Evaluation of Developmental Toxicity Data: A Discussion of Some Pertinent Factors and a Proposal

There is currently no well-accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. We initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. Such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. We proceed with a discussion of quantitative assessment of data and propose schemes for qualitative and quantitative developmental hazard assessments.     

Transfers in Kind: Why They Can Be Efficient and Nonpaternalistic – Comment

Bruce and Waldman make an important contribution regarding the Samaritan dilemma: the expectations of inheritance motivates the younger generation at the margin in the direction of welfare reducing behavior. However, these authors misinterpret the standard analysis on this matter as prediction instead of explanation; confuse governmental subsidies with private charitable giving, and uncritically examine Headstart and statist job training programs.     

Interprofessional education: a curriculum response to work with children and young people

This paper charts the development of undergraduate teaching material produced at the Open University in the United Kingdom. The School of Health and Social Welfare at the University has a long history of providing open and distance learning and multiprofessionally focused education and training opportunities. In this instance two courses, entitled ‘Working with Young People’ and ‘Working with Children and Families’, were created to meet the needs of a diverse student audience working across the public, voluntary and private social care, health and education sectors. The materials produced were underpinned by the desire of their academic authors to challenge long‐established assumptions about the nature of children and young people's lives. Crucially though, both course developments reflected a requirement to demonstrate how policies and services for children and young people might be significantly improved. Accordingly, the paper offers some useful indications as to how interprofessional working with children and young people could be fostered. Copyright © 2002 John Wiley & Sons, Ltd.     

Redistribution and compensation

In a model where individual incomes depend on the agents' characteristics, we provide characterizations of several redistribution mechanisms. These mechanisms are designed to eliminate the effects of characteristics that are to be considered irrelevant, while preserving the influence of relevant characteristics on individual incomes. The mechanisms discussed here are egalitarian-equivalent and conditionally egalitarian mechanisms, as well as averaging versions of these rules.An earlier version of the paper was presented at the 1994 Canadian Economic Theory Conference in Toronto. We thank John Roemer and a referee for their comments. Financial support through a grant from the Social Sciences and Humanities Research Council of Canada is gratefully acknowledged.     

Quality out-of-school care in Aotearoa/New Zealand

The out-of-school-care sector, a reasonably unregulated industry, has grown quickly despite minimal government investment in comparison to early childhood care. In 2006, the New Zealand government released a draft five-year strategic plan committing an extra $17.4 million per year to this area. This article examines the impact on providers, recipients, and quality standards with the influx of resources and attention.     

Sequential design approaches for bioequivalence studies with crossover designs

The planning of bioequivalence (BE) studies, as for any clinical trial, requires a priori specification of an effect size for the determination of power and an assumption about the variance. The specified effect size may be overly optimistic, leading to an underpowered study. The assumed variance can be either too small or too large, leading, respectively, to studies that are underpowered or overly large. There has been much work in the clinical trials field on various types of sequential designs that include sample size reestimation after the trial is started, but these have seen only little use in BE studies. The purpose of this work was to validate at least one such method for crossover design BE studies. Specifically, we considered sample size reestimation for a two-stage trial based on the variance estimated from the first stage. We identified two methods based on Pocock's method for group sequential trials that met our requirement for at most negligible increase in type I error rate.     

The Timing of Cohabitation and Engagement: Impact on First and Second Marriages

Using a multistate sample of marriages that took place in the 1990s, this study examined associations between premarital cohabitation history and marital quality in first (N = 437) and second marriages (N = 200) and marital instability in first marriages (intact N = 521, divorced N = 124). For first marriages, cohabiting with the spouse without first being engaged or married was associated with more negative interaction, higher self‐reported divorce proneness, and a greater probability of divorce compared to cohabiting after engagement or marriage (with patterns in the same direction for marital positivity). In contrast, there was a general risk associated with premarital cohabitation for second marriages on self‐reported indices of marital quality, with or without engagement when cohabitation began.