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31.
Business establishment microdata typically are required to satisfy agency-specified edit rules, such as balance equations and linear inequalities. Inevitably some establishments' reported data violate the edit rules. Statistical agencies correct faulty values using a process known as edit-imputation. Business establishment data also must be heavily redacted before being shared with the public; indeed, confidentiality concerns lead many agencies not to share establishment microdata as unrestricted access files. When microdata must be heavily redacted, one approach is to create synthetic data, as done in the U.S. Longitudinal Business Database and the German IAB Establishment Panel. This article presents the first implementation of a fully integrated approach to edit-imputation and data synthesis. We illustrate the approach on data from the U.S. Census of Manufactures and present a variety of evaluations of the utility of the synthetic data. The paper also presents assessments of disclosure risks for several intruder attacks. We find that the synthetic data preserve important distributional features from the post-editing confidential microdata, and have low risks for the various attacks. 相似文献
32.
钱寅 《集美大学学报(哲学社会科学版)》2021,24(2):64-73
段、顾之争的根源是小学与经学之争.段玉裁的研究方法是根基于小学的考据方法,顾千里的研究方法则是具有传统经学特色的方法.段氏关注字句、片段在其他文献中所呈现的不同,然后施展考据功夫以求形成统一的文本;顾氏则更重视对经学家法的遵守,保持在不同家法传承下经文的差异性.从这一点看,顾千里的校勘和解读更符合经学本身的特征. 相似文献
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道德濡化具有代际制约性。在传统的和谐—控制型代际关系下,道德濡化模式为"前喻型",它使道德濡化得以较好实现。当代社会变迁中,代际关系趋于复杂,代际隔阂产生,前喻型道德濡化模式不再适应新的代际关系,道德濡化遭遇时代困境。当代道德濡化要想走出困境,需要建立和谐—平等型代际关系,建构互喻型道德濡化模式。 相似文献
35.
Wai Han Sun Heidi Yin Hai Miu Carlos King Ho Wong Joseph D. Tucker 《Journal of sex research》2018,55(1):31-44
Sexual health education for young people is crucial not only for development of norms but also for protection against vulnerabilities during this stage in life. Although several systematic reviews have examined the effectiveness of peer-led sex education, none have focused on the extent of peer participation. The purpose of this review was to evaluate peer-led sexual health education interventions in more developed countries (MDCs). Electronic and manual searches across five social science, education, and medical databases were conducted. Fifteen articles were selected in total. Most (10 of 15) studies gave low or no responsibility to peers. The majority of articles found improvements in sexual health knowledge (13 of 14) and attitudes (11 of 15) at postintervention stages. Two studies showed improved self-efficacy, and three showed behavioral changes. A preliminary synthesis of effectiveness and level of participation was done. Meta-analysis revealed a large effect on knowledge change (Hedges’ g = 0.84, 95% confidence interval [CI]: 0.43 to 1.25) and a medium effect on attitude change (Hedges’ g = 0.49, 95% CI: 0.19 to 0.80). Peer-led interventions could be a powerful tool. This review shows that this approach is effective in changing knowledge and attitudes but not behaviors. Further research and action are needed to understand optimal implementation. 相似文献
36.
Bayesian adaptive dose‐escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy
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Wai Yin Yeung Bruno Reigner Ulrich Beyer Cheikh Diack Daniel Sabanés bové Giuseppe Palermo Thomas Jaki 《Pharmaceutical statistics》2017,16(6):396-413
The main purpose of dose‐escalation trials is to identify the dose(s) that is/are safe and efficacious for further investigations in later studies. In this paper, we introduce dose‐escalation designs that incorporate both the dose‐limiting events and dose‐limiting toxicities (DLTs) and indicative responses of efficacy into the procedure. A flexible nonparametric model is used for modelling the continuous efficacy responses while a logistic model is used for the binary DLTs. Escalation decisions are based on the combination of the probabilities of DLTs and expected efficacy through a gain function. On the basis of this setup, we then introduce 2 types of Bayesian adaptive dose‐escalation strategies. The first type of procedures, called “single objective,” aims to identify and recommend a single dose, either the maximum tolerated dose, the highest dose that is considered as safe, or the optimal dose, a safe dose that gives optimum benefit risk. The second type, called “dual objective,” aims to jointly estimate both the maximum tolerated dose and the optimal dose accurately. The recommended doses obtained under these dose‐escalation procedures provide information about the safety and efficacy profile of the novel drug to facilitate later studies. We evaluate different strategies via simulations based on an example constructed from a real trial on patients with type 2 diabetes, and the use of stopping rules is assessed. We find that the nonparametric model estimates the efficacy responses well for different underlying true shapes. The dual‐objective designs give better results in terms of identifying the 2 real target doses compared to the single‐objective designs. 相似文献
37.
To enhance modeling flexibility, the authors propose a nonparametric hazard regression model, for which the ordinary and weighted least squares estimation and inference procedures are studied. The proposed model does not assume any parametric specifications on the covariate effects, which is suitable for exploring the nonlinear interactions between covariates, time and some exposure variable. The authors propose the local ordinary and weighted least squares estimators for the varying‐coefficient functions and establish the corresponding asymptotic normality properties. Simulation studies are conducted to empirically examine the finite‐sample performance of the new methods, and a real data example from a recent breast cancer study is used as an illustration. The Canadian Journal of Statistics 37: 659–674; 2009 © 2009 Statistical Society of Canada 相似文献
38.
《红楼梦》“儿”缀称名遵循社会语言学“权势”与“等同”两条原则.在权势不等的人中使用,只可能是单向的,体现了交际双方不平等的权势关系.在权势相等时,有无等同关系制约交际者是否使用“儿”缀称名,以显示亲密或礼貌.这体现出权势关系不同参数之间的竞争以及在等同原则支配下交际者使用“儿”缀称名的不对称性. 相似文献
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浅析中国土族人口分布格局及其社会发展 总被引:2,自引:0,他引:2
人口分布格局,既是人在空间分布上呈现出来的地理状态,又是许多附着于分布环境上的社会人文变量的外在表现,因此对其进行研究具有探索自然和认识社会的双重意义。本文就中国土族人口的分布格局进行探讨,从历史和现实两方面分析了形成这种分布的原因,并在此基础上探讨了与人口分布格局密切相关的人口城市化、人口流动、人口素质提高、区域经济发展等社会热点问题,以期为政府政策的制定提供可靠的依据。 相似文献