Benefit Analysis for Natural Hazards

The objective of this paper is to develop the ex ante perspective for benefit analysis with natural hazards. It defines an ex ante evaluation of the economic benefits that arise from policies designed to reduce either the risk of or the detrimental effects associated with a natural hazard. In the process the paper compares the ex ante and ex post perspectives and discusses the prospects for implementing the framework by measuring the valuation concepts that are developed.     

A Semi-parametric Bayesian Analysis of Survival Data Based on Lévy-driven Processes

In the presence of covariate information, the proportional hazards model is one of the most popular models. In this paper, in a Bayesian nonparametric framework, we use a Markov (Lévy-driven) process to model the baseline hazard rate. Previous Bayesian nonparametric models have been based on neutral to the right processes, which have a number of drawbacks, such as discreteness of the cumulative hazard function. We allow the covariates to be time dependent functions and develop a full posterior analysis via substitution sampling. A detailed illustration is presented.     

A Multiple Imputation Approach to the Analysis of Current Status Data with the Additive Hazards Model

This article discusses regression analysis of current status data, which occur in many fields including cross-sectional studies, demographical investigations, and tumorigenicity experiments (Keiding, 1991 Keiding , N. ( 1991 ). Age-specific incidence and prevalence: a statistical perspective (with discussion) . J. Roy. Statist. Soc. Ser. A 154 : 371 – 412 .[Crossref] , [Google Scholar]; Sun 2006 Sun , J. ( 2006 ). The Statistical Analysis of Interval-Censored Failure Time Data . New York : Springer-Verlag . [Google Scholar]). For the problem, we focus on the situation where the survival time of interest can be described by the additive hazards model and a multiple imputation approach is presented for inference. A major advantage of the approach is its simplicity and it can be easily implemented by using the existing software packages for right-censored failure time data. Extensive simulation studies are conducted and indicate that the approach performs well for practical situations and is comparable to the existing methods. The methodology is applied to a set of current status data arising from a tumorigenicity experiment and the model checking is discussed.     

A Generalized Time-Dependent Conditional Linear Model with Left-Truncated and Right-Censored Data

Consider the model φ(S(y | X)) = β(y) ^T X, where φ is a known link function, S(· | X) is the survival function of a response Y given a covariate X = (1, X, X ²,…, X ^p ), and β(y) is an unknown vector of time-dependent regression coefficients. The response Y is subject to left truncation and right censoring. We assume that given X, Y is independent of (C, T) where C and T are censoring and truncation variables with P(C ≥ T) = 1. In this article, with some modification of the assumptions in Lemmas 5 and 6 of Iglesias-Pérez and González-Manteiga (1999 Iglesias-Pérez , C. J. , González-Manteiga , W. G. ( 1999 ). Strong representation of a generalized product-limit estimator for truncated and censored data with some application . J. Nonparametric Statist. 10 : 213 – 244 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), we present an almost sure representation for the generalized product-limit estimator (GPL) of S(y | X). Based on the GPL and the approach of Teodorescu et al. (2010 Teodorescu , B. , Keilegom , I. V. , Cao , R. ( 2010 ). Generalized time-dependent conditional linear models under left truncation and right censoring . Ann. Instit. Statist. Math. 62 : 465 – 485 .[Crossref], [Web of Science ®] , [Google Scholar]), a least squares estimator of β(y) is obtained and a bootstrap procedure is proposed to choose the optimum bandwidth.     

Estimation Bias in Complete-Case Analysis in Crossover Studies with Missing Data

Crossover designs are used often in clinical trials. It is not uncommon that subjects discontinue before completing all treatment periods in a crossover study. Despite availability of statistical methodologies utilizing all available data and software for obtaining valid inferences under the assumption of missing at random (MAR), naïve approaches, such as the complete case (CC) analysis, which is only valid with a strong assumption of missing completely at random are still widely used in practice. In this article, we obtain the analytical form of the estimation bias of treatment effects with CC for linear mixed models. We use simulation studies to examine the inflation of Type I error and efficiency loss in the inferences with CC under MAR. Invalidity and inefficiency of two other commonly used approaches for defining analyzed data in the presence of missing data, including data from at least two periods in three period crossover and available cases for a specific comparison of interest, are also demonstrated through simulation studies.     

A proportional hazards model for the analysis of doubly censored competing risks data

ABSTRACT

Competing risks data are common in medical research in which lifetime of individuals can be classified in terms of causes of failure. In survival or reliability studies, it is common that the patients (objects) are subjected to both left censoring and right censoring, which is refereed as double censoring. The analysis of doubly censored competing risks data in presence of covariates is the objective of this study. We propose a proportional hazards model for the analysis of doubly censored competing risks data, using the hazard rate functions of Gray (1988 Gray, R.J. (1988). A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann. Statist. 16:1141–1154.[Crossref], [Web of Science ®] , [Google Scholar]), while focusing upon one major cause of failure. We derive estimators for regression parameter vector and cumulative baseline cause specific hazard rate function. Asymptotic properties of the estimators are discussed. A simulation study is conducted to assess the finite sample behavior of the proposed estimators. We illustrate the method using a real life doubly censored competing risks data.     

Empirical likelihood inference for a semiparametric hazards regression model

ABSTRACT

We investigated the empirical likelihood inference approach under a general class of semiparametric hazards regression models with survival data subject to right-censoring. An empirical likelihood ratio for the full 2p regression parameters involved in the model is obtained. We showed that it converged weakly to a random variable which could be written as a weighted sum of 2p independent chi-squared variables with one degree of freedom. Using this, we could construct a confidence region for parameters. We also suggested an adjusted version for the preceding statistic, whose limit followed a standard chi-squared distribution with 2p degrees of freedom.     

On Redundancy Allocation to Series and Parallel Systems of Two Components

Abstract

For two components and one standby redundancy, we develop a characterization on the hazard rate order and the reversed hazard rate order of the redundant system lifetime in the context of mutually independent components lifetimes. Also, the likelihood ratio order is derived on the lifetime of the series system with two components lifetimes and two matched active redundancies lifetimes both following the proportional hazard model.     

Tests of association between survival time and a continuous covariate

Proportional hazards model(Cox, 1972) is reviewed for the case of grouped data with one continuously measured covariate. This leads to a logit-rank procedure for tied data which is reduced to the test proposed by O’Brien(1978) and studied by O’Quigley and Prentice(1991) in the absence of ties. The proposed test is then applied to a special ranking method in order to study non-monotonic associations.     

LIKELIHOOD APPROXIMATIONS AND DISCRETE MODELS FOR TIED SURVIVAL DATA

ABSTRACT

Ties among event times are often recorded in survival studies. For example, in a two week laboratory study where event times are measured in days, ties are very likely to occur. The proportional hazards model might be used in this setting using an approximated partial likelihood function. This approximation works well when the number of ties is small. On the other hand, discrete regression models are suggested when the data are heavily tied. However, in many situations it is not clear which approach should be used in practice. In this work, empirical guidelines based on Monte Carlo simulations are provided. These recommendations are based on a measure of the amount of tied data present and the mean square error. An example illustrates the proposed criterion.