Data‐driven treatment selection for seamless phase II/III trials incorporating early‐outcome data

Seamless phase II/III clinical trials are conducted in two stages with treatment selection at the first stage. In the first stage, patients are randomized to a control or one of k > 1 experimental treatments. At the end of this stage, interim data are analysed, and a decision is made concerning which experimental treatment should continue to the second stage. If the primary endpoint is observable only after some period of follow‐up, at the interim analysis data may be available on some early outcome on a larger number of patients than those for whom the primary endpoint is available. These early endpoint data can thus be used for treatment selection. For two previously proposed approaches, the power has been shown to be greater for one or other method depending on the true treatment effects and correlations. We propose a new approach that builds on the previously proposed approaches and uses data available at the interim analysis to estimate these parameters and then, on the basis of these estimates, chooses the treatment selection method with the highest probability of correctly selecting the most effective treatment. This method is shown to perform well compared with the two previously described methods for a wide range of true parameter values. In most cases, the performance of the new method is either similar to or, in some cases, better than either of the two previously proposed methods. © 2014 The Authors. Pharmaceutical Statistics published by John Wiley & Sons Ltd.     

Re-examining female labor supply responses to the 1994 Australian pension reform

Many governments are aiming to extend working lives by raising the age at which people can claim retirement pensions. This makes it vital to understand how these policies affect retirement decisions. In this paper, I revisit the labor supply effects of a major Australian reform that increased women’s pension age from 60 to 65. Atalay and Barrett (2015) studied these effects using repeated household surveys and a differences-in-differences design in which male cohorts form the comparison group. They estimate that the reform increased female labor force participation by 12 percentage points. Using earlier data, I show that the parallel-trends assumption did not hold before the reform because of a strong female-specific trend in participation rates across the relevant cohorts. Accounting for this trend, the estimated effect on female participation falls by two-thirds and becomes statistically insignificant at conventional levels. This highlights the importance of carefully assessing and controlling for trends across cohorts when evaluating pension reforms, which are typically phased in across cohorts.

     

Children With Nonresident Parents: Living Arrangements,Visitation, and Child Support

One third of all children in the United States have a nonresident parent. On the basis of 13,085 children with a nonresident parent drawn from the 1997 National Survey of America's Families, this study examines nonresident mothers' and fathers' involvement (visitation and child support) with children who reside in different household types: single‐parent families, married and cohabiting stepfamilies, and families headed by grandparents, other relatives, or nonrelatives. The relationship between children's living arrangements and nonresident parent involvement is complex and depends on both the gender of the nonresident parent and the type of involvement. Because nonresident parent involvement is low regardless of household type, policies and programs designed to increase involvement should include children in a variety of family forms.     

Prevalence of childhood abuse in mothers taking part in a study of parenting their own children

This paper describes the incidence of maltreatment histories in a community sample of mothers of one‐year‐old infants in Northern Ireland. The occurrence of five subsets of childhood maltreatment is examined: emotional abuse, emotional neglect, physical abuse, physical neglect and sexual abuse. Of the 201 women who completed the Childhood Trauma Questionnaire, 70 mothers (35%) reported that they had experienced one or more types of maltreatment during childhood. Forty‐eight mothers (24%) gave a history of being emotionally abused, 43 (21%) of emotional neglect, 27 (13%) of physical abuse, 20 (10%) of sexual abuse and 19 (10%) of physical neglect. Physical abuse was the only type of maltreatment which showed an association with maternal socio‐economic status, with a higher incidence reported amongst Occupational Classes 4 and 5 (lower supervisory and technical occupations and semi‐routine and routine groups). More than half of those with a history of abuse experienced more than one type of maltreatment (42 mothers or 60% of those reporting maltreatment). Differences in rates of incidence to more recent studies on younger adults are discussed, as well as implications for prevention and intervention. Copyright © 2009 John Wiley & Sons, Ltd.     

Social Studies in the Modern Era: A Case Study of Effective Teachers' Use of Literacy and Technology

The purpose of this research project was to highlight the practices and philosophies of two effective—but different—social studies teachers who balance the demands of teaching in the modern era while honoring their own philosophies for teaching social studies. This project was ground in the theoretical framework provided by TPACK and used a case study methodology for its research design. While the pedagogical content knowledge of the participants was strong and technology was used abundantly for instructional purposes, this research raised questions regarding how teachers can most effectively use technology to enhance instruction by helping students conceptualize content knowledge and apply their learning in new ways.     

Government Documents Come of Age

In January 2007, the Oregon State Board of Education mandated a new Oregon diploma that strengthened high school graduation requirements with the aim of improving student readiness for college and career. Among the major changes was a requirement that students demonstrate proficiency in nine “essential skills” that included the expectation that students must “demonstrate global literacy.” This article examines the process through which Oregon developed and plans to implement the essential skills and compares its conceptualization of global literacy with alternate models of global education in other states and nations. The authors identify political and institutional factors influencing the shape and direction of those efforts and offer recommendations regarding a potential framework for defining, implementing, and assessing global literacy in Oregon high schools.     

Stress and social work lecturers: Dreaming spires,ivory towers or besieged in concrete blocks?

The focus of this article is upon the impact of environmental stress and demands on social work lecturers. Stress is experienced as an individual phenomenon by social work lecturers, but is considered within a structural and an institutional context. In particular, it is examined against the background of recent developments in higher education generally, such as the Higher Education Funding Council quality assessment visits and the research assessment exercise. In recent years, there have been significant alterations to the shape of social work education with the establishment of the DipSW, its modification and review, and the development of Post Qualifying Consortia. Classic features of stress have been imposed on social work lecturers particularly by their institutions and other organisations, leading to a lack of control, an imbalance of demands over resources, role overload and role conflict. These stressors impact negatively upon interpersonal relationships with colleagues and students. Some suggestions are made for improving the structural and especially the organisational coping resources available to social work lecturers in order to assist them to develop more effective responses to stress.     

Network centrality and social movement media coverage: A two-mode network analytic approach

This article examines the relationship between structural location (namely, degree centrality) and news media coverage. Our central hypothesis is that the network centrality of social movement actors is positively associated with the prevalence of actors being cited in the print news media. This paper uses two-mode data from a communication network of environmentalists in British Columbia, and examines the relationship between their structural location and the frequency by which they are cited in newsprint media with regard to particular frames (about forest conservation, environmental protest, and related issues). We asked a sample of social movement participants about their ties to a target list of relatively high profile actors (environmental activists). We turned the resulting network matrix into a bipartite graph that examined the relationships amongst the target actors vis a vis the respondents. Next we calculated point in-degree for the target actors. For the target actors we also have data from a representative sample of 957 print news articles about forestry and conservation of old growth forests in British Columbia. We compare the effects of network centrality of the target actor versus several attributes of the target actors (gender, level of radicalism, leadership status) on the amount of media coverage that each of the target actors receives. We find that network centrality is associated with media coverage controlling for actor attributes. We discuss theoretical implications of this research. Finally, we also discuss the methodological pros and cons of using a “target name roster” to construct two-mode data on social movement activists.