Four tests of fit for the beta-binomial distribution

Tests based on the Anderson–Darling statistic, a third moment statistic and the classical Pearson–Fisher X ² statistic, along with its third-order component, are considered. A small critical value and power study are given. Some examples illustrate important applications.     

Constructing identity with L2: Pronunciation and attitudes among Norwegian learners of English1

This study investigates L2 pronunciation and evaluation of American and British varieties of English among Norwegian adolescent learners. By integrating quantitative sociolinguistics and L2 acquisition, the article investigates stylistic practice in an L2 context. Results from an auditory analysis of four phonological variables and a matched‐guise test are interpreted with reference to speaker commentary. Learners’ self‐expressed accent aims correlate significantly with accent use, but American English is the dominant pronunciation. Results show that both L1 and L2 speakers of English varieties are socially evaluated by the learners; British English is considered the most prestigious model of pronunciation, while American English is associated with informality. These evaluations seem to motivate learners’ pronunciation choices. The data indicate blended use of the English varieties. Learners seem to exploit linguistic resources from English, and reshape and adapt the social meaning of the variables to a local construction of identity.     

Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men

Abstract

Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low total (≤11?nmol/L) or free testosterone (≤0.18?nmol/L) being carriers of the variant A-allele in ESR1 was associated with 7.3 and 15.9 times, respectively, increased odds ratio of being diagnosed with diabetes mellitus type 2 (p?=?0.025 and p?=?0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes.     

3-状态部分2-树网络可靠度的一个多项式时间算法

本文利用3-状态设备网络可靠度计算归约公式,结合Wald.J.A.-Colbourn C.J.[1]算法(简称为W-C算法2),给出了3-状态部分2-树网络可靠度的一个多项式时间算法.     

近三十年新疆高校少数民族汉语教学研究述评

文章对1979年以来发表在新疆主要刊物和区外核心刊物中的423篇高校少数民族汉语教学研究论文进行了统计分析。在30年的发展中其成绩主要表现在研究基础不断扩大、研究论题走向广泛与细化、研究方法有一定的改进。而存在的主要缺憾是研究内容不深入、研究方法单一,定量和定性研究重视不够等问题。目前新疆高校少数民族汉语教育虽然有较大发展,但在教学上过度依赖对外汉语教学,在研究层次上仍处于相对较低的水平。     

饱和粘土蠕变特性研究及参数确定

将两种弹 粘弹性模型（Burgers和H 2K模型）的一维蠕变方程，转换成三维状态下的应力 应变 时间关系，分别推导出常应力下两种模型的轴向应变随时间变化的方程。采用分级加载法进行室内长期单轴压缩蠕变试验，结合两种模型三维应力状态的轴向应变表达式，对试验结果进行拟合，得出相应模型的本构参数。试验结果表明：饱和粘土在新增荷载作用下2~3　d变形趋于稳定，Burgers模型和H 2K模型均能较好地模拟饱和粘土的衰减蠕变过程；而H 2K模型能更好地模拟土样在常应力作用下的蠕变特性。     

P2P技术带来的版权问题与对策研究

上个世纪末以来,以Napster为代表的P2P软件的迅速兴盛,在导致P2P技术迅猛发展并打破了传统的以服务器为中心的互联网格局的同时,在版权领域也引发了一场又一场侵权与反侵权的较量。我们需要在详细解读P2P技术的基础上,从与P2P技术有关的行为性质入手,对哪些属于不侵权、哪些是直接侵权、哪些是间接侵权,进行界定,对P2P技术带来的版权侵权问题和对策作出较为全面和详细的研究。     

高校干部“双肩挑”与管理职业化的理论思考

管理职业化是现代大工业生产方式和组织运作的基本要求,而在我国高校,却长期存在着不同于管理职业化模式的另外一种模式——“双肩挑”干部管理模式。“双肩挑”干部管理模式中存在的问题是由于“双肩挑”的兼职管理方法与管理职业化要求产生的冲突导致的,而我国高校内部管理权力配置中顺应学术权力提升要求又为“双肩挑”模式的存在提供了合理性支持,因此,对高校管理干部、尤其是教学科研单位管理干部的“双肩挑”模式应该在肯定的前提下予以改进。     

Reversed preservation of stochastic orders for random minima and maxima with applications

In this paper, reversed preservation properties of right spread order, total time on test order and increasing convex (concave) order when taking random minima and maxima are developed. In this context, reversed preservation properties of some ageing concepts are investigated under parallel (series) systems which are composed of a random number of i.i.d. components. Some applications in reliability and economics are given.     

SSAO酶抑制剂对脂肪细胞内GLUT4转运作用的研究

SSAO酶在脂肪细胞中的含量较多,位于细胞膜上的SSAO酶的活性和其蛋白质的免疫反应性都是最大的。对于体内葡萄糖的运输和葡萄糖转运蛋白的转运,此酶起到了一定的促进作用,当它与底物在膜上反应后会引起信号传导刺激细胞内葡萄糖转运蛋白(GLUT4)从内部囊泡转移到细胞表面程,从而促进葡萄糖的运输和细胞对葡萄糖的吸收。如果有SSAO酶抑制剂存在,如氨基脲,二溴乙胺等,这种对GLUT4转运的促进作用就会被削弱。本研究的目的在于建立一种新的定量方法—竞争ELISA法来测试脂肪细胞膜上GLUT4的含量,从而确定SSAO酶抑制剂对GLUT4转运的作用。实验结果说明当SSAO醇抑制剂和脂肪细胞预温育一段时间后,质膜上GLUT4的含量发生下降,钒盐使得这种下降的程度加大,证明GLUT4由细胞内囊泡向细胞质膜转运的易位过程受到了抑制。此种竞争性ELISA的测试方法优点在于只需要少量的细胞膜样品就可以确定GLUT4的含量,灵敏度较高。