排序方式: 共有55条查询结果,搜索用时 15 毫秒
21.
Tetsuhisa Miwa A. J. Hayter Satoshi Kuriki 《Journal of the Royal Statistical Society. Series B, Statistical methodology》2003,65(1):223-234
Summary. The evaluation of the cumulative distribution function of a multivariate normal distribution is considered. The multivariate normal distribution can have any positive definite correlation matrix and any mean vector. The approach taken has two stages. In the first stage, it is shown how non-centred orthoscheme probabilities can be evaluated by using a recursive integration method. In the second stage, some ideas of Schläfli and Abrahamson are extended to show that any non-centred orthant probability can be expressed as differences between at most ( m −1)! non-centred orthoscheme probabilities. This approach allows an accurate evaluation of many multivariate normal probabilities which have important applications in statistical practice. 相似文献
22.
Bayesian adaptive patient enrollment restriction to identify a sensitive subpopulation using a continuous biomarker in a randomized phase 2 trial 下载免费PDF全文
With the development of molecular targeted drugs, predictive biomarkers have played an increasingly important role in identifying patients who are likely to receive clinically meaningful benefits from experimental drugs (i.e., sensitive subpopulation) even in early clinical trials. For continuous biomarkers, such as mRNA levels, it is challenging to determine cutoff value for the sensitive subpopulation, and widely accepted study designs and statistical approaches are not currently available. In this paper, we propose the Bayesian adaptive patient enrollment restriction (BAPER) approach to identify the sensitive subpopulation while restricting enrollment of patients from the insensitive subpopulation based on the results of interim analyses, in a randomized phase 2 trial with time‐to‐endpoint outcome and a single biomarker. Applying a four‐parameter change‐point model to the relationship between the biomarker and hazard ratio, we calculate the posterior distribution of the cutoff value that exhibits the target hazard ratio and use it for the restriction of the enrollment and the identification of the sensitive subpopulation. We also consider interim monitoring rules for termination because of futility or efficacy. Extensive simulations demonstrated that our proposed approach reduced the number of enrolled patients from the insensitive subpopulation, relative to an approach with no enrollment restriction, without reducing the likelihood of a correct decision for next trial (no‐go, go with entire population, or go with sensitive subpopulation) or correct identification of the sensitive subpopulation. Additionally, the four‐parameter change‐point model had a better performance over a wide range of simulation scenarios than a commonly used dichotomization approach. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
23.
We investigate the properties of Baker's (2008) bivariate distributions with fixed marginals and their multivariate extensions. The properties include the weak convergence to the Fréchet–Hoeffding upper bound, the product-moment convergence, as well as the dependence structures TP2 (totally positive of order 2), or MTP2 (multivariate TP2). In proving the weak convergence, a generalized local limit theorem for binomial distribution is provided. 相似文献
24.
Satoshi Hattori 《统计学通讯:理论与方法》2013,42(4):542-559
Counting process techniques have been successfully introduced to semiparametric inference of repeated measurements. Cheng and Wei (2000) proposed a simple inference procedure for the semiparametric proportional rate model, which reduces to relative risk regression models for binary data. While the baseline mean functions are completely unspecified, it still requires several assumptions for valid inference. In this article, a goodness-of-fit test for it is proposed based on cumulative residuals. Theoretical justification is provided and an illustration with a dataset from a clinical trial is given. Results of simulation studies to evaluate finite sample performance are also provided. 相似文献
25.
In randomized clinical trials, a treatment effect on a time-to-event endpoint is often estimated by the Cox proportional hazards model. The maximum partial likelihood estimator does not make sense if the proportional hazard assumption is violated. Xu and O'Quigley (Biostatistics 1:423-439, 2000) proposed an estimating equation, which provides an interpretable estimator for the treatment effect under model misspecification. Namely it provides a consistent estimator for the log-hazard ratio among the treatment groups if the model is correctly specified, and it is interpreted as an average log-hazard ratio over time even if misspecified. However, the method requires the assumption that censoring is independent of treatment group, which is more restricted than that for the maximum partial likelihood estimator and is often violated in practice. In this paper, we propose an alternative estimating equation. Our method provides an estimator of the same property as that of Xu and O'Quigley under the usual assumption for the maximum partial likelihood estimation. We show that our estimator is consistent and asymptotically normal, and derive a consistent estimator of the asymptotic variance. If the proportional hazards assumption holds, the efficiency of the estimator can be improved by applying the covariate adjustment method based on the semiparametric theory proposed by Lu and Tsiatis (Biometrika 95:679-694, 2008). 相似文献
26.
