Bayesian Experimental Design for Long-Term Longitudinal HIV Dynamic Studies

The study of HIV dynamics is one of the most important developments in recent AIDS research for understanding the pathogenesis of HIV-1 infection and antiviral treatment strategies. Currently a large number of AIDS clinical trials on HIV dynamics are in development worldwide. However, many design issues that arise from AIDS clinical trials have not been addressed. In this paper, we use a simulation-based approach to deal with design problems in Bayesian hierarchical nonlinear (mixed-effects) models. The underlying model characterizes the long-term viral dynamics with antiretroviral treatment where we directly incorporate drug susceptibility and exposure into a function of treatment efficacy. The Bayesian design method is investigated under the framework of hierarchical Bayesian (mixed-effects) models. We compare a finite number of feasible candidate designs numerically, which are currently used in AIDS clinical trials from different perspectives, and provide guidance on how a design might be chosen in practice.     

Sets of alternatives as Condorcet winners

We characterize sets of alternatives which are Condorcet winners according to preferences over sets of alternatives, in terms of properties defined on preferences over alternatives. We state our results under certain preference extension axioms which, at any preference profile over alternatives, give the list of admissible preference profiles over sets of alternatives. It turns out to be that requiring from a set to be a Condorcet winner at every admissible preference profile is too demanding, even when the set of admissible preference profiles is fairly narrow. However, weakening this requirement to being a Condorcet winner at some admissible preference profile opens the door to more permissive results and we characterize these sets by using various versions of an undomination condition. Although our main results are given for a world where any two sets – whether they are of the same cardinality or not – can be compared, the case for sets of equal cardinality is also considered. Received: 15 March 2001/Accepted: 31 May 2002 This paper was written while Barış Kaymak was a graduate student in Economics at Boğazi?i University. We thank ?ağatay Kayı and İpek ?zkal-Sanver who kindly agreed to be our initial listeners. The paper has been presented at the Economic Theory seminars of Bilkent, Ko? and Sabancı Universities as well as at the Fifth Conference of the Society for the Advancement of Economic Theory, July 2001, Ischia, Italy and at the 24^th Bosphorus Workshop on Economic Design, August 2001, Bodrum, Turkey. We thank Fuad Aleskerov, İzak Atiyas, ?zgür Kıbrıs, Semih Koray, Gilbert Laffond, Bezalel Peleg, Murat Sertel, Tayfun S?nmez, Utku ünver and all the participants. Remzi Sanver acknowledges partial financial support from İstanbul Bilgi University and the Turkish Academy of Sciences and thanks Haluk Sanver and Serem Ltd. for their continuous moral and financial support. Last but not the least, we thank Carmen Herrero and two anonymous referees. Of course we are the sole responsible for all possible errors.     

当代中国心理咨询与治疗本土化的途径

通过对国内心理咨询、治疗发展问题的分析认为,必须加速心理咨询与治疗本土化.心理咨询与治疗本土化的途径,首先是心理咨询和治疗者工作者自身的本土化.其次是加速心理测量的本土化,改革高校心理学专业课程设置、普及学校心理辅导、心理咨询,以及将传统心理咨询形式与现代心理咨询形式的结合.     

黑格尔与经典作家论哲学体系的逻辑展开

我国改革开放以来,马克思主义哲学的体系创新逐渐成为马克思主义哲学的研究重点之一,作者认为重温黑格尔、马克思、恩格斯和列宁关于构建科学的哲学体系的思想对于推动这个问题的研究是有重要意义的。在作者看来,他们构建科学的哲学体系的主要原则是逻辑与历史一致,其具体表现是哲学范畴、原理从抽象到具体的过程。文章重点论述了列宁构建科学的哲学体系的思想。     

Data skeletons: simultaneous estimation of multiple quantiles for massive streaming datasets with applications to density estimation

We consider the problem of density estimation when the data is in the form of a continuous stream with no fixed length. In this setting, implementations of the usual methods of density estimation such as kernel density estimation are problematic. We propose a method of density estimation for massive datasets that is based upon taking the derivative of a smooth curve that has been fit through a set of quantile estimates. To achieve this, a low-storage, single-pass, sequential method is proposed for simultaneous estimation of multiple quantiles for massive datasets that form the basis of this method of density estimation. For comparison, we also consider a sequential kernel density estimator. The proposed methods are shown through simulation study to perform well and to have several distinct advantages over existing methods.     

Constrained allocation problems with single-peaked preferences: An axiomatic analysis

We introduce a new class of problems that contains two existing classes: allocation problems with single-peaked preferences and bankruptcy problems. On this class, we analyze the implications of well-known properties such as Pareto optimality, strategy-proofness, resource-monotonicity, no-envy, equal treatment of equals, and two new properties we introduce, hierarchical no-envy and independence of nonbinding constraints. Unlike earlier literature, we consider rules that allow free-disposability. We present characterizations of a rule we introduce on this domain. We relate this rule to well-known rules on the aforementioned subdomains. Based on this relation, we present a characterization of a well-known bankruptcy rule called the constrained equal awards rule. Received: 22 June 2000/Accepted: 21 March 2002 This paper is based on the first chapter of my Ph.D. thesis submitted to the University of Rochester. I wish to thank my advisor, William Thomson, for helpful comments and suggestions.