Assessing the Concept of the ‘Insecure‐Other’ Category in the Cassidy–Marvin Scheme: Changes Between 4 and 6 Years in the English and Romanian Adoptee Study

We set out to explore the meaning of the attachment categories in the Cassidy/Marvin strange situation procedure, as employed in the home, using data from a longitudinal study of children adopted into UK families up to the age of 42 months from Romanian institutions, and of adopted children without the experience of institutional care––both groups being assessed at 4 and 6 years of age. Inter‐rater reliability was found to be good. Security (meaning the use of the parent as a secure base and no negative behavior on reunion) was the modal categorical rating in both the institution‐reared and comparison groups, but the category of anomalous non‐normative behavior (meaning a lack of any ordered attachment behavior as covered by the standard ratings), previously labeled ‘insecure‐other’, was more common in the institution‐reared children. Because this was unassociated with the usual manifestations of insecurity (such as avoidance or resistance) and because it was largely evident in interactions with the stranger, it is concluded that the adjective ‘insecure’ was not appropriate. Although this ‘insecure‐other’ category was associated with disinhibited attachment as reported by parents (meaning a lack of differentiation among adults, a willingness to go off with strangers and a lack of checking back with parents in anxiety‐provoking situations), it did not prove to be a good index of disinhibited attachment because changes over time in the ‘insecure‐other’ category were not associated with changes in the rate of disinhibited attachment. Also, whereas the rate of ‘insecure‐other’ fell markedly in the institution‐reared group between 4 and 6 years of age, it rose in the comparison group, raising queries over its meaning.     

Multistage sampling for latent variable models

I consider the design of multistage sampling schemes for epidemiologic studies involving latent variable models, with surrogate measurements of the latent variables on a subset of subjects. Such models arise in various situations: when detailed exposure measurements are combined with variables that can be used to assign exposures to unmeasured subjects; when biomarkers are obtained to assess an unobserved pathophysiologic process; or when additional information is to be obtained on confounding or modifying variables. In such situations, it may be possible to stratify the subsample on data available for all subjects in the main study, such as outcomes, exposure predictors, or geographic locations. Three circumstances where analytic calculations of the optimal design are possible are considered: (i) when all variables are binary; (ii) when all are normally distributed; and (iii) when the latent variable and its measurement are normally distributed, but the outcome is binary. In each of these cases, it is often possible to considerably improve the cost efficiency of the design by appropriate selection of the sampling fractions. More complex situations arise when the data are spatially distributed: the spatial correlation can be exploited to improve exposure assignment for unmeasured locations using available measurements on neighboring locations; some approaches for informative selection of the measurement sample using location and/or exposure predictor data are considered.     

Considerations on group-wise identical designs for linear mixed models

We consider a general class of mixed models, where the individual parameter vector is composed of a linear function of the population parameter vector plus an individual random effects vector. The linear function can vary for the different individuals. We show that the search for optimal designs for the estimation of the population parameter vector can be restricted to the class of group-wise identical designs, i.e., for each of the groups defined by the different linear functions only one individual elementary design has to be optimized. A way to apply the result to non-linear mixed models is described.     

Assessing Effects on Long-term Survival after Early Termination of Randomized Trials

In this paper we present an approach to using historical control data to augment information from a randomized controlled clinical trial, when it is not possible to continue the control regimen to obtain the most reliable and valid assessment of long term treatment effects. Using an adjustment procedure to the historical control data, we investigate a method of estimating the long term survival function for the clinical trial control group and for evaluating the long term treatment effect. The suggested method is simple to interpret, and particularly motivated in clinical trial settings when ethical considerations preclude the long term follow-up of placebo controls. A simulation study reveals that the bias in parameter estimates that arises in the setting of group sequential monitoring will be attenuated when long term historical control information is used in the proposed manner. Data from the first and second National Wilms' Tumor studies are used to illustrate the method.     

Expressing Estimators of Expected Quality Adjusted Survival as Functions of Nelson-Aalen Estimators

Quality adjusted survival has been increasingly advocated in clinical trials to be assessed as a synthesis of survival and quality of life. We investigate nonparametric estimation of its expectation for a general multistate process with incomplete follow-up data. Upon establishing a representation of expected quality adjusted survival through marginal distributions of a set of defined events, we propose two estimators for expected quality adjusted survival. Expressed as functions of Nelson-Aalen estimators, the two estimators are strongly consistent and asymptotically normal. We derive their asymptotic variances and propose sample-based variance estimates, along with evaluation of asymptotic relative efficiency. Monte Carlo studies show that these estimation procedures perform well for practical sample sizes. We illustrate the methods using data from a national, multicenter AIDS clinical trial.     

Modelling change in cognitive understanding with finite mixtures

Psychological theories often posit the existence of several different states. Individuals are viewed as belonging to one of the states at a given age, but with development pass to another state. A main problem in evaluating such theories is representing the transition from one state to another over age. A stochastic transition framework is proposed which should be useful in many different settings. The model is illustrated with data from a cognitive development task.     

Adaptive Estimation Using Weighted Least Squares

This paper proposes an adaptive estimator that is more precise than the ordinary least squares estimator if the distribution of random errors is skewed or has long tails. The adaptive estimates are computed using a weighted least squares approach with weights based on the lengths of the tails of the distribution of residuals. Smaller weights are assigned to those observations that have residuals in the tails of long-tailed distributions and larger weights are assigned to observations having residuals in the tails of short-tailed distributions. Monte Carlo methods are used to compare the performance of the proposed estimator and the performance of the ordinary least squares estimator. The estimates that were studied in this simulation include the difference between the means of two populations, the mean of a symmetric distribution, and the slope of a regression line. The adaptive estimators are shown to have lower mean squared errors than those for the ordinary least squares estimators for short-tailed, long-tailed, and skewed distributions, provided the sample size is at least 20. The ordinary least squares estimator has slightly lower mean squared error for normally distributed errors. The adaptive estimator is recommended for general use for studies having sample sizes of at least 20 observations unless the random errors are known to be normally distributed.     

Using adaptive weighted least squares to reduce the lengths of confidence intervals

The author proposes an adaptive method which produces confidence intervals that are often narrower than those obtained by the traditional procedures. The proposed methods use both a weighted least squares approach to reduce the length of the confidence interval and a permutation technique to insure that its coverage probability is near the nominal level. The author reports simulations comparing the adaptive intervals to the traditional ones for the difference between two population means, for the slope in a simple linear regression, and for the slope in a multiple linear regression having two correlated exogenous variables. He is led to recommend adaptive intervals for sample sizes superior to 40 when the error distribution is not known to be Gaussian.     

A course in constructing effective displays of data for pharmaceutical research personnel

Interpreting data and communicating effectively through graphs and tables are requisite skills for statisticians and non‐statisticians in the pharmaceutical industry. However, the quality of visual displays of data in the medical and pharmaceutical literature and at scientific conferences is severely lacking. We describe an interactive, workshop‐driven, 2‐day short course that we constructed for pharmaceutical research personnel to learn these skills. The examples in the course and the workshop datasets source from our professional experiences, the scientific literature, and the mass media. During the course, the participants are exposed to and gain hands‐on experience with the principles of visual and graphical perception, design, and construction of both graphic and tabular displays of quantitative and qualitative information. After completing the course, with a critical eye, the participants are able to construct, revise, critique, and interpret graphic and tabular displays according to an extensive set of guidelines. Copyright © 2013 John Wiley & Sons, Ltd.