw materials and/or subcomponents needed.  相似文献   
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