Evaluation of different statistical methods using SAS software: an in silico approach for analysis of real-time PCR data

Real-time polymerase chain reaction (PCR) is reliable quantitative technique in gene expression studies. The statistical analysis of real-time PCR data is quite crucial for results analysis and explanation. The statistical procedures of analyzing real-time PCR data try to determine the slope of regression line and calculate the reaction efficiency. Applications of mathematical functions have been used to calculate the target gene relative to the reference gene(s). Moreover, these statistical techniques compare C_t (threshold cycle) numbers between control and treatments group. There are many different procedures in SAS for real-time PCR data evaluation. In this study, the efficiency of calibrated model and delta delta C_t model have been statistically tested and explained. Several methods were tested to compare control with treatment means of C_t. The methods tested included t-test (parametric test), Wilcoxon test (non-parametric test) and multiple regression. Results showed that applied methods led to similar results and no significant difference was observed between results of gene expression measurement by the relative method.     

Managing White‐Collar Work: An Operations‐Oriented Survey

Although white‐collar work is of vast importance to the economy, the operations management (OM) literature has focused largely on traditional blue‐collar work. In an effort to stimulate more OM research into the design, control, and management of white‐collar work systems, this paper provides a systematic review of disparate streams of research relevant to understanding white‐collar work from an operations perspective. Our review classifies research according to its relevance to white‐collar work at individual, team, and organizational levels. By examining the literature in the context of this framework, we identify gaps in our understanding of white‐collar work that suggest promising research directions.     

An Integrated Methodology for Assessment and Selection of the Project Risk Response Actions

In a systematic process of project risk management, after risk assessment is implemented, the risk analysts encounter the phase of assessment and selection of the project risk response actions (RA). As indicated by many researchers, there are less systematic and well-developed solutions in the area of risk response assessment and selection. The present article introduces a methodology including a modeling approach with the objective of selecting a set of RA that minimizes the undesirable deviation from achieving the project scope. The developed objective function comprises the three key success criteria of a project, namely, time, quality, and cost. Our model integrates overall project management into the project risk response planning (P2RP). Furthermore, the proposed model stresses on an equivalent importance for both "risk" and "response." We believe that applying the proposed model helps the project risk analyst in most effective and efficient manner dealing with his or her complicated RA selection problems. The application of the proposed model was implemented in projects in the construction industry in which it showed tremendous time, cost, and quality improvements.     

Resist or Comply: The Power Dynamics of Organizational Routines during Mergers

The role of power and agency in the development of organizational routines is under‐theorized. In this paper, we draw on an in‐depth qualitative case study of a merger between two academic institutions, a college of art and a university, and examine the diverging responses of two organizational routines (admissions and budgeting) during the course of the merger to understand how power dynamics contribute to resistance/compliance of routines. Our findings suggest that the differences in routines’ responses to a merger initiative can be explained by applying Bourdieu's theory of practice and by employing the concepts of field and symbolic capital to unpack power relations in the context of organizational routines, and to disclose why some routine participants can exercise their agency while others cannot. We find that (a) the field within which a routine operates and (b) the actors’ symbolic capital and position‐taking during change implementation shape routines’ responses to organizational change initiatives.     

A Parameter-Tuned Genetic Algorithm for Economic-Statistical Design of Variable Sampling Interval X-Bar Control Charts for Non-Normal Correlated Samples

Among innovations and improvements that occurred in the past two decades on the techniques and tools used for statistical process control (SPC), adaptive control charts have shown to substantially improve the statistical and/or economical performances. Variable sampling intervals (VSI) control charts are one of the most applied types of the adaptive control charts and have shown to be faster than traditional Shewhart control charts in identifying small changes of concerned quality characteristics. While in the designing procedure of the VSI control charts the data or measurements are assumed independent normal observations, in real situations the validity of these assumptions is under question in many processes. This article develops an economic-statistical design of a VSI X-bar control chart under non-normality and correlation. Since the proposed design consists of a complex nonlinear cost model that cannot be solved using a classical optimization method, a genetic algorithm (GA) is employed to solve it. Moreover, to improve the performances, response surface methodology (RSM) is employed to calibrate GA parameters. The solution procedure, efficiency, and sensitivity analysis of the proposed design are demonstrated through a numerical illustration at the end.     