This research examines the relationships between wealth, cooperation, and trust. Utilizing implications from the social capital literature and democratic theory, we found that trust directly affects patterns of socio-economic interactions, especially shopping. We also found that commuting was widespread and it created a rural sprawl deficit that affected trust. Specifically, the results indicated that trust of others in the community (generalized to a certain degree) tended to encourage people to shop more in town, thus contributing to the development of the community, even when controlling for commuting. Findings from this study suggest that further community level research will yield more specifics about how trust (and social capital) works to increase wealth in a community. 相似文献
27.
Satoshi Morita Peter F. Thall B. Nebiyou Bekele Paul Mathew 《Journal of the Royal Statistical Society. Series C, Applied statistics》2010,59(1):19-34
Summary. Advances in understanding the biological underpinnings of many cancers have led increasingly to the use of molecularly targeted anticancer therapies. Because the platelet-derived growth factor receptor (PDGFR) has been implicated in the progression of prostate cancer bone metastases, it is of great interest to examine possible relationships between PDGFR inhibition and therapeutic outcomes. We analyse the association between change in activated PDGFR (phosphorylated PDGFR) and progression-free survival time based on large within-patient samples of cell-specific phosphorylated PDGFR values taken before and after treatment from each of 88 prostate cancer patients. To utilize these paired samples as covariate data in a regression model for progression-free survival time, and be cause the phosphorylated PDGFR distributions are bimodal, we first employ a Bayesian hierarchical mixture model to obtain a deconvolution of the pretreatment and post-treatment within-patient phosphorylated PDGFR distributions. We evaluate fits of the mixture model and a non-mixture model that ignores the bimodality by using a supnorm metric to compare the empirical distribution of each phosphorylated PDGFR data set with the corresponding fitted distribution under each model. Our results show that first using the mixture model to account for the bimodality of the within-patient phosphorylated PDGFR distributions, and then using the posterior within-patient component mean changes in phosphorylated PDGFR so obtained as covariates in the regression model for progression-free survival time, provides an improved estimation. 相似文献
28.
This paper deals with sparse K2×J(J>2) tables. Projection-method Mantel–Haenszel (MH) estimators of the common odds ratios have been proposed for K2×J tables, which include Greenland's generalized MH estimator as a special case. The method projects log-transformed MH estimators for all K2×2 subtables, which were called naive MH estimators, onto a linear space spanned by log odds ratios. However, for sparse tables it is often the case that naive MH estimators are unable to be computed. In this paper we introduce alternative naive MH estimators using a graph that represents K2×J tables, and apply the projection to these alternative estimators. The idea leads to infinitely many reasonable estimators and we propose a method to choose the optimal one by solving a quadratic optimization problem induced by the graph, where some graph-theoretic arguments play important roles to simplify the optimization problem. An illustration is given using data from a case–control study. A simulation study is also conducted, which indicates that the MH estimator tends to have a smaller mean squared error than the MH estimator previously suggested and the conditional maximum likelihood estimator for sparse tables. 相似文献
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The Euler characteristic heuristic has been proposed as a method for approximating the upper tail probability of the maximum of a random field with smooth sample path. When the random field is Gaussian, this method is proved to be valid in the sense that the relative approximation error is exponentially smaller. However, very little is known about the validity of the method when the random field is non-Gaussian. In this paper, as a milestone to developing the general theory about the validity of the Euler characteristic heuristic, we examine the Euler characteristic heuristic for approximating the distribution of the largest eigenvalue of an orthogonally invariant non-Gaussian random matrix. In this particular example, if the probability density function of the random matrix converges to zero sufficiently fast at the boundary of its support, the approximation error of the Euler characteristic heuristic is proved to be small and the approximation is valid. Moreover, for several standard orthogonally invariant random matrices, the approximation formula for the distribution of the largest eigenvalue and its asymptotic error are obtained explicitly. Our formulas are practical enough for the purpose of numerical calculations. 相似文献