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Toshimitsu Hamasaki Tomoyuki Sugimoto Scott Evans Takashi Sozu 《Pharmaceutical statistics》2013,12(1):28-34
Clinical trials with event‐time outcomes as co‐primary contrasts are common in many areas such as infectious disease, oncology, and cardiovascular disease. We discuss methods for calculating the sample size for randomized superiority clinical trials with two correlated time‐to‐event outcomes as co‐primary contrasts when the time‐to‐event outcomes are exponentially distributed. The approach is simple and easily applied in practice. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献