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11.
S. Rao Jammalamadaka Md. Aleemuddin Siddiqi Kaushik Ghosh 《Journal of applied statistics》2009,36(6):621-631
Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics. 相似文献
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Weighted distributions (univariate and bivariate) have received widespread attention over the last two decades because of their flexibility for analyzing skewed data. In this article, we propose an alternative method to construct a new family of bivariate and multivariate weighted distributions. For illustrative purposes, some examples of the proposed method are presented. Several structural properties of the bivariate weighted distributions including marginal distributions together with distributions of the minimum and maximum, evaluation of the reliability parameter, and verification of total positivity of order two are also presented. In addition, we provide some multivariate extensions of the proposed models. A real-life data set is used to show the applicability of these bivariate weighted distributions. 相似文献
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In this article we discuss various strategies for constructing bivariate Kumaraswamy distributions. As alternatives to the Nadarajah et al. (2011) bivariate model, four different models are introduced utilizing a conditional specification approach, a conditional survival function approach, and an Arnold–Ng bivariate beta distribution construction approach. Distributional properties for such bivariate distributions are investigated. Parameter estimation strategies for the models are discussed, as are the consequences of fitting two of the models to a particular data set involving the proportion of foggy days at two different airports in Colombia. 相似文献
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This paper examines the influence of religion on contraceptive method mix in the context of son preference among Bengali-speaking population of eastern India (i.e., West Bengal and Tripura) and Bangladesh. In spite of cultural similarity and parallel programmatic approach to family planning in these two distinct geopolitical spaces, differential use of contraception is evident. Using National Family Health Survey (2005–2006) and Bangladesh Demographic Health Survey (2007) and by employing sequential logit model, the paper finds evidence of latent son preference in adoption of modern contraception in Bengali-speaking Hindu and Muslim communities of eastern India. However, such practice is observed only among Hindus in Bangladesh. The paper further argues that although diffusion of the culture of son preference cuts across religious groups among Bengali-speaking community in eastern India, religious identity dominates over region in Bangladesh, encouraging minority Hindus to adopt a distinct pattern of contraceptive behavior with reference to sons. Such finding calls for further research in understanding the pros and cons of behavioral diffusion in majority–minority population mix in similar tradition and culture. 相似文献
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In this article, we consider Bayesian inference procedures to test for a unit root in Stochastic Volatility (SV) models. Unit-root tests for the persistence parameter of the SV models, based on the Bayes Factor (BF), have been recently introduced in the literature. In contrast, we propose a flexible class of priors that is non-informative over the entire support of the persistence parameter (including the non-stationarity region). In addition, we show that our model fitting procedure is computationally efficient (using the software WinBUGS). Finally, we show that our proposed test procedures have good frequentist properties in terms of achieving high statistical power, while maintaining low total error rates. We illustrate the above features of our method by extensive simulation studies, followed by an application to a real data set on exchange rates. 相似文献
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Usual derivation of BIC for the marginal likelihood of a model or hypothesis via Laplace approximation does not hold for a change-point which is a discrete parameter. We provide an analogue l BIC, which is a lower bound to the marginal likelihood of a model with change points and has an approximation error up to Op(1) like standard Schwartz BIC. Several applications are provided covering simulated r.v.'s and real financial figures on short-term interest rate. 相似文献
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One of the standard problems in statistics consists of determining the relationship between a response variable and a single predictor variable through a regression function. Background scientific knowledge is often available that suggests that the regression function should have a certain shape (e.g. monotonically increasing or concave) but not necessarily a specific parametric form. Bernstein polynomials have been used to impose certain shape restrictions on regression functions. The Bernstein polynomials are known to provide a smooth estimate over equidistant knots. Bernstein polynomials are used in this paper due to their ease of implementation, continuous differentiability, and theoretical properties. In this work, we demonstrate a connection between the monotonic regression problem and the variable selection problem in the linear model. We develop a Bayesian procedure for fitting the monotonic regression model by adapting currently available variable selection procedures. We demonstrate the effectiveness of our method through simulations and the analysis of real data. 相似文献