Optimal Production and Admission Policies in Make‐to‐Stock/Make‐to‐Order Manufacturing Systems

In this article, we study optimal production and admission control policies in manufacturing systems that produce two types of products: one type consists of identical items that are produced to stock, while the other has varying features and is produced to order. The model is motivated by applications from various industries, in particular, the automobile industry, where a part supplier receives orders from both an original equipment manufacturer and the aftermarket. The product for the original equipment manufacturer is produced to stock, it has higher priority, and its demands are fully accepted. The aftermarket product is produced to order, and its demands can be either accepted or rejected. We characterize the optimal production and admission policies with a partial‐linear structure, and using computational analysis, we provide insights into the benefits of the new policies. We also investigate the impact of production capacity, cost structure, and demand structure on system performance.     

Bivariate negative binomial regression model with excess zeros and right censoring: an application to Indonesian data

We propose a bivariate hurdle negative binomial (BHNB) regression model with right censoring to model correlated bivariate count data with excess zeros and few extreme observations. The parameters of the BHNB regression model are obtained using maximum likelihood with conjugate gradient optimization. The proposed model is applied to actual survey data where the bivariate outcome is number of days missed from primary activities and number of days spent in bed due to illness during the 4-week period preceding the inquiry date. We compared the right censored BHNB model to the right censored bivariate negative binomial (BNB) model. A simulation study is conducted to discuss some properties of the BHNB model. Our proposed model demonstrated superior performance in goodness-of-fit of estimated frequencies.KEYWORDS: Zero inflation, over-dispersion, parameter estimation, model selection, right censoring     

In‐House Globalization: The Role of Globally Distributed Design and Product Architecture on Product Development Performance

Changes in the global economy and technological advances are stimulating increased geographic distribution of new product design and development efforts. For large organizations that design and develop complex products, this geographic distribution has added a new layer of complexity to product development operations. In this empirical study of a large auto manufacturer, we examine the operational performance implications of splitting the design of vehicle subsystems across multiple geographic locations. Our results indicate that global distribution diminishes the chance of completing tasks on time and degrades subsystem design quality. Finally, by examining the interplay between subsystem centrality and global distribution, we found that higher centrality in the product architecture amplifies the impact of global distribution on subsystem error rates.     

Two-Dimensional Warranty Cost Analysis for Second-Hand Products

In spite of the recent steady increase of the volume of the second-hand markets, often customers remain in doubt regarding the quality and durability of the second-hand products. Aiming to reduce and share this uncertainty, dealers offer warranty on their products. Offering warranty for second-hand products is a relatively new marketing strategy employed by dealers of used electronic equipment, furniture, automobiles, etc. Usually, for used products, the dealer's expected warranty cost is a function of product reliability, past age and usage, servicing strategy and conditions and terms of the warranty policy/contract. Sometimes the offered policy is limited by two parameters, typically the product age and usage after the sale. This type of policies is referred to as two-dimensional warranty policies. In this article, we develop statistical models for estimating the dealer's expected warranty cost for second-hand products sold with two-dimensional free repair/replacement warranty.     

Robust Estimation of Multi-response Surfaces Considering Correlation Structure

Response surfaces express the behavior of responses and can be used for both single and multi-response problems. A common approach to estimate a response surface using experimental results is the ordinary least squares (OLS) method. Since OLS is very sensitive to outliers, some robust approaches have been discussed in the literature. Although there are many methods available in the literature for multiple response optimizations, there are a few studies in model building especially robust models. Assuming correlated responses, in this paper, a robust coefficient estimation method is proposed for multi response problem based on M-estimators. In order to illustrate the performance of the proposed procedure, a contaminated experimental design using a numerical example available in the literature with some modifications is used. Both the classical multivariate least squares method and the proposed robust multivariate approach are used to estimate regression coefficients of multi-response surfaces based on this example. Moreover, a comparison of the proposed robust multi response surface (RMRS) approach with separate robust estimation of single response show that the proposed approach is more efficient.