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11.
The case fatality rate is an important indicator of the severity of a disease, and unbiased and accurate estimates of it during
an outbreak are important in the study of epidemic diseases, including severe acute respiratory syndrome (SARS). In this paper,
estimation methods are developed using a constant cure-death hazard ratio. A semiparametric model is presented, in which the
cure-death hazard ratio is a parameter of interest, and a profile likelihood-based technique is proposed for estimating the
case fatality rate. An extensive simulation was carried out to investigate the performance of this technique for small and
medium sample sizes, using both summary and individual data. The results show that the performance depends on the model validity
but is not heavily dependent on the sample size. The method was applied to summary SARS data obtained from Hong Kong and Singapore. 相似文